Blog - INTERNET MÉDICA

Onco-Hematologia: Genética Médica (Hematological Malignancies: Medical Genetics)

Por Paulo Leite 17/07/2023

– Os cânceres do sangue, ou hematológicos, são caracterizados pela multiplicação descontrolada de células sanguíneas cancerosas, que interferem na função das células sanguíneas normais.

– Estimar os riscos hereditários do câncer no sangue é clinicamente importante, para poder discriminar entre os indivíduos da população com diferentes riscos de malignidade.

– Os cânceres de sangue representam cerca de 10% de todos os diagnósticos de câncer e são mais comuns em homens do que em mulheres. Mais de 100 cânceres de sangue já foram identificados. Esses cânceres são classificados como leucemias, linfomas ou mielomas, e podem progredir de forma rápida (aguda) ou lenta (crônica), dependendo do diagnóstico específico. Sabe-se, há algum tempo, que certos tipos de câncer de sangue podem ocorrer em famílias. De fato, pesquisadores já identificaram alguns genes associados à leucemia hereditária (pode ser transmitida de pai para filho), o primeiro dos quais, RUNX1, foi descoberto em 2008.

■ Genetic predisposition to hematologic maligancy in childhood and adolescence

Francesco Fabozzi, Angela Mastronuzzi

Mediterr J Hematol Infect Dis. 2023; 15(1): e2023032

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10171214/

■ Genetic disorder with predisposition to paediatric haematopoietic malignancies – A review

A Filipiuk, A Kozakiewicz, K Kos´mider, M Lejaman, J Zawitkowska

Cancers (Basel) 2022 Aug; 14(15): 3569

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329786/

■ Review of guideline for the identification and clinical care of patients with genetic predisposition for hematological malignancies

Brigitte Schlegelberger, Cristina Mecucci, Marcin Wlodarski

Fam Cancer. 2021; 20(4): 295–30

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484082/

■ Epidemiology of cancer-associated venous thromboembolism in patients with solid and hematologic neoplasm in the Veterans Affairs Health Care System

Kylee L. Martens, Ang Li, Jennifer La et al

JAMA Netw Open. 2023 Jun; 6(6): e2317945

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10261992/

■ A systematic review of decision aids in hematologic malignancies: What are currently available and whta are we missing?

Janice Zhao, Maya Abdallah, Chandrika Sanapala, et al

Oncologist. 2023 Feb; 28(2): 105–115

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907042/

■ Analysis of 153115 patients with hematological malignancies refines the spectrum of familial risk

A Sud, S Chattopadyyay, H Thomsen et al

Blood 2019, vol 134 (12): 960-969

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789511/

■ Diagnosis and classification of Hematologic malignancies on the basis of genetics

J Taylor, W Xiao, O Abdel-Wahab

Blood 2017, vol 130 (4)

https://ashpublications.org/blood/article/130/4/410/37114/Diagnosis-and-classification-of-hematologic

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■ Médico Responsável: Dr Paulo Fernando Leite

CRMMG: 7026

Belo Horizonte/MG/Brasil

Email: pfleite1873@gmail.com

Julho 2023

Amiodarona: Casos Clínicos (Amiodarone: Case Reports)

Por Paulo Leite 07/07/2023

■ The role of amiodarone in post-operative hypothyroidism patient with factitious thyrotoxicosis and atrial fibrillation: a case report

Dien Aulia, Deasy Ardiany

Int J Surg Case Rep. 2023 May; 106: 10825

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172904/

■ Amiodarone thyroxicosis: a case of pharmacy error obscured by amiodarone supression of symptomas of highly elevated thyroxine concentration

T A Manasra, S Q Shah, S R Raj, P T Pollak

CJC Open 2023, vol 5 (2) 173-176

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984889/

■ Amiodarone-induced type 2 thyrotoxicosis

Darryl Portelli, Simon Mifsud, Alexia Abela, Stephen Fava

BMJ Case Rep. 2021; 14(1): e238145

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798414/

■ A rare case of intravenous amiodarone toxicity

Ana Lopes dos Santos, Margarida Lagarto, Cláudio Gouveia

Cureus. 2022 Aug; 14(8): e27958.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9465810/

■ Diffuse alveolar hemorrhage and acute esosinophilic by bronchoalveolar lavagem

Satoshi Anai, Yuri Nakayama, Hiroki Gushiken, et al

J Cardiol Cases. 2023 Mar; 27(3): 93–9

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995651/

■ Amiodarone-induced multiple organ damage in na Alström syndrome patient with end-stage renal disease and hepatic cirrhosis

Takuto Torimitsu, Tadashi Yoshida, Satomi Nishi, Hiroshi Itoh, Mototsugu Oya

CEN Case Rep. 2022 Feb; 11(1): 11–16

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811015/

■ Amiodarone-induced man syndrome: a case report

Ali Hossein Samadi Takaldani, Mohammad Negaresh, et al

J Med Case Rep. 2023; 17: 248.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10250067/

■ Amiodarone vs dronedarone for atrial fibrillation: a retrospective cohort study

J M Brophy, L Nadeau

CJC Open, vol 5 (1): 8-14

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869347/

■ Amiodarone-induced neuromyopathy in a geriatric patient

Michael Mark Stanton, Leyla Samii, Gentson Leung, Paula Pearce

BMJ Case Rep. 2020; 13(11): e236620

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643464/

■ Amiodarone: Torsade de pointes: case report

Reactions Weekly 2022, vol 1902 (1): 31

Reactions Weekly. 2022; 1902(1): 31

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008679/

■ New-onset hallucination with amiodarone: a case report

Jessica Molinaro, Peter DeVries, Jennifer Ha, Jennifer M. Knight

Ann Gen Psychiatry. 2022; 21: 34

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400302/

■ Early amiodarone pneumonitis: a case report

Abbas Soleimani, Houshang Bavandpour Karvane, Masoud Mortezazadeh, et al

Clin Case Rep. 2022 Dec; 10(12): e6808

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794917/

■ Small-vessel vasculitis after ST-segment elevation myocardial infarction: clopidogrel or amiodarone?

Saskia Lehr, Frank Meiss, Dimitra Kiritsi, Leonidas Tsakiris

JACC Case Rep. 2022 Aug 3; 4(15): 967–971

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350893/

■ Multiple direct fetal amiodarone administration for supraventrciular tachycardia with hydrops fetalis|: a case report

Irvan Adenin, Rachmat Dediat Kapnosa Hasani

Eur Heart J Case Rep. 2023 Apr; 7(4): ytad128

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088357/

■ Amiodarona & Transtornos da Tireóide: Casos Clínicos (Amiodarone & Thyroid Disorders: Case Reports)

Arquivos Blog Internet Médica – outubro 2021

https://internetmedica.com.br/amiodarona-transtornos-da-tireoide-casos-clinicos-amiodarone-thyroid-disorders-clinical-cases/

■ Amiodarone-induced lung toxicity: a case initially not correctly framed

M U Scaramozzino, G Sapone, U R Plastina, M Nucara

Cureus 2023, vol 15 (3): e36818

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146449/