Síndrome das Pernas Inquietas Online (Restless Legs syndrome)

¨A síndrome das pernas inquietas (SPI) é uma condição que consiste em uma urgência em mover as pernas e que usualmente ocorre com outras sensações anormais como queimação, repuxamento ou como se existissem “insetos rastejando” dentro das pernas. Essas sensações são aliviadas pelo movimento e possuem uma apresentação circadiana piorando à tarde e à noite com alívio significativo pela manhã, independentemente da quantidade de movimento. A síndrome tem como característica fundamental desta a presença de desconforto, especialmente notável nas pernas (ainda que possa afetar outras regiões do corpo), cuja intensidade tem flutuação circadiana (aumenta à noite) e é aliviado por movimentação da parte corporal afetada. A maioria dos pacientes tem formas primárias de síndrome das pernas inquietas (SPI), onde se reconhece a presença de significativa contribuição genética. No entanto, em cerca de 1/3 dos casos SPI é secundária a outras condições, como neuropatias periféricas e outros. Esta síndrome parece ser especialmente comum entre mulheres grávidas, e não é incomum entre pacientes urêmicos ou diabéticos com neuropatia. Com o aumento do interesse nesta condição, vários estudos demonstram que existe amplo armamentário terapêutico capaz de aliviar seus sintomas. A prevalência da SPI na população aumenta com a idade e é estimada em 5,5% na população geral e em até 8,7% na população idosa, sendo mais frequentemente encontrada em pessoas do sexo feminino. Os sintomas às vezes se resolvem após a correção da anemia ferropriva coexistente, podendo responder a fármacos como agonistas da dopamina (terapia de escolha), levodopa, gabapentina, pregabalina, clonazepam ou opiódes¨

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J Clin Res Pediatr Endocrinol. 2018 Jun; 10(2): 131–138

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■ Investigation of alexithymia and levels of anxiety and depression among patients with restless legs syndrome

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■ Management of restless legs syndrome in chronic liver disease: a challenge for the correct diagnosis and therapy

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■ Restless legs syndrome in dialysis patients: Does the dialysis modality influence its occurrence and severity?

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■ Restless legs syndrome and cardiovascular disease: a research roadmap

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■ Validation of a leg movements count and periodic leg movements analysis in a custom polysomnography system

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■ Restless legs syndrome and sleep-wake disturbance in pregnancy

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■ Brain imaging and networks in restless legs syndrome

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■ Effect of mineral and bone metabolism on restless legs syndrome in hemodialysis patients

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■ Symptoms of restless legs syndrome in biological caregivers of children with autism spectrum disorders

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■ A four-year longitudinal study on restless legs syndrome in Parkinson disease

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■ Guidelines of the first-line treatment of restless legs syndrome/Willis-Ekbom disease, prevention and treatment of dopaminergic augmentation: a combined task force the IRLSSG, EURLSSG, and the RLS-foundation

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■ Practice guideline summary: treatment of restless legs syndrome in adults: report of the guideline development, dissemination, and implementation subcommittee of the American Academy of Neurology

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■ Rating of daytime and nighttime symptoms in RLS: validation of the RLS-6 scale of restless legs syndrome/Willis-Ekbom disease

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■ Síndrome de piernas inquietas o enfermedad de Willis Ekbom.

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http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-87482016000400013&lng=en&nrm=iso

■ Restless legs syndrome associated with major diseases: a systematic review and new concepts

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■ Prevalência de síndrome das pernas inquietas em pacientes com demência: uma atualização.

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■ Síndrome de piernas inquietas (enfermedad de Willis-Ekbom): seguimiento a largo plazo de una serie de pacientes.

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■ The relationship of restless legs syndrome to history of pregnancy-induced hypertension

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J Womens Health (Larchmt) 2016 Apr 1; 25(4): 397–408

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■ Diagnostic accuracy of behavioral, activity, ferritin, and clinical indicators of restless legs syndrome

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■ Brazilian consensus on guidelines for diagnosis and treatment for restless legs syndrome.

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■ Excessively crying infants are more common among children of parents with restless legs syndrome

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MedicalExpress (São Paulo, online), Dec 2015, vol.2, no.6

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■ Restless legs syndrome and pregnancy: a review

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■ The relationship among restless legs syndrome (Willis-Ekbom disease), hypertension, cardiovascular disease, and cerebrovascular disease

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■ Comorbidities, medications and depressive symptoms in patients with restless legs syndrome and migraine

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013000200006&lng=pt&nrm=iso

■ The treatment of restless legs syndrome and periodic limb movement disorder in adults – an updte for 2012: practice parameters with an evidence-based systematic review and meta-analyses: An American Academy of Sleep Medicine Clinical Practice Guideline

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■ Epidemiology of restless legs syndrome

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