Blog - INTERNET MÉDICA

Criptococose Online (Cryptococcosis)

Por Paulo Leite 13/08/2019

¨Criptococose (torulose, blastomicose européia, doença de Busse-Buschke) é micose de natureza sistêmica de porta de entrada inalatória causada por fungos do complexo Cryptococcus neoformans, atualmente com duas espécies: Cryptococcus neoformans e Cryptococcus gattii. Ambas causam meningoencefalite, de evolução grave e fatal, acompanhada ou não, de lesão pulmonar evidente, fungemia e focos secundários para pele, ossos, rins, supra-renal, entre outros. A mortalidade por criptococose é estimada em 10% nos países desenvolvidos chegando a 43% nos paises em desenvolvimento. Cryptococcus neoformans é cosmopolita, ocorre em diversos substratos orgânicos, freqüentemente associa-se a habitat de aves, excretas secas, ricas em fontes de nitrogênio, como uréia e creatinina. Condições favoráveis ao crescimento abundante desta levedura formam microfocos, notadamente em centros urbanos e relacionados a pombos. O ambiente domiciliar, particularmente na poeira doméstica, pode apresentar positividade (50% e 13%). Cryptococcus gattii tem sido isolado do ambiente principalmente em regiões tropicais e subtropicais, mas áreas de clima temperado e frio devem ser incluídas em sua distribuição. A criptococose ocorre como primeira manifestação oportunista em cerca de 4,4% dos casos de aids no Brasil. A criptococose é uma das micoses de mais fácil diagnóstico por apresentar marcado tropismo neurológico, abundância de elementos fúngicos no líquor e nas lesões, presença de cápsula característica, diagnóstico imunológico e coloração tecidual específica. Existem várias formas clínicas e tratamento da criptocosose: comprometimentos pulmonar, neurológico, ósseo, ocular, cutânea, renal, incluindo prostatite criptocóccica.¨

■ Drug development for cryptococcosis treatment: What can patents tell us?

Juliana Santos-Gandelman, Alice Machado-Silva

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■ Resistance and tolerance to Cryptococal infection: an intricate balance that controls the development of disease

M Shourian, S T Qureshi

Front Immunol jan 2019

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■ The diagnostic challenge of an infrequent spectrum of Cryptococcus infection

Case Reports in Radiology 2019, Article ID 5970648, 6 pages

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■ The status of cryptococcosis in Latin American

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■ The war on cryptococcosis: a review of the antifungal arsenal

A Mourad, J R Perfect

Mem Inst Oswaldo Cruz 2018, vol 113 (7): e17091

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851043/

■ Pulmonary cryptococcosis coexisting with adenocarcinoma: a case report and review of the literature

Liyang Li, Liang Zhuang, Jian Zhou, Changzhou Shao

J Med Case Rep. 2018; 12: 327

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■ Disseminated cryptococcosis in Crohn´s disease: a case report

Natthakit Chavapradit, Nasikarn Angkasekwinai

BMC Infect Dis. 2018; 18: 620

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■ Identification of Cryptococcus neoformans by MALDI-TOF mass spectrometry in blood culture

M R B Araújo, Elaine G M Santos, V Wolf, L F Seabra

Clinical & Biomedical Research 2018, vol 38 (2)

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■ Clinical features and radiological characteristics of pulmonary cryptococcosis

Hui Deng, Jie Zhang, Jia Li, Dongxu Wang, Lei Pan, Xinying Xue

J Int Med Res. 2018 Jul; 46(7): 2687–269

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■ Criptococose pulmonar simulando captação neoplásica na PET/CT

L P G de Farias, I G Padilha, M R L Lemos et al

Radiol Bras 2018, vol 51 (1)

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■ Cryptococcosis in Colombia: compilation and analysis of data from laboratory-based surveillance

Patricia Escandón, Jairo Lizarazo, Clara Inés Agudelo, Elizabeth Castañeda

J Fungi (Basel) 2018 Mar; 4(1): 32

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■ Case report: a fatal case of cryptococcosis in an immunocompetent patient due to Cryptococcus deuterogatti (AFLP6/VGII)

Bauer, C. Wickenhauser, A. Haak, N. Pazaitis, et al

JMM Case Rep. 2018 Oct; 5(10): e005168

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■ A call to arms: Quest for a cryptococcal vaccine

Marley C. Caballero Van Dyke, Floyd L. Wormley, Jr.

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■ Epidemiology of cryptococcosis and cryptococcal meningitis in a large retrospective cohort of patients after solid organ transplantation

Ige A. George, Carlos A. Q. Santos, Margaret A. Olsen,

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■ Cryptococcosis in late stage multiple myeloma: conside

S J Bowcock, K Yip, K Majumder et al

British Journal of Haematology march 2017: 687-687

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■ Tuberculosis/cryptococcosis co-infection in China between 1065 an 2016

Wenjie Fang, Lei Zhang, Jia Liu, David W Denning et al

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■ Refractory and/or relapsing cryptococcosis associated with acquired imune deficiency syndrome: clinical features, genotype and virulence factors of cryptococcus spp. Isolates

Erika Nascimento, Lucia H. Vitali, Ludmilla Tonani et al

Am J Trop Med Hyg. 2016 May 4; 94(5): 975–981

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■ Cryptococcosis in acquired immunodeficiency syndrome patients clinically confirmed and/or diagnosed at necropsy in a teaching hospital in Brazil

Rafael Garcia Torres, Renata Margarida Etchebehere, Sheila Jorge Adad et al

Am J Trop Med Hyg. 2016 Oct 5; 95(4): 781–785

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■ Disseminated cryptococcosis with skin lesions: report of a case series

Marina Zoéga Hayashida, Camila Arai Seque, Victor Pavan Pasin et al

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■ Immunity to Cryptococcus neoformans and C gatti during cryptococcosis

Josie F. Gibson, Simon A. Johnston

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■ Integrated therapy for HIV and cryptococcosis

Sirawat Srichatrapimuk, Somnuek Sungkanuparph

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E K Maziarz, J R Perfect

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■ Cryptococcus spp. em excretas de Columba livia (pombos domésticos) provenientes de um hospital universitário no Sul do Brasil.

Lima, Cristiane Tavares de, Klafke, Gabriel Baracy and Xavier, Melissa Orzechowski

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■ Fatal disseminated cryptococcosis with renal involvement in an HIV-infected patient

Daher, Elizabeth De Francesco et al

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■ Cryptococcosis in Colombian children and literature review

Jairo Lizarazo, Patricia Escandón, Clara Inés Agudelo, Elizabeth Castañed

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Sharon C.-A. Chen, Wieland Meyer, Tania C. Sorrell

Clin Microbiol Rev. 2014 Oct; 27(4): 980–1024

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■ Approaches to antifungal therapies and their effectiveness among patients with cryptococcosis

Emily W. Bratton, Nada El Husseini, Cody A. Chastain et al

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■ Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the Infectious Diseases Society of American

John R. Perfect, William E. Dismukes, Francoise Dromer, et al

Clin Infect Dis. 2010 Feb 1; 50(3): 291–322

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■ Cutaneous cryptococcosis due to Cryptococcus gattii in a patient on chronic corticotherapy.

Bellissimo-Rodrigues, Fernando et al.

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■ Ocorrência de Cryptococcus neoformans em excretas de pombos na cidade de Pelotas, Estado do Rio Grande do Sul.

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■ Consenso em criptococose: 2008

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■ Suscetibilidade a antifúngicos de variedades de Cryptococcus neoformans isoladas de pacientes em hospital universitário.

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■ Paniculite criptocócica em transplantado renal.

Trope, Beatriz M. et al.

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■ Amaurose bilateral por menigoencefalite criptocócica: relato de caso

Aragão, Ricardo Evangelista Marrocos de et al.

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■ Técnicas histopatológicas no diagnóstico de criptococose por Cryptococcus deficiente de cápsula: relato de caso.

Gazzoni, Alexandra Flávia, Pegas, Karla Lais and Severo, Luiz Carlos

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■ Criptococose: estudo clínico-epidemiológico, laboratorial e das variedades do fungo em 96 pacientes.

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■ Dr Paulo Fernando Leite

Cardiologia/Prevenção Cardiovascular

Estratificação de Risco Cardiovascular

Novo endereço:

Consultório: Rua Padre Rolim 815/sala 601

Tel: 33245518 (Consulta Particular/Unimed)

– Centro Médico Unimed BH/Contagem/Pedro I

Belo Horizonte/MG/Brasil

CRMMG: 7026

Email: pfleite1873@gmail.com

Hematologia: Diretrizes Médicas Online (Hematology: Guidelines)

Por Paulo Leite 12/08/2019

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