Síndrome de Wellens Online (Wellens syndrome)

¨Descrita pela primeira vez em 1982. a síndrome de Wellens é incomum na prática médica. Constitui apresentação de síndrome coronariana aguda (SCA) de alto risco e está associada à estenose grave da porção proximal da artéria coronariana descendente anterior. Tal condição clínica se não identificada e tratada precocemente, pode evoluir para infarto agudo do miocárdio em parede anterior e óbito. Na síndrome de Wellens é observado um fenômeno de inversão da onda T observado nas derivações precordiais do eletrocardiograma nos pacientes com angina instável. Esse achado é visto no estado sem dor. Dois padrões diferentes foram descritos. O tipo A apresenta ondas T bifásicas em V2-V3 e o tipo B apresenta inversões simétricas profundas de onda T em V2-V3. Esta etiologia significa estenose crítica na artéria descendente anterior esquerda (DAE). A síndrome  é um estágio pré-infarto de estenose significativa da artéria descendente anterior esquerda (DAE), que pode levar a infarto do miocárdio extenso, da parede anterior, sem intervenção oportuna. Após o diagnóstico exige-se revascularização miocárdica imediata seguida de prevenção cardiovascular secundária. ¨

 

A pathognomonic electrocardiogram that requires urgent percutaneous intervention: a case of Wellens syndrome in a previously healthy 55-year-old male

Dilpreet Singh, Idrees Suliman, Iryna Chyshkevych, Nemer Dabage

Am J Case Rep. 2019; 20: 117–120

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364456/

 

Síndrome de Wellens, equivalente clínico de estenosis coronaria crítica

Vergara-Orduña, Fernando Iván et al.

Med. interna Méx., Ago 2018, vol.34, no.4, p.658-661

http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0186-48662018000400020&lng=es&nrm=iso

 

Atypical presentation of acute coronary syndrome and importance of Wellens´ syndrome

Kyaw Kyaw, Htun Latt, Sammy San Myint Aung et a

Am J Case Rep. 2018; 19: 199–202

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829624/

 

Wellens´ syndrome: an atypical presentation of an already silent killer

MMufti, R Joea, S Sobnosky, J Longtine

Journal of Medical Cases 2018, vol 9 (6): 173-176

https://www.journalmc.org/index.php/JMC/article/view/3096/2393

 

Dolor torácico y alteración electrocardiográfica

Paredes, Alejandro, Bittner, Alex and Vergara, Ismael

Rev Chil Cardiol, 2017, vol.36, no.2, p.154-157

https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0718-85602017000200010&lng=es&nrm=iso

 

Wellens syndrome in HIV-infected patients: two case reports

Bowei Tan, Carlos Morales-Mangual, Dan Zhao, Abdullah Khan, Hal Chadow

Medicine (Baltimore) 2017 Jun; 96(24): e7152

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478330/

 

Wellens syndrome

Debraj Das, Nawaf S. Almajed

CMAJ. 2016 Apr 19; 188(7): 529

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835285/

 

Omnious T-Wave inversions: Wellens´ syndrome

S Z M W H Oo, K Khalighi, A Kodali et al

J Community Hosp Intern Med Perspect 2016,vol 6(4)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016748/

 

Wellens´syndrome – report of two cases

Serdar Ozdemir, Tuba Cimilli Ozturk, Yalman Eyinc et al

Turk J Emerg Med. 2015 Dec; 15(4): 179–181

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882207/

 

Wellens´ syndrome in na elderly patient with dementia

Qi Zheng, Benjamin T. Galen

J Gen Intern Med. 2015 Jul; 30(7): 1035–1036

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471017/

 

Síndrome de Wellens: reconociendo el peligro.

Carvajal, Carlos A. and Ardila, Diego J.

Rev. Colomb. Cardiol., Set 2015, vol.22, no.5, p.244-248

http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-56332015000500007&lng=en&nrm=iso

 

Síndrome de Wellens

Arceo-Navarro, Adalberto et al.

Rev. Fac. Med. (Méx.), Dic 2014, vol.57, no.6, p.38-39

http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0026-17422014000600038&lng=es&nrm=iso

 

Harbinger of infarction: Wellens syndrome electrocardiographic abnormalities in the emergency department

Nicholas Sowers

Can Fam Physician. 2013, vol 59(4): 365-366

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625080/

 

Wellens´ syndrome in a 24-year-old woman

Beenish Khan, John Alexander, Krishnaraj Sinhji Rathod, Fahad Farooqi

BMJ Case Rep. 2013; 2013: bcr2013009323

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645771/

 

Red flags in electrocardiogram for emergency physicians revembering Wellens´s syndrome and upright T wave in V1

Erden Erol Ünlüer, Adnan Pınar, Hüseyin Bozdemir, Serdar Bayata, Seran Ünlüer, Özcan Yavaşi

West J Emerg Med. 2012 May; 13(2): 160–162

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415803/

 

Síndrome de Wellens: Reporte de un caso.

Machado, Federico et al.

Rev.Urug.Cardiol., Dic 2012, vol.27, no.3, p.337-340

http://www.scielo.edu.uy/scielo.php?script=sci_arttext&pid=S1688-04202012000300012&lng=es&nrm=iso

 

Síndrome de Wellens

Appel-da-Silva, Marcelo Campos et al.

Arq. Bras. Cardiol., Abr 2010, vol.94, no.4, p.e116-e11

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2010000400026&lng=en&nrm=iso

 

■ by Dr Paulo Fernando Leite

Cardiologia – Centro Médico Unimed BH

Rua Gonçalves Dias 202

Belo Horizonte/MG/Brasil

tel 40204020

CRMMG: 7026

Email: pfleite1873@gmail.com

Diabetes Mellitus: Perguntas & Respostas Online (Diabetes Mellitus: Question & Answers)

 

Unrecognised cardiovascular disease in type 2 diabetes: Is it time to act earlier?

Guntram Schernthaner, Chaim Lotan, Elina Baltadzhieva-Trendafilova et al

Cardiovasc Diabetol. 2018; 17: 145

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247507/

 

Is ischemia the only predicting cardiovascular outcomes in all diabetes mellitus patients?

Mark W. Kennedy, Enrico Fabris, Harry Suryapranata, Elvin Kedhi

Cardiovasc Diabetol. 2017; 16: 51

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397766/

 

How do we know that statins are diabeteogenic, and why? Is it an import issue in the clinical practice?

Cybulska B, Kłosiewicz-Latoszek L.

Kardiol Pol. 2018;76(8):1217-1223

https://ojs.kardiologiapolska.pl/kp/article/view/KP.a2018.0150/9886

 

Omega-3 polyunsaturated fatty acids supplementation in patients with diabetes and cardiovascular disease risk: Does really matter?

Alexander Tenenbaum, Enrique Z. Fisman

Cardiovasc Diabetol. 2018; 17: 119

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112138/

 

Abdominal subcutaneous adipose tissue: a favorable adipose depot for diabetes?

Peizhu Chen, Xuhong Hou, Gang Hu et al

Cardiovasc Diabetol. 2018; 17: 93

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020307/

 

Excess BMI in childhood: A modifiable risk fator for type 1diabetes development?

Christine Therese Ferrara, Susan Michelle Geyer, Yuk-Fun Liu et al

the Type 1 Diabetes TrialNet Study Group

Diabetes Care. 2017 May; 40(5): 698–701

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399656/

 

Does glucagon have a positive inotropic effect in the human heart?

Jesus Hernández-Cascales

Cardiovasc Diabetol. 2018; 17: 148.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258156/

 

Is FGF-23 an early indicator of atherosclerosis and cardiac dysfunction in patients with gestational diabetes?

Tuzun, Dilek et al.

Arch. Endocrinol. Metab., Oct 2018, vol.62, no.5, p.506-513

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972018000500506&lng=en&nrm=iso

 

Is fibroblast growth factor 23 a new cardiovascular risk marker in gestational diabetes?

Kizilgul, Muhammed et al.

Arch. Endocrinol. Metab., Dec 2017, vol.61, no.6, p.562-566

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972017000600562&lng=en&nrm=iso

 

Tight or less tight glycaemic targets for women with gestational mellitus for reducing maternal and perinatal morbidity? (TARGET): study protocol for a stepped wedge randomised trial

Crowther CA, Alsweiler JM, Hughes R, Brown J;

Target Study Group.

BMC Pregnancy Childbirth. 2018 Oct 29;18(1):425

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206938/

 

Identifying risk for type 2 diabetes in different age cohorts: Does one size fit all?

Maria L Alva, Thomas J Hoerger, Ping Zhang, Edward W Gregg

BMJ Open Diabetes Res Care. 2017; 5(1): e000447

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663261/

 

Neurodegeneration in diabetic retinopathy: Does it really matter?

Rafael Simó, Alan W. Stitt, Thomas W. Gardner

Diabetologia. Vol  61(9): 1902–1912

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096638/

 

Is it time to change the type 2 diabetes treatment paradigm?  Yes! GLP-1 RAs should replace metformin in the type 2 diabetes alg0rithm

Muhammad Abdul-Ghani, Ralph A. DeFronzo

Diabetes Care. 2017 Aug; 40(8): 1121–1127

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521981/

 

Declines in incidence od diabetes in the U.S. – Real Progresso or Artifact?

Elizabeth Selvin, Mohammed K. Ali

Diabetes Care. 2017 Sep; 40(9): 1139–1143

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566279/

 

Mediators of diabetic neuropathy – Is hyperglycemia the only culprit?

A Grisold, B C Callaghan, E L Feldman

Curr Opin Endocrinol Diabetes Obes2017,vol24 (2): 103-111

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831542/

 

How similar are biosimilar? What do clinicians need to know about biosimilar and follow-on insulins?

Curtis Triplitt, Debbie Hinnen, Virginia Valentine

Clin Diabetes. 2017 Oct; 35(4): 209–216

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669137/

 

Does metformin exposure before ICU stay have any impact on patients´s outcome? A retrospective cohort study of diabetic patients

Sebastien Jochmans, Jean-Emmanuel Alphonsine, Jonathan Chelly et al

Ann Intensive Care. 2017; 7: 116

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712297/

 

How´s your sugar? Evaluation of a website for aboriginal people with diabetes

Karen Adams, Anna Liebzeit, Jennifer Browne, Petah Atkinson

JMIR Diabetes. 2017 Jan-Jun; 2(1): e6

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238832/

 

Update on the impact, diagnosis, and management of cardiovascular autonomic neuropathy in diabetes: What is defined? What is new?, and What is unmet

Vincenza Spallone

Diabetes Metab J. 2019 Feb; 43(1): 3–30

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387879/

 

Can reducing sitting time in the university setting improve the cardiometabolic health of college students?

Karrie M Butler, Joyce S Ramos, Christina A Buchanan, Lance C Dalleck

Diabetes Metab Syndr Obes. 2018; 11: 603–610

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181072/

 

Is there an association between liraglutide use and female breast câncer in a real-world setting?

Donnie Funch, Kathleen Mortimer, Ling Li, et al

Diabetes Metab Syndr Obes. 2018; 11: 791–806

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254592/

 

Is surgical debridement necessary in the diabetic foot treated with photodynamic therapy?

João Paulo Tardivo, Rodrigo Serrano, Lívia Maria Zimmermann et al

Diabet Foot Ankle. 2017; 8(1): 1373552

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642141/

 

A review of insulin resistance in type 1 diabetes: Is there a place for adjunctive metformin?

Gagan Priya, Sanjay Kalra

Diabetes Ther. 2018 Feb; 9(1): 349–361

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801219/

 

Metabolic control in type 1 diabetes: Is adjunctive therapy the way forward?

Harriet Warnes, Rebecca Helliwell, Sam Matthew Pearson, Ramzi A. Ajjan

Diabetes Ther. 2018 Oct; 9(5): 1831–1851.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167310/

 

Teens with type 1 diabetes: Does their nutrition measure up?

Eleanor Race Mackey, Lyndsay O’Brecht, Clarissa S. Holmes et al

J Diabetes Res. 2018; 2018: 5094569

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146652/

 

Type 1 diabetes mellitus: Can coaching improve health outcomes?

Magalhães, Thais Pereira Costa et al.

Arch. Endocrinol. Metab., Aug 2018, vol.62, no.4, p.485-489

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972018000400485&lng=en&nrm=iso

 

Illness-specific risk-taking in adolescence: a missing piece of the nonadherence puzzle for youth with type 1 diabetes?

Rachel Wasserman, Barbara J. Anderson, David D. Schwartz

Diabetes Spectr. 2017 Feb; 30(1): 3–10.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309908/

 

■ by Dr Paulo Fernando Leite

Cardiologia – Centro Médico Unimed BH

Rua Gonçalves Dias 202

Belo Horizonte/MG/Brasil

tel 40204020

CRMMG: 7026

Email: pfleite1873@gmail.com