Blog - INTERNET MÉDICA

CardioPsiquiatria Online (CardioPsychiatry)

Por Paulo Leite 13/09/2018

■ Diferenças por sexo na ansiedade e depressão após infarto agudo do miocárdio

Serpytis, Pranas et al

Arq. Bras. Cardiol., 2018

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018005012104&lng=pt&nrm=iso&tlng=pt

■ The heart of the matter: in search of causal effects of depression on somatic diseases

Roest AM, de Jonge P.

BMC Med. 2018 Aug 23;16(1):14

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106936/

■ The intriguing relationship between coronary heat disease and mental disorders

Marc De Hert, Johan Detraux, Davy Vancampfort

Dialogues Clin Neurosci. 2018 Mar; 20(1): 31–40

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016051/

■ Fatores psicossociais associados à doença cardíaca e manejo clínico psicológico: percepção de psicólogos e paciente

Knebel, Indiara Lucy and Marin, Angela Helena

Rev. SBPH, Jun 2018, vol.21, no.1, p.112-131

http://pepsic.bvsalud.org/scielo.php?script=sci_arttext&pid=S1516-08582018000100007&lng=pt&nrm=iso

■ Cardiovascular risk and bipolar disorder: factors associated with a positive coronary calcium score in patients with bipolar disorder type 1.

Wageck, Aline R. et al.

Rev. Bras. Psiquiatr., June 2018, vol.40, no.2, p.163-168

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462018000200163&lng=pt&nrm=iso

■ Symptoms of anxiety and depression are related to cardiovascular responses to active, but not passive, coping tasks.

Yuenyongchaiwat, Kornanong, Baker, Ian S. and Sheffield, David

Rev. Bras. Psiquiatr., June 2017, vol.39, no.2, p.110-117

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462017000200110&lng=pt&nrm=iso

■ Diagnostic accuracy of screening tests and treatment for post-acute coronary syndrome depression: a systematic review

J A Niewsma, J W Williams, N Namdari et al

Annals of Internal Medicine nov 2017

http://annals.org/aim/fullarticle/2662096/diagnostic-accuracy-screening-tests-treatment-post-acute-coronary-syndrome-depression

■ Sintomas Depressivos Persistentes são Preditores Independentes de Início de Inflamação de Baixo Grau em Indivíduos Saudáveis

Franco, Fábio Gazelato de Mello et al.

Arq. Bras. Cardiol., Aug 2017, vol.109, no.2, p.103-10

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2017000800103&lng=pt&nrm=iso&tlng=pt

■ Depressão Maior e Fatores Relacionados na Síndrome Coronariana Aguda

Figueiredo, Jose Henrique Cunha et al.

Arq. Bras. Cardiol., Mar 2017, vol.108, no.3, p.217-227

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2017000300217&lng=pt&nrm=iso&tlng=pt

■ Fear and distress disorders as predictors of heart disease: a temporal perspective

AM Roest, P de Jonge, C Lim, DJ Stein et al

J Psychosom Res. 2017 May; 96: 67–7

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674522/

■ Arterial stiffness is associated with depression in middle-aged men – The Maastricht Study

Veronica Onete, Ronald M. Henry, Simone J.S. Sep et al

J Psychiatry Neurosci. 2018 Mar; 43(2): 111–119

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837883/

■ Predictive value of depression and anxiety for long-term mortality: differences in outcome between acute coronary syndrome and stable angina pectoris

T A J de Jager, K Dulfer, S Radhoe et al

International Journal of Cardiology 2018, vol 250: 43-48

https://www.internationaljournalofcardiology.com/article/S0167-5273(17)31511-5/fulltext

■ Stress and achievement of Cardiovascular Health Metrics: The American Heart Association Life´s Simple 7 in Blacks of the Jackson Heart Study

LaPrincess C. Brewer, Nicole Redmond, Joshua P. Slusser et al

J Am Heart Assoc. 2018 Jun 5; 7(11): e008855

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015384/

■ Perceived social isolation and outcomes in patients with heart failure

Sheila M. Manemann, Alanna M. Chamberlain, Véronique L. Roger et al

J Am Heart Assoc. 2018 Jun 5; 7(11): e008069

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015354/

■ Atrial fibrillation in patients with severe mental disorders and the risk of stroke, fatal thromboembolic events and bleeding: a nationwide cohort study

Mette Søgaard, Flemming Skjøth, Jette Nordstrøm Kjældgaard et al

BMJ Open. 2017; 7(12): e018209

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728273/

■ Female psychological adjustment following an acute coronary syndrome

J Prata, A Q Martins, S Ramos et AL

Acta Médica Portuguesa 2017, vol 30 (5)

https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/7871/5043

■ Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics

Kalyanam Shivkumar, Olujimi A. Ajijola, Inder Anand et al

J Physiol. 2016 Jul 15; 594(14): 3911–3954

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945719/

■ Depression, anxiety and major adverse cardiovascular and cerebrovascular events in patients following coronary artery bypasse graft surgery: a five year longitudinal cohort study

Phillip J. Tully, Helen R. Winefield, Robert A. Baker et al

Biopsychosoc Med. 2015; 9: 14

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445298/

■ Depressão Maior e Fatores Relacionados na Síndrome Coronariana Aguda

Figueiredo, Jose Henrique Cunha et al

Arq. Bras. Cardiol., Mar 2017, vol.108, no.3, p.217-227

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2017000300217&lng=pt&nrm=iso&tlng=pt

■ Depressão Maior e Fatores Relacionados na Síndrome Coronariana Aguda

Figueiredo, Jose Henrique Cunha et al

Arq. Bras. Cardiol., Mar 2017, vol.108, no.3, p.217-227

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2017000300217&lng=pt&nrm=iso&tlng=pt

■ Association between depressive symptoms and exercise capacity in patients with heart disease: a meta-analysis

Papasavvas, Theodoros; Alhashemi, Mohammad; Micklewright, Dominic

Journal of Cardiopulmonary Rehabilitation & Prevention 2017. vol 37(4):239-249

http://journals.lww.com/jcrjournal/Fulltext/2017/07000/Association_Between_Depressive_Symptoms_and.1.aspx

■ Relevância de fatores psicossociais e da ocorrência de choques do cardioversor-desfibrilador implantável na percepção da doença cardíaca como ameaça: um estudo COMFORT-CDI.

Guimarães, Tathiane Barbosa et al.

Rev. SBPH, Jun 2016, vol.19, no.1, p.117-13

http://pepsic.bvsalud.org/scielo.php?script=sci_arttext&pid=S1516-08582016000100008&lng=pt&nrm=iso

■ Attachment anxiety predicts depression and anxiety sumptoms following coronary artery bypass graft surgery

Tara Kidd, Lydia Poole, Amy Ronaldson, Elizabeth Leigh et al

Br J Health Psychol. 2016 Nov; 21(4): 796–811

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082502/

■ Biopsychosocial-spiritual factors impactient referral to and participation in cardiac rehabilitationfor African American Patients: a systematic review

Koehler Hildebrandt, Aubry N.; Hodgson, Jennifer L.; Dodor, Bernice A.; More

Journal of Cardiopulmonary Rehabilitation & Prevention . vol 36(5):320-330, September/October 2016.

http://journals.lww.com/jcrjournal/Fulltext/2016/09000/Biopsychosocial_Spiritual_Factors_Impacting.2.aspx

■ Endurance- and resistance- trained men exhibit lower cardiovascular responses to psychosocial stress than untrained men

Peter Gröpel, Maren Urner, Jens C. Pruessner, Markus Quirin

Front Psychol. 2018; 9: 852

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992644/

■ Blood pressure and fibrinogen responses to mental stress as predictors of incident hypertension over an 8-year period

A Steptoe, M Kivimäki, G Lowe et al

Annals of Behavioral Medicine 2016, vol 50 (6)

https://academic.oup.com/abm/article/50/6/898/4562667

■ A role for behavior in the relationship between depression hostility and cardiovascular disease incidence, mortality, and all-cause mortality: the Prime Study

PRIME study group

Annals of Behavioral Medicine 2016, vol 50 (4): 582-591

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933737/

■ Regular exercise behavior and intention and symptoms of anxiety and depression in coronary heart disease patients across Europe: results from the EUROASPIRE III survey

C Prugger, J Wellmann, J Heidrich

European Journal of Preventive Cardiology set 2016

http://journals.sagepub.com/doi/full/10.1177/2047487316667781

■ Treatment of anxiety in patients with coronary heart disease: rationale and design of the UNWIND randomized clinical trial

J A Blumenthal, B J Feger, P J Smith et al

Am Heart J 2016, vol 176: 53-62

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900181/

■ State of the Art Review: Depression, Stress, Anxiety and Cardiovascular Disease

Beth E. Cohen, Donald Edmondson, Ian M. Kronish

Am J Hypertens. 2015 Nov; 28(11): 1295–1302

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612342/

■ Treatment of affective disorders in cardiac disease

Nicole Mavrides, Charles B. Nemeroff

Dialogues Clin Neurosci. 2015 Jun; 17(2): 127–140

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518697/

■ Position paper on the importance of psychosocial factors in cardiology: Update 2013

Karl-Heinz Ladwig, Florian Lederbogen, Christian Albus et al

Ger Med Sci. 2014; 12: Doc09

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012565/

■ The link between cardiovascular risk, Alzheimer’s disease, and mild cognitive impairment: support from recent functional neuroimaging studies.

Ferreira, Luiz K. et al.

Rev. Bras. Psiquiatr., Dec 2014, vol.36, no.4, p.344-35

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462014000500344&lng=pt&nrm=iso

■ Coexisting anxiety and depression symptoms in patients with heart failure

Rebecca L. Dekker, Terry A. Lennie, Lynn V. Doering, Misook L. Chung, Jia-Rong Wu, Debra K. Moser

Eur J Cardiovasc Nurs. 2014 Apr; 13(2): 168–17

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992982/

■ Cardiovascular risk factors in outpatients with bipolar disorder: a report from the Brazilian Research Network in Bipolar Disorder

Gomes, Fabiano A. et al.

Rev. Bras. Psiquiatr., June 2013, vol.35, no.2, p.126-130

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462013000200126&lng=pt&nrm=iso

■ Associations between DSM-IV mental disorders and subsequent heart disease onset: beyond depression

Kate M. Scott, Peter de Jonge, Jordi Alonso et al

Int J Cardiol. 2013 Oct 15; 168(6)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886238/

■ Association of anxiety and depression with all-cause mortality in individuals with coronary heart disease

Lana L. Watkins, Gary G. Koch, Andrew Sherwood et al

Jonathan R.T. Davidson, Christopher O’Connor, Michael H. Sketch

J Am Heart Assoc. 2013 Apr; 2(2): e000068

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647264/

■ Fatores de risco cardiovascular em alcoolistas em tratamento.

Toffolo, Mayla Cardoso Fernandes, Marliére, Cláudia Aparecida and Nemer, Aline Silva de Aguiar

bras. psiquiatr., Jun 2013, vol.62, no.2, p.115-123

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0047-20852013000200004&lng=pt&nrm=iso

■ Psychological fators and coronary heart disease

Zohreh Khayyam-Nekouei, Hamidtaher Neshatdoost, Alireza Yousefy, Masoumeh Sadeghi, Gholamreza Manshaee

ARYA Atheroscler. 2013 Jan; 9(1): 102–111.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653260/

■ Association of psychiatry history and type D personality with symptoms of anxiety, depression, and health status prior to ICD implantation

Annemieke H. Starrenburg, Karin Kraaier, Susanne S. Pedersen et al

Int J Behav Med. 2013; 20(3): 425–43

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767890/

by Dr Paulo Fernando Leite

■ Cardiologia/Prevenção Cardiovascular

■ Estratificação de Risco Cardiovascular

Av Contorno 8351 – Conj 01

Belo Horizonte/MG/Brasil

Tel: 31 32919216 2917003 3357229

(- consulta particular –)

CRMMG: 7026

Email: pfleite1873@gmail.com

Síndrome Neuroléptica Maligna Online (Neuroleptic Malignant Syndrome)

Por Paulo Leite 11/09/2018

¨A Síndrome Neuroléptica Maligna (SNM) é uma das principais complicações do uso de antipsicóticos, relativamente rara, porém potencialmente fatal, podendo levar ao óbito em 10 a 20% dos casos. Esta síndrome é caracterizada pelo desenvolvimento de rigidez muscular grave e hipertermia, associados a pelo menos dois outros sintomas: diaforese, disfagia, tremor, incontinência, confusão mental/coma, mutismo, taquicardia/taquipneia, pressão arterial elevada ou instável, leucocitose; elevação da creationofosfoquinase(CPK). Os fatores de risco para desenvolvimento da SNM incluem: episódio prévio de SNM, desidratação, agitação, ingesta oral pobre, ambientes com temperatura elevada, estresse emocional, umidade e uso concomitante de lítio, agentes anticolinérgicos e alguns antidepressivos. O tratamento desta síndrome inclui suporte clínico, suspensão do antipsicótico ou outro agente causal, e ocasionalmente uso de drogas como agonistas dopaminérgicos (Bromocriptina) e Dantrolene.¨

. ■ Diagnostic, treatment, and system challenge in the management of recurrent neuroleptic malignant syndrome on a general medical services

Verma K, Jayadeva V, Serrano R, Sivashanker K.

Case Rep Psychiatry. 2018 Jun 11;2018:4016087

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016165/

. ■ A neuroleptic malignant syndrome without rigidity

İlker Özdemir, Erkan Kuru, Yasir Safak, Rıza Gökçer Tulacı

Psychiatry Investig. 2018 Feb; 15(2): 226–229.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900391/

. ■ Neuroleptic malignant syndrome following reintroduction of an antipsychotic after overdose

T Korchia, G Blackman, M Cermolacce, R Richieri

BMJ Case Reports july- aug 2018

http://casereports.bmj.com/content/2018/bcr-2017-223922.full

. ■ Forced diuresis and expedient blood pressure control in the management of quetiapine induced neuroleptic malignant syndrome: a case report

Neville Aquilina, Vincent Bugeja

Open Access Maced J Med Sci. 2018 Jul 20; 6(7): 1267–1270

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062291/

. ■ Bitemporal ultra-brief pulse electroconvulsive therapy for the treatment of neuroleptic malignant syndrome in a first psychotic episode: a case report.

Marcolin, Kathy Aleixo et al.

Trends Psychiatry Psychother., Mar 2017, vol.39, no.1, p.62-63

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2237-60892017000100062&lng=en&nrm=iso

. ■ Neuroleptic malignant syndrome in the trauma intensive care unit: diagnosis and management of a rare disease in a challenging population

Joseph David Drews, Andrew Christopher, David Clay Evans

Int J Crit Illn Inj Sci. 2017 Apr-Jun; 7(2): 119–121

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479074/

. ■ Early detection of an atypical presentation of neuroleptic malignant syndrome: a case report

Brittany Vickery, Lindsy Meadowcraft, Stephen B. Vickery

Ment Health Clin. 2017 May; 7(3): 137–142

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007570/

. ■ Neuroleptic malignant syndrome: an easily overlooked neurologic emergency

Ramadhan Oruch, Ian F Pryme, Bernt A Engelsen, Anders Lund

Neuropsychiatr Dis Treat. 2017; 13: 161–175

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5248946/

. ■ Neuroleptic malignant syndrome with thyroid disorder: na unusual case report

Fan Zhang, Parisa Kanzali, Vadim Rubin, Chris Paras, Joel Goldman

Medicine (Baltimore) 2017 Sep; 96(39): e8191

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626322/

. ■ Drug information update: atypical antipsychotics and neuroleptic malignant syndrome: nuances and pragmatics of the association

Siddharth Sarkar, Nitin Gupta

BJPsych Bull. 2017 Aug; 41(4): 211–216

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537576/

. ■ Atypical neuroleptic malignant syndrome associated with use of clozapine

Quevedo-Florez Leonardo, Granada-Romero Juliana, Camargo-Arenas Juan Fernando

Case Rep Emerg Med. 2017; 2017: 217437

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337851/

. ■ Síndrome neuroléptica maligna em paciente emu so de olanzapina – relato de caso

B Mendonça, G S Mendonça, M Quitete et al

Revista Científica da FMC 2016, vol 11 (1)

http://www.fmc.br/wp-content/uploads/2016/10/Rev-Cient-FMC-1-2016-26-29.pdf

. ■ Atypical neuroleptic malignant syndrome

Ann Collins, Drew Davies, Sharmila Menon

BMJ Case Rep. 2016; 2016: bcr201621490

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932411/

. ■ Second-generation antipsychotics and neuroleptic malignant syndrome: systematic review and case report analysis

Martino Belvederi Murri, Argentina Guaglianone, Michele Bugliani et al

Drugs R D. 2015 Mar; 15(1): 45–62

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359181/

. ■ Neuroleptic malignant syndrome: a review from a clinically oriented perspective

L Tse, A M Barr, V Scarapicchia, F Vila-Rodriguez

Curr Neuropharmacol 2015, vol 13 (3): 395-406

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812801/

. ■ A rare case of neuroleptic malignant syndrome withut elevated serum creatine kinase

Koichi Nisijima, Katutoshi Shioda

Neuropsychiatr Dis Treat. 2014; 10: 403–407

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938441/

. ■ Serotonin syndrome versus neuroleptic malignant syndrome: a challenging clinical quandary

Rupal Dosi, Annirudh Ambaliya, Harshal Joshi, Rushad Patell

BMJ Case Rep. 2014; 2014: bcr2014204154

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069678/

. ■ Delirium followed by neuroleptic malignant syndrome in rehabilitation setting. Is it anger reaction before discharge?

Rafat M Al Owesie, Asirvatham Alwin Robert

Pan Afr Med J. 2013; 15: 26

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758850/

. ■ Antipsychotic dose escalation as a trigger for neuroleptic malignant syndrome (NMS): literature review and case series report

Julie Langan, Daniel Martin, Polash Shajahan, Daniel J Smith

BMC Psychiatry. 2012; 12: 214.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546951/

. ■ Catatonía periódica o síndrome neuroléptico maligno: claves para un reto diagnóstico.

Sánchez García, Javier, Rezende Borges, Livia de and Vera López, Ignacio

Rev. Asoc. Esp. Neuropsiq., Set 2012, vol.32, no.115, p.597-60

http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0211-57352012000300010&lng=es&nrm=iso

. ■ Neuroleptic malignant syndrome

Moscovich, Mariana et al.

Arq. Neuro-Psiquiatr., Oct 2011, vol.69, no.5, p.751-755

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000600005&lng=en&nrm=iso&tlng=en

. ■ Neuroleptic malignant syndrome: a neuroimmunologic hypothesis

Rebecca E. Anglin, Patricia I. Rosebush, Michael F. Mazurek

CMAJ. 2010 Dec 14; 182(18): E834–E838

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001529/

. ■ Neuroleptic malignant syndrome in children and adolescents on atypical antipsychotic medication: a review

Rachel Neuhut, Jean-Pierre Lindenmayer, Raul Silva

J Child Adolesc Psychopharmacol. 2009 Aug; 19(4): 415–422

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861947/

. ■ The problem of atypical neuroleptic malignant syndrome: a case report

Brendan T. Carroll, Susan A. Surber

Psychiatry (Edgmont) 2009 Jul; 6(7): 45–47

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728938/

. ■ Síndrome neuroléptica maligna de paciente em uso de olanzapina

Medeiros, Fabrício Lins de et al.

bras. psiquiatr., 2008, vol.57, no.2, p.145-147

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0047-20852008000200012&lng=en&nrm=iso

. ■ Neuroleptic malignant syndrome induced by atypical neuroleptics and responsive to lorazepam

Adeeb Yacoub, Andrew Francis

Neuropsychiatr Dis Treat. 2006 Jun; 2(2): 235–240.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671780/

. ■ Uso de olanzapina e eletroconvulsoterapia em um paciente com esquizofrenia catatônica refratária e antecedentes de síndrome neuroléptica maligna

Alvarenga, Pedro Gomes de and Rigonatti, Sérgio Paulo

Rev. psiquiatr. Rio Gd. Sul, Dez 2005, vol.27, no.3, p.324-327

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-81082005000300012&lng=en&nrm=iso

. ■ Neuroleptic malignant syndrome: diagnostic and therapeutic dilemmas

Abebaw Fekadu, Jonathan I. Bisson

Behav Neurol. 2005; 16(1): 9–13

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478846/

. ■ Síndrome neuroléptico maligno y poliserositis en paciente usuaria de clozapina: una asociación infrecuente

Eymin L, Gonzalo et al.

Rev. méd. Chile, Oct 2005, vol.133, no.10, p.1225-1228

https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0034-98872005001000012&lng=es&nrm=iso

. ■ Síndrome neuroléptico maligno e hiponatremia relacionados con una intoxicación por risperidona