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¨A leptospirose é uma zoonose com mais de 250 sorotipos patogênicos, com grande distribuição mundial, constituindo-se em doença negligenciada, e com repercussões graves, o que a torna importante problema de saúde pública. As suas manifestações clínicas possuem amplo espectro, desde síndrome febril, autolimitada, até formas graves e potencialmente fatais, como a síndrome de Weil, em que predominam icterícia, disfunção renal e hemorragias. A forma ictérica da leptospirose, descrita como síndrome de Weil, ocorre em 5-10% dos casos e em curto intervalo de tempo, cerca de quatro a nove dias, evolui com hemorragias e disfunção renal potencialmente fatais, mesmo com recursos terapêuticos intensivos. A síndrome de Weil representa uma manifestação rara, de alta gravidade e evolução potencialmente fatal, com necessidade de reconhecimento e tratamento precoces, reforçando a importância da avaliação clínica e alta suspeição perante as dificuldades laboratoriais ainda vigentes no diagnóstico da leptospirose¨.

 

■ Leptospirose em fase aguda evoluindo com síndrome de Weil e seu frágil diagnóstico sorológico: relato de caso

I A Pereira, B B Sathler, L G F Lopes et al

Rev Med Minas Gerais 2019, vol 29: e-2020

http://www.rmmg.org/artigo/detalhes/2512

 

■ Pathology and pathogenesis of human leptospirosis: a commented review

De Brito, Thales, Silva, Ana Maria Gonçalves da and Abreu, Patrícia Antonia Estima

Rev. Inst. Med. trop. S. Paulo, 2018, vol.60

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652018005000400&lng=en&nrm=iso

 

■ A young man with acute febrile illness, jaundice, renal failure and hemorrhages

V M Santos, T C Martins, M F S Helbingen et al

Revista de Medicina e Saúde de Brasília 2017, vol 6 (3)

https://portalrevistas.ucb.br/index.php/rmsbr/article/view/8986/5487

■ Cuadro ictérico hemorrágico grave causado por Leptospira interrogans serovar Icterohaemorrhagiae

Rojas-Jaimes, Jesus, Parrales-Donayre, Rocio M and Quispe Anquise, Isabel

CES Med., Dic 2016, vol.30, no.2, p.244-250

http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-87052016000200014&lng=en&nrm=iso

 

■ Case report: Weil´s disease with multiple organ failure in a child living in dengue endemic area

Dewi Lokida, Arif Budiman, Udjiani Edi Pawitro et al

BMC Res Notes. 2016; 9: 407

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986206/

 

■ Complicated Weil disease

V M dos Santos

Balkan Med J 2016, vol 33 (4): 480-481

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001832/

 

■ Leptospirosis in Humans

D A Haake, P N Levett

Curr Top Microbiol Immunol 2015, vol 387: 65-97

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442676/

 

■ A systematic review of the mortality from untreated leptospirosis

A J Taylor, D H Paris, P N Newton

PLoS Neglect Tropical Diseases june 2015

https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0003866

 

■ Current immunological and molecular tools for leptospirosis: diagnostics, vaccine design, and biomarkers for predicting severity

S Rajapakse, C Rodrigo, S M handunnetti, S D Fernando

Annals of Clinical Microbiology and Antimicrobials 2015, vol 14: 2

https://ann-clinmicrob.biomedcentral.com/articles/10.1186/s12941-014-0060-2

 

■ . Factors associated with thrombocytopenia in severe leptospirosis (Weil’s disease).

Daher, Elizabeth F. et al

Clinics, Feb 2014, vol.69, no.2, p.106-110

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322014000200106&lng=en&nrm=iso

 

■ Atrial flutter complicating severe leptospirosis: a case report

Silva, Francisco Theogenes Macêdo et al.

Rev. Soc. Bras. Med. Trop., Apr 2013, vol.46, no.2, p.246-248

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000200246&lng=en&nrm=iso

 

■ Atrial flutter complicating severe leptospirosis: a case report

Silva, Francisco Theogenes Macêdo et al.

Rev. Soc. Bras. Med. Trop., Apr 2013, vol.46, no.2, p.246-248

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000200246&lng=en&nrm=iso

 

■ Different patterns in a cohort of patients with severe leptospirosis (Weil syndrome): effects of an educational programin an endemic area

Elizabeth F. Daher, Geraldo B. Silva, Júnior, Rafael S. A. Lima et al

Am J Trop Med Hyg. 2011 Sep 1; 85(3): 479–484

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163870/

 

■ Caracterización biológica de dos aislados de Leptospira spp procedentes de pacientes colombianos con síndrome de Weil.

G, Harold Durango et al

CES Med., Jul 2010, vol.24, no.2, p.112-113

http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-87052010000200016&lng=en&nrm=iso

 

■ Severe Weil´s syndrome complicated by hemolytic anemia

S Zschiedrich, K Fischer

International Journal of Infectious Disease 2010, vol 14 (2): e181-e182

https://www.ijidonline.com/article/S1201-9712(09)00190-8/fulltext

 

■ Intensive care of a Weil´s disease with multiorgan failure

T Togal, A Sener, N Yucel et al

J Clin Med Res 2010, vol 2 (3): 145-149

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104646/

 

■ Leptospirosis: Puesta al día

Zunino M, Enna and Pizarro P, Rolando

Rev. chil. infectol., Jun 2007, vol.24, no.3, p.220-226

https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-10182007000300008

 

■ Weil’s disease: an unusually fulminant presentation characterized by pulmonary hemorrhage and shock 

Spichler, A. et al.

Braz J Infect Dis, Aug 2005, vol.9, no.4, p.336-340

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000400011&lng=en&nrm=iso

 

■ Leptospirosis: Presentación de una infección fulminante y revisión de la literatura.

Abuauad A, M. Cecilia et al.

Rev. chil. infectol., Mar 2005, vol.22, no.1, p.93-97

https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-10182005000100012&lng=es&nrm=iso

 

■ Penicillin at the late stage of leptospirosis: a randomized controlled trial.

Costa, Everaldo et al.

Rev. Inst. Med. trop. S. Paulo, June 2003, vol.45, no.3, p.141-145

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652003000300005&lng=en&nrm=iso&tlng=en

 

■ Clinicopathological and immunohistochemical featuresof the severe pulmonary form of leptospirosis

Silva, João José Pereira da et al.

Rev. Soc. Bras. Med. Trop., Aug 2002, vol.35, no.4, p.395-399

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822002000400017&lng=en&nrm=iso

 

■  Dr Paulo Fernando Leite

Cardiologia/Prevenção Cardiovascular

Estratificação de Risco Cardiovascular

Novo endereço:

Consultório: Rua Padre Rolim 815/sala 815

Tel: 33245518 (Consulta Particular/Unimed)

 

– Centro Médico Unimed BH/Contagem/Pedro I

Belo Horizonte/MG/Brasil

CRMMG: 7026

Email: pfleite1873@gmail.com

■ A review of the Alcohol Use Disorders Identification Test (AUDIT), AUDIT-C, and USAUDIT for screening in the United States: past issues and future directions

J C Higgins-Biddle, T F Babor

Am J Drug Alcohol Abuse 2018, vol 44 (6): 578-586

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217805/

 

■ O padrão de consume de álcool é alterado após a cirurgia bariátrica? Uma revisão integrativa

Gregorio, Valeria Duarte et al

ABCD, arq. bras. cir. dig., 2018, vol.31, no.2

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202018000200509&lng=pt&nrm=iso&tlng=pt (portuguese)

 

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202018000200509&lng=pt&nrm=iso&tlng=en (english)

 

■ Medications for alcohol use disorder: an overview

Mohammed Akbar, Mark Egli, Young-Eun Cho et al

Pharmacol Ther. 2018 May; 185: 64–85

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898984/

 

■ Medications for alcohol use disorder

B T Winslow, M Onysko, M Hebert

Am Fam Physician 2016, vol 93 (6): 457-465

http://www.aafp.org/afp/2016/0315/p457.html

 

■ Nutritional status during inpatient alcohol detoxification

Marie-Astrid Gautron, F Questel, M Lejoyeux et al

Alcohol and Alcoholism 2018, vol 53 (1) 64–70,

https://academic.oup.com/alcalc/article/53/1/64/4608042

 

■ The effect of brief interventions for alcohol among people mental health conditions: a systematic review of randomized trials and narrative synthesis

S Boniface, I Malet-Lambert, R Coleman et al

Alcohol and Alcoholism 2018, vol 53 (5): 282-293

https://academic.oup.com/alcalc/article/53/3/282/4774988

 

■ Effectiveness of mass media campaigns to reduce alcohol consumption and harm: a systematic review

B Young, S Lewis, S V Katikireddi et a

Alcohol and Alcoholism 2018, vol 53 (3): 302-316

https://academic.oup.com/alcalc/article/53/3/302/4796878

 

■ Changing collective social norms in favours of reduced harmful use of alcohol: a review of reviews

P Anderson, E Jané-Llopis, O S M Hasan, J Rehm

Alcohol and Alcoholism 2018, vol 53 (3): 326-332

https://academic.oup.com/alcalc/article/53/3/326/4810743

 

■ Instruments for the Evaluation of Alcohol Use in Indigenous Communities – A Systematic Review

Souza, Ronaldo Santhiago Bonfim de et al.

Trends Psychol., Sept 2018, vol.26, no.3, p.1589-1603

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2358-18832018000301589&lng=pt&nrm=iso&tlng=en

 

■ Alcohol and the risk of pneumonia: a systematic review and meta-analysis

E Simou, J Britton, J Leonardi-Bee

BMJ Open 2018, vol 8 (8)

https://bmjopen.bmj.com/content/8/8/e022344

 

■ Executive functions, memory, and social cognitive deficits and recovery in chronic alcoholism: a critical review to inform future research

Anne-Pascale Le Berre, Rosemary Fama, Edith V. Sullivan

Alcohol Clin Exp Res. 2017 Aug; 41(8): 1432–1443

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531758/

 

■ Exercise as treatment for alcohol use disorders: systematic review and meta-analysis

M Hallgren, D Vancampfort, E S Giesen et al

British Journal of Sports Medicine 2017, vol 51 (4)

http://bjsm.bmj.com/content/51/14/1058

 

■ Association between alcohol sports sponsorship and consumption: a systematic review

K Brown

Alcohol and Alcoholism 2016, vol 51 (6): 747-755

https://academic.oup.com/alcalc/article/51/6/747/2374095/Association-Between-Alcohol-Sports-Sponsorship-and

 

■ Sex differences in the behavioral sequelae of chronic ethanol exposure

Nicholas J. Jury, Jeffrey F. DiBerto, Thomas L. Kash, Andrew Holmes

Alcohol. 2017 Feb; 58: 53–60.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253321/

 

■ Long-term alcohol use patterns and HIV disease severity

Brandon D.L. Marshall, Janet P. Tate, Kathleen A. McGinnis et al

AIDS. 2017 Jun 1; 31(9): 1313–1321

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596310/

 

■ Treatment of alcohol use disorder in patients with alcoholic liver disease

Lorenzo Leggio, Mary R. Lee

Am J Med. 2017 Feb; 130(2): 124–13

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5263063/

 

■ Reduced drinking in alcohol dependence treatment, what is the evidence

K Mann, H –J Aubin, K Witkiewitz

Eur Addict Res 2017, vol 23: 219-230

https://www.karger.com/Article/FullText/481348

 

■ Influence of stress associated with chronic alcohol exposure on drinking

Howard C. Becker

Neuropharmacology. 2017 Aug 1; 122: 115–126

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497303/

 

■ Drug therapy for alcohol dependence in primary care in the UK: A Clinical Practice Research Datalinnk study

A Thompson, D M Aschcroft, L Owens et al

PLoS ONE2017, vol 12 (3)

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0173272

 

■ Long-term alcohol consumption and breast, upper aero-digestive tract and colorectal cancer risk: a systematic risk review and meta-analysis

H Jayasekara, R J MacInnis, R Room, D R English

Alcohol and Alcoholism 2016, vol 51 (3): 315-330

https://academic.oup.com/alcalc/article/51/3/315/2888170/Long-Term-Alcohol-Consumption-and-Breast-Upper

 

■ Reductions in alcohol craving following naltrexone treatment for heavy drinking

A W Helstrom, F C Blow, V Saymaker et al

Alcohol and Alcoholism 2016, vol 51 (5): 562-566

https://academic.oup.com/alcalc/article/51/5/562/1740449/Reductions-in-Alcohol-Craving-Following-Naltrexone

 

■ Does industry-driven alcohol marketing influence adolescent drinking behavior? A systematic review

S Scott, C Muirhead, J Schucksmith et al

Alcohol and Alcoholism 2016, vol 51 (1): 84-94

https://academic.oup.com/alcalc/article/52/1/84/2614654/Does-Industry-Driven-Alcohol-Marketing-Influence

 

■ A meta-analysis of theory of mind in alcohol use disorders

R C Onuoha, D S Quintana, M Lyyers, A J Guastella

Alcohol and Alcoholism 2016, vol 51 (4): 410-415

https://academic.oup.com/alcalc/article/51/4/410/1740697/A-Meta-analysis-of-Theory-of-Mind-in-Alcohol-Use

 

■ Consumo de álcool e condições de trabalho: uma revisão integrativa

G A S Costa, T H da Silva, A M Silveira

Rev Med Minas Gerais 2016, vol 26 (Supl 8): S118-S122

http://rmmg.org/artigo/detalhes/2134

 

■ Treatment of alcohol-induced psychotic disorder (alcoholic hallucinosis) – a systematic review

B Masood, P Lepping, D Romanov

Alcohol and Alcoholism 2016, vol 51 (5): 84-92

https://academic.oup.com/alcalc/article/53/3/259/4627701

 

■ Overview of the genetic of alcohol use disorder

E A Tawa, S D Hall, F W Lohff

Alcohol and Alcoholism 2016, vol 51 (5): 507-514

https://academic.oup.com/alcalc/article/51/5/507/2237006/Overview-of-the-Genetics-of-Alcohol-Use-Disorder

 

■ Measuring alcohol consumption in population surveys: a review of international guidelines and comparison with survey in England

M D Nugawela, T Langley, L Szatkowski, S Lewis

Alcohol and Alcoholism 2016, vol 51 (5): 84-92

https://academic.oup.com/alcalc/article/51/1/84/2888167/Measuring-Alcohol-Consumption-in-Population

 

■ Alcohol and atrial fibrillation

A Voskoboinik, S Prabhu, L Ling et al

JACC 2016, vol 68 (23)

http://www.onlinejacc.org/content/68/23/2567

 

■ The prevalence of metabolic syndrome in alcohol use disorders: a systematic review and meta-analysis

D Vancampfort, M Hallgren, J Mugisha et al

Alcohol and Alcoholism 2016, vol 51 (5): 515-521

https://academic.oup.com/alcalc/article/51/5/515/1740510/The-Prevalence-of-Metabolic-Syndrome-in-Alcohol

 

■ Alcohol use disorder in primary health care: What do we know and where do we go?

J Rehm, P Anderson, J Manthey et al

Alcohol and Alcoholism 2016, vol 51 (5): 412-427

https://academic.oup.com/alcalc/article/51/4/422/1739927/Alcohol-Use-Disorders-in-Primary-Health-Care-What

 

■ Biomarker-based approaches for assessing alcohol use disorders

Onni Niemelä

Int J Environ Res Public Health. 2016 Feb; 13(2): 16

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772186/

 

■ STREAM: Elucidanting how alcohol use disorders are managed in UK general practice today

F Coste, N Rahhai, P Wallace

Alcohol and Alcoholism 2016, vol 51 (4): 428-435

https://academic.oup.com/alcalc/article/51/4/428/1740834/STREAM-Elucidating-How-Alcohol-Use-Disorders-are

 

■ Alcohol marketing on twitter and Instagram: evidence of directly advertising to youth/adolescents

A E Barry, A M Bates, O Olusanya et al

Alcohol and Alcoholism 2016, vol 51 (4): 487-492

https://academic.oup.com/alcalc/article/51/4/487/1739960/Alcohol-Marketing-on-Twitter-and-Instagram

 

■ Fetal alcohol spectrum disorders: What pediatric providers need to know

A Nash, L Nash

Journal of Pediatric Health Care2017, vol 31(5): 594-606

https://www.jpedhc.org/article/S0891-5245(17)30072-X/fulltext

 

■ Alcohol use disorders in pregnancy

Jeffrey DeVido, Olivera Bogunovic, Roger D. Weiss

Harv Rev Psychiatry. 2015 Mar-Apr; 23(2): 112–121

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530607/

 

■  Dr Paulo Fernando Leite

Cardiologia/Prevenção Cardiovascular

Estratificação de Risco Cardiovascular

Novo endereço:

Consultório: Rua Padre Rolim 815/sala 815

Tel: 33245518 (Consulta Particular/Unimed)

 

– Centro Médico Unimed BH/Contagem/Pedro I

Belo Horizonte/MG/Brasil

CRMMG: 7026

Email: pfleite1873@gmail.com