Síndrome das Pernas Inquietas Online (Restless Legs syndrome)

 

¨A síndrome das pernas inquietas (SPI) é uma condição que consiste em uma urgência em mover as pernas e que usualmente ocorre com outras sensações anormais como queimação, repuxamento ou como se existissem “insetos rastejando” dentro das pernas. Essas sensações são aliviadas pelo movimento e possuem uma apresentação circadiana piorando à tarde e à noite com alívio significativo pela manhã, independentemente da quantidade de movimento. A síndrome tem como característica fundamental desta a presença de desconforto, especialmente notável nas pernas (ainda que possa afetar outras regiões do corpo), cuja intensidade tem flutuação circadiana (aumenta à noite) e é aliviado por movimentação da parte corporal afetada. A maioria dos pacientes tem formas primárias de síndrome das pernas inquietas (SPI), onde se reconhece a presença de significativa contribuição genética. No entanto, em cerca de 1/3 dos casos SPI é secundária a outras condições, como neuropatias periféricas e outros. Esta síndrome parece ser especialmente comum entre mulheres grávidas, e não é incomum entre pacientes urêmicos ou diabéticos com neuropatia. Com o aumento do interesse nesta condição, vários estudos demonstram que existe amplo armamentário terapêutico capaz de aliviar seus sintomas. A prevalência da SPI na população aumenta com a idade e é estimada em 5,5% na população geral e em até 8,7% na população idosa, sendo mais frequentemente encontrada em pessoas do sexo feminino. Os sintomas às vezes se resolvem após a correção da anemia ferropriva coexistente, podendo responder a fármacos como agonistas da dopamina (terapia de escolha), levodopa, gabapentina, pregabalina, clonazepam ou opiódes¨

 

Restless legs syndrome in Parkinson’s disease and increased cardiovascular risk.

Silva, Maren de Moraes e et al.

Arq. Neuro-Psiquiatr., Nov 2018, vol.76, no.11, p.731-735

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018001100731&lng=en&nrm=iso&tlng=en

 

Restless legs syndrome and Parkinson disease: a causal relationship between the two disorders?

Luigi Ferini-Strambi, Giulia Carli, Francesca Casoni, Andrea Galbiati

Front Neurol. 2018; 9: 551

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066514/

 

The appropriate use of opiods in the treatment of refractory restless legs syndrome

M H Silber, P M Becker, M J Buchfuher et al

Mayo Clinic Proceedings 2018, vol 93 (1): 56-67

https://www.mayoclinicproceedings.org/article/S0025-6196(17)30825-X/fulltext

 

Restless legs syndrome and poor sleep quality in obese children and adolescents

Rıza Taner Baran, Müge Atar, Özgür Pirgon, Serkan Filiz, Meral Filiz

J Clin Res Pediatr Endocrinol. 2018 Jun; 10(2): 131–138

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985382/

 

Prevalence and Clinical Characteristics of the Restless Legs Syndrome (RLS) in Patients Diagnosed with Attention-Deficit Hyperactivity Disorder (ADHD) in Antioquia

Sierra Montoya, Ana Carolina et al.

int.j.psychol.res., June 2018, vol.11, no.1, p.58-69

http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S2011-20842018000100058&lng=en&nrm=iso&tlng=en

 

Investigation of alexithymia and levels of anxiety and depression among patients with restless legs syndrome

Onur Yilmaz, Yildizhan Şengül, Hakan Serdar Şengül et al

Neuropsychiatr Dis Treat. 2018; 14: 2207–2214.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120575/

 

Efectos de la rotigotina sobre la sintomatología, calidad de vida e higiene de sueño en el síndrome de piernas inquietas en hemodiálisis.

Esteve, Vicent et al.

Nefrología (Madr.), Feb 2018, vol.38, no.1, p.79-86

http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0211-69952018000100079&lng=en&nrm=iso

 

Management of restless legs syndrome in chronic liver disease: a challenge for the correct diagnosis and therapy

Rita Moretti, Paola Caruso, Marzia Tecchiolli, Silvia Gazzin, Claudio Tiribelli

World J Hepatol. 2018 Mar 27; 10(3): 379–38

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871858/
The association between vitamin D level and restless legs syndrome: a population-based case-control study

Siraj Wali, Samah Alsafadi, Bahaa Abaalkhail et al

J Clin Sleep Med. 2018, vol 14(4): 557–564

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886433/

 

Central disorders of hypersomnolence, restless legs syndrome, and surgery with general anesthesia: patient perceptions

LaBarbera V, García PS, Bliwise DL, Trotti LM.

Front Hum Neurosci. 2018, vol 20;12:99

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869929/

 

Peripheral dopamine in restless legs syndrome

Mitchell UH, Obray JD, Hunsaker E et al

Front Neurol. 2018, vol 15;9:155

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862810/

 

Clinical and electrophysiological impact of repetitive low-frequency transcranial magnetic stimulation on the sensory-motor network in patients with restless legs syndrome

Lanza G, Cantone M, Aricò D, Lanuzza B, Cosentino FII et al

Ther Adv Neurol Disord. 2018, vol 11:1756286418759973

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833163/

 

Symptom persistent after iron normalization in women with restless legs syndrome

Bang YR, Jeon HJ, Park HY, Yoon IY.

Psychiatry Investig. Feb 2018

 

Altered brain functional connectome in migraine with and without restless legs syndrome: a resting-state functional MRI study

Yang FC, Chou KH, Hsu AL, Fuh JL, Lirng JF, Kao HW, Lin CP, Wang SJ.

Front Neurol. 2018, vol 30;9:25

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797592/

 

Restless legs syndrome in dialysis patients: Does the dialysis modality influence its occurrence and severity?

Andreia Freire de Menezes, Douglas Rafanelle Moura de Santana Motta et al

Int J Nephrol. 2018; 2018: 1414568

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845496/

 

Iron and restless legs syndrome: treatment, genetics and pathophysiology

James R. Connor, Stephanie Patton, Konrad Oexle, Richard Alle

Sleep Med. 2017 Mar; 31: 61–70

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334282/

 

Restless legs syndrome and cardiovascular disease: a research roadmap

Daniel J. Gottlieb, Virend Somers, Naresh Punjabi, John W. Winkelman

Sleep Med. 2017 Mar; 31: 10–1

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334194/

 

Identification of novel risk loci for restless legs syndrome in genome-wide associations studies in individuals of European ancestry: a meta-analysis

Barbara Schormair, Chen Zhao, Steven Bell et al

Lancet Neurol. 2017 Nov; 16(11): 898–907

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755468/

 

Validation of a leg movements count and periodic leg movements analysis in a custom polysomnography system

BMC Neurol. 2017; 17: 42

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324307/

 

Restless legs syndrome and sleep-wake disturbance in pregnancy

Galit Levi Dunietz, Lynda D. Lisabeth, Kerby Shedden et al

J Clin Sleep Med. 2017 Jul 15; 13(7): 863–870

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482577/

 

Brain imaging and networks in restless legs syndrome

Giovanni Rizzo, Xu Li, Sebastiano Galantucci, Massimo Filippi, Yong Won Ch

Sleep Med. 2017 Mar; 31: 39–48

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846689/

 

F-wave duration as a specific and sensitive tool for the restless legs syndrome/Willis-Ekbom disease

Patrizia Congiu, Maria Livia Fantini, Giulia Milioli et al

J Clin Sleep Med. 2017 Mar 15; 13(3): 369–375

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337583/

 

Effect of mineral and bone metabolism on restless legs syndrome in hemodialysis patients

Precil D.M.M. Neves, Fabiana G. Graciolli et al

J Clin Sleep Med. 2017 Jan 15; 13(1): 89–94.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181620/

 

Symptoms of restless legs syndrome in biological caregivers of children with autism spectrum disorders

Maureen Russell, Carol Baldwin, Darya McClain et al

J Clin Sleep Med. 2017 Jan 15; 13(1): 105–113

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181600/

 

A four-year longitudinal study on restless legs syndrome in Parkinson disease

M Moccia, R Erro, M Picillo et AL

Sleep 2016, vol 39 (2): 405-412

https://academic.oup.com/sleep/article/39/2/405/2418012

 

Guidelines of the first-line treatment of restless legs syndrome/Willis-Ekbom disease, prevention and treatment of dopaminergic augmentation: a combined task force the IRLSSG, EURLSSG, and the RLS-foundation

D Garcia-Borreguero, M H Silber, J W Winkelman et al

Sleep Medicine may 2016, pages 1-11

https://www.sciencedirect.com/science/article/pii/S1389945716000563

 

Practice guideline summary: treatment of restless legs syndrome in adults: report of the guideline development, dissemination, and implementation subcommittee of the American Academy of Neurology

John W. Winkelman, Melissa J. Armstrong, Richard P. Allen et al

Neurology. 2016 Dec 13; 87(24): 2585–2593

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206998/

 

Rating of daytime and nighttime symptoms in RLS: validation of the RLS-6 scale of restless legs syndrome/Willis-Ekbom disease

R Kohnen, P Martinez-Martin, H Benes et al

Sleep Medicine april 2016, vol 20: 116-122

https://www.sciencedirect.com/science/article/pii/S1389945715020304

 

Síndrome de piernas inquietas o enfermedad de Willis Ekbom.

Calle Lopez, Yamile, Montes Gaviria, Maria Isabel and Toro Perez, Maria Eugenia

Acta Neurol Colomb., Oct 2016, vol.32, no.4, p.347-35

http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-87482016000400013&lng=en&nrm=iso

 

Restless legs syndrome associated with major diseases: a systematic review and new concepts

Claudia Trenkwalder, Richard Allen, Birgit Högl et al

Neurology. 2016 Apr 5; 86(14): 1336–1343

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826337/

 

Prevalência de síndrome das pernas inquietas em pacientes com demência: uma atualização.

Ribeiro, Rafaela Andreas S et al.

  1. bras. psiquiatr., Mar 2016, vol.65, no.1, p.89-93

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0047-20852016000100089&lng=pt&nrm=iso

 

Síndrome de piernas inquietas (enfermedad de Willis-Ekbom)seguimiento a largo plazo de una serie de pacientes.

Miranda C, Marcelo and Hudson A, Lorena

Rev. méd. Chile, Dic 2016, vol.144, no.12, p.1561-1566

https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0034-98872016001200007&lng=en&nrm=iso

 

The relationship of restless legs syndrome to history of pregnancy-induced hypertension

Kim E. Innes, Sahiti Kandati, Kathryn L. Flack, et al

J Womens Health (Larchmt) 2016 Apr 1; 25(4): 397–408

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834515/

 

Diagnostic accuracy of behavioral, activity, ferritin, and clinical indicators of restless legs syndrome

Kathy C. Richards, James E. Bost, Valerie E. Rogers et al

Sleep. 2015 Mar 1; 38(3): 371–380

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335520/

 

Brazilian consensus on guidelines for diagnosis and treatment for restless legs syndrome.

Fröhlich, Alan Christmann et al.

Arq. Neuro-Psiquiatr., Mar 2015, vol.73, no.3, p.260-28

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000300260&lng=pt&nrm=iso&tlng=en

 

Excessively crying infants are more common among children of parents with restless legs syndrome

Pereira Jr, José Carlos, Hallinan, Márcia Pradella and Pessoa, José Hugo de Lins

MedicalExpress (São Paulo, online), Dec 2015, vol.2, no.6

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2358-04292015000600004&lng=pt&nrm=iso&tlng=en

 

Restless legs syndrome and pregnancy: a review

Prachaya Srivanitchapoom, Sanjay Pandey, Mark Hallett

Parkinsonism Relat Disord. 2014 Jul; 20(7): 716–722

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058350/

 

The relationship among restless legs syndrome (Willis-Ekbom disease), hypertension, cardiovascular disease, and cerebrovascular disease

Luigi Ferini-Strambi, Arthur S. Walters, Domenic Sica

J Neurol. 2014; 261(6): 1051–1068

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057632/

 

Childhood restless legs syndrome.

Pereira Jr., Jose Carlos, Pradella-Hallinan, Márcia and Alves, Rosana Cardoso

MedicalExpress (São Paulo, online), June 2014, vol.1, no.3, p.116-122

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2358-04292014000300116&lng=pt&nrm=iso&tlng=en

 

Comorbidities, medications and depressive symptoms in patients with restless legs syndrome and migraine

Ferreira, Karen S. et al.

Arq. Neuro-Psiquiatr., Feb 2013, vol.71, no.2, p.87-91

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013000200006&lng=pt&nrm=iso

 

The treatment of restless legs syndrome and periodic limb movement disorder in adults – an updte for 2012: practice parameters with an evidence-based systematic review and meta-analyses: An American Academy of Sleep Medicine Clinical Practice Guideline

  1. Nisha Aurora, David A. Kristo, Sabin R. Bista, James A. Rowley, Rochelle S. Zak, Kenneth R. Casey, Carin I. Lamm, Sharon L. Tracy, Richard S. Rosenberg

Sleep. 2012 Aug 1; 35(8): 1039–106

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397811/

 

Epidemiology of restless legs syndrome

Maurice M. Ohayon, Ruth O’Hara, Michael V. Vitiello

Sleep Med Rev. 2012 Aug; 16(4): 283–295

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204316/

 

Algorithms for the diagnosis and treatment of restless legs syndrome in primary care

D Garcia-Borreguero, P Stillman, H Benes et AL

BMC Neurol 2011, vol 11: 28

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056753/

 

Prevalence of restless legs syndrome in North American and Western

K E Innes, T K Selfe, P Agarwal

Sleep Med 2011, vol 12 (7): 623-634

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634567/

 

Evolution of non-treated restless legs syndrome.

Rodrigues, Raimundo Nonato Delgado et al.

Arq. Neuro-Psiquiatr., Mar 2009, vol.67, no.1, p.16-20

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000100005&lng=en&nrm=iso&tlng=en

 

Restless legs syndrome

M Bayard, T Avonda

Am Fam Physician 2008, vol 78 (2): 235-240

https://www.aafp.org/afp/2008/0715/p235.html

 

Síndrome das pernas inquietas: diagnóstico e tratamento. Opinião de especialistas brasileiros.

Grupo Brasileiro de Estudos, Síndrome das Pernas Inquietas.

Arq. Neuro-Psiquiatr., Set 2007, vol.65, no.3a, p.721-727

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000400035&lng=en&nrm=iso

 

Restless leg syndrome: Is it a real problem?

P E Cotter, S T O´Keeffe

Ther Clin Risk Manag 2006, vol 2 (4): 465-475

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1936366/

 

by Dr Paulo Fernando Leite

Cardiologia/Prevenção Cardiovascular

Estratificação de Risco Cardiovascular

Av Contorno 8351 – Conj 01

Belo Horizonte/MG/Brasil

Tel: 31 32919216   2917003   3357229

(- consulta particular –)

CRMMG: 7026

Email: pfleite1873@gmail.com

Top Ten Novos & Importantes Sites Medicina/Brasil

 

Anel de Ferrara – Moderno e Seguro Tratamento para o Ceratocone

http://www.aneldeferrara.com.br/

 

Associação Brasileira de Medicina Legal e Perícias Médicas

https://abmlpm.org.br/

 

Blog Medicina Baseada em Evidências

http://medicinabaseadaemevidencias.blogspot.com/

 

Cardiômetro – Mortes por Doenças Cardiovasculares no Brasil

http://www.cardiometro.com.br/

 

Gerosaúde/USP

http://www.gerosaude.com.br/inicial/default.asp

 

Sociedade Brasileira de Genética Médica

http://www.sbgm.org.br/

 

Sociedade Brasileira de Hansenologia

http://www.sbhansenologia.org.br/

 

Escolas Médicas do Brasil

https://www.escolasmedicas.com.br/

 

Sociedade Brasileira de Dengue/Arboviroses

https://www.sbd-a.org/

 

Sociedade Brasileira de Medicina de Família e Comunidade

https://www.sbmfc.org.br/

 

Feliz Ano Novo

Paulo Fernando Leite