Síndrome das Pernas Inquietas Online (Restless Legs syndrome)
¨A síndrome das pernas inquietas (SPI) é uma condição que consiste em uma urgência em mover as pernas e que usualmente ocorre com outras sensações anormais como queimação, repuxamento ou como se existissem “insetos rastejando” dentro das pernas. Essas sensações são aliviadas pelo movimento e possuem uma apresentação circadiana piorando à tarde e à noite com alívio significativo pela manhã, independentemente da quantidade de movimento. A síndrome tem como característica fundamental desta a presença de desconforto, especialmente notável nas pernas (ainda que possa afetar outras regiões do corpo), cuja intensidade tem flutuação circadiana (aumenta à noite) e é aliviado por movimentação da parte corporal afetada. A maioria dos pacientes tem formas primárias de síndrome das pernas inquietas (SPI), onde se reconhece a presença de significativa contribuição genética. No entanto, em cerca de 1/3 dos casos SPI é secundária a outras condições, como neuropatias periféricas e outros. Esta síndrome parece ser especialmente comum entre mulheres grávidas, e não é incomum entre pacientes urêmicos ou diabéticos com neuropatia. Com o aumento do interesse nesta condição, vários estudos demonstram que existe amplo armamentário terapêutico capaz de aliviar seus sintomas. A prevalência da SPI na população aumenta com a idade e é estimada em 5,5% na população geral e em até 8,7% na população idosa, sendo mais frequentemente encontrada em pessoas do sexo feminino. Os sintomas às vezes se resolvem após a correção da anemia ferropriva coexistente, podendo responder a fármacos como agonistas da dopamina (terapia de escolha), levodopa, gabapentina, pregabalina, clonazepam ou opiódes¨
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■ Management of restless legs syndrome in chronic liver disease: a challenge for the correct diagnosis and therapy
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■ Restless legs syndrome in dialysis patients: Does the dialysis modality influence its occurrence and severity?
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■ Identification of novel risk loci for restless legs syndrome in genome-wide associations studies in individuals of European ancestry: a meta-analysis
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■ F-wave duration as a specific and sensitive tool for the restless legs syndrome/Willis-Ekbom disease
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■ A four-year longitudinal study on restless legs syndrome in Parkinson disease
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■ Rating of daytime and nighttime symptoms in RLS: validation of the RLS-6 scale of restless legs syndrome/Willis-Ekbom disease
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■ Restless legs syndrome associated with major diseases: a systematic review and new concepts
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■ The relationship of restless legs syndrome to history of pregnancy-induced hypertension
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■ Excessively crying infants are more common among children of parents with restless legs syndrome
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