Blog - INTERNET MÉDICA

Hemoglobinúria Paroxística Noturna: Casos Clínicos (Paroxysmal Nocturnal Hemoglobinuria: Case Reports)

Por Paulo Leite 20/12/2021

– A hemoglobinúria paroxística noturna é um distúrbio da medula óssea caracterizado por hemólise intravascular e hemoglobinúria. Leucopenia, trombocitopenia, tromboses arteriais e venosas são comuns. Ocorre por uma mutação do gene PIG-A, responsável pela síntese de moléculas que ancoram as proteínas CD59 e CD55 à membrana do eritrócito. A ausência dessas proteínas suscetibiliza os eritrócitos à lise pelo sistema do complemento. O diagnóstico requer citometria de fluxo.

■ Paroxysmal nocturnal hemoglobinuria in the context of a myeloproliferative neoplasm: a case report and review of the literature

Juri Alessandro Giannotta, Bruno Fattizzo, Wilma Barcellini

Front Oncol.2021; vol 11: 756589

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8632248/

■ Hemoglobinúria paroxística noturna: relato de caso clínico com pancitopenia

D R Almeida, L M Cichota, L M Bottega, L V P Silva

Hematology, Transfusion and Cell Therapy 2020, vol 42: S2

http://www.htct.com.br/en-hemoglobinuria-paroxistica-noturna-relato-de-articulo-S2531137920302996

■ Relato de caso: hemoglobinúria paroxística noturna

J F L M da Silva, K M N Reis, B A Gandra et al

Revista Científica FAGOC – Saúde 2020, vol 5 (2)

https://revista.unifagoc.edu.br/index.php/saude/article/view/662/608

■ Treatment of paroxysmal nocturnal hemoglobinuria in pregnancy with eculizumab: a case report

Michael J. Fassett, Adrian L. Hernandez Lopez

Case Rep Womens Health.2021vol 30: e00294

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7903290/

■ Severe hemolysis in a COVID-19 patient with paroxysmal nocturnal hemoglobinuria

Steve Biko Otieno, Alaa Altahan, Fnu Kaweeta et al

Case Rep Hematol.2021; 2021: 6619177

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8285198/

■ COVID-19 infection presenting as paroxysmal nocturnal hemoglobinuria

Adam Hines, Nausheen Hakim, Jacqueline Barrientos

Clin Case Rep.2021vol 9(8): e04636

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8380091/

■ A case report: paroxysmal nocturnal hemoglobinuria and systemic lupus erythmetosus association

Istemi Serin, Aslıhan Bayir, Hasan Goze, Osman Yokus

Int J Hematol Oncol.2021, vol 10(1): IJH3

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8191648/

■ Coombs-positive paroxysmal nocturnal haemoglobinuria

S Kalam, R Beale, D Hughes, et al

Oxf Med Case Report mar 2020

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7104188/

■ Prolonged remission of cancer of unknown primary following initiation of eculizumab therapy for paroxysmal nocturnal hemoglobinuria

Ming Y. Lim, Keith E. Volmar, Nigel S. Key

Case Rep Hematol.2019; 2019: 2587597

https://www.hindawi.com/journals/crihem/2019/2587597/

■ Autosplenectomy in a patient with paroxysmal nocturnal hemoglobinuria (PNH)

Ethan Burns, Kartik Anand, Gonzalo Acosta et al

Case Rep Hematol.2019; 2019: 3146965

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6390241/

■ Hemoglobinuria Paroxística Noturna (Paroxismal Nocturnal Hemoglobinuria)

Arquivos Blog Internet Médica – julho 2018

https://internetmedica.com.br/hemoglobinuria-paroxistica-noturna-online-paroxysmal-nocturnal-hemoglobinuria/

■ Dr Paulo Fernando Leite

Cardiologia/Prevenção Cardiovascular

Consultório: Rua Padre Rolim 815/sala 601 – Belo Horizonte/MG/Brasil

Tel: 33245518

CRMMG: 7026

Email: pfleite1873@gmail.com

Blog Internet Médica – www.internetmedica.com.br

Data: dezembro 2021

Espondiloartropatias & Doença Inflamatória Intestinal (Spondyloarthritis & Inflammatory Bowel Disease)

Por Paulo Leite 20/12/2021

– Artrite psoriásica, espondilite anquilosante e espondiloartropatia indiferenciada são as outras condições incluídas nas espondiloartropatias inflamatórias que compartilham características clínicas e etiológicas comuns.

– As manifestações extra intestinais que afetam a pele, olhos e articulações se desenvolvem em cerca de um quarto dos pacientes com doença inflamatória intestinal (DII) sendo as manifestações osteomusculares as mais comuns, com aproximadamente 5-20% dos indivíduos com DII desenvolvendo artrite periférica e/ou espondilite.

– O envolvimento axial na DII ocorre em qualquer idade, em contraste com a EA idiopática, que afeta homens com menos de 40 anos.

■ Systematic review and meta-analysis of inflammatory bowel disease adverse events with anti-interleukin 17A agents and tumor necrosis factor inhibitor in rheumatic disease and skin psoriasis

Steven L. Truong, Jasmine Chin, David F. L. Liew et al

Rheumatol Ther.2021, vol 8(4): 1603–1616

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8572260/

■ Prevalence of axial spondyloarthritis in patients with inflammatory bowel disease using cross-sectional imaging: a systematic literature review

J Evans, M Sa0sford, S McDonald et al

Their Adv Musculoskelet Dis 2021, vol 13: 1759720X21996973

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7958176/

■ Managing Psoriatic arthritis with inflammatory bowel disease and/or uveitis

A Y T Chia, G W X Ang, A S Y Chan et al

Front Med September 2021

https://www.frontiersin.org/articles/10.3389/fmed.2021.737256/full

■ Inhibition of phosphodiesterease-4 in psoriatic arthritis and inflammatory bowel disease

Andrea Picchianti-Diamanti, Francesca Romana Spinelli, Maria Manuela Rosado et al

Int J Mol Sci.2021, vol 22(5): 2638

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7961737/

■ IBD consideration in spondyloarthritis

C D Jiang, T Raine

Ther Adv Musculoskelet Dis 2020:vol 12: 1759720X20939410

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7350041/

■ Chronic pain in patients with inflammatory bowel disease

Nikul Bakshi, Ailsa L. Hart, Michael C. Lee et al

Pain.2021, vol 162(10): 2466–2471

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8442739/

■ The arthritis conncetion to inflammatory bowel disease (IBD): why has it taken so long to undertand it?

Maedeh Ashrafi, Kristine A Kuhn, Michael H Weisman

RMD Open.2021; vol 7(1): e001558

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8055104/

■ Low incidence of inflammatory bowes disease adverse events in adalimumab clinical trials across nine different diseases

Dirk Elewaut, Jürgen Braun, Jaclyn K. Anderson et al

Arthritis Care Res (Hoboken)2021, vol 73(2): 289–29

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7898340/

■ From bowel inflammatory to the bone and joints: musculoskeketal examination in inflammatory bowel disease (IBD)

S Tavassoli, I Shahabinasab, A Norouzi et al

BMC Musculoskelet Disord 2021, vol 22: 1019

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8645134/

■ Management of patients with inflammatory bowel disease and spondyloarthritis

L Pouillonm P Bossuyt, J Vanderstukken, D Moulin et al

Expert Review of Clinical Pharmacology, Informa Plc, 2017, vol 10 (12): 1363-1374

https://hal.univ-lorraine.fr/hal-01715137/document

■ Doença Inflamatória Intestinal: Diretrizes Médicas (Inflammatory Bowel Disease: Guidelines)

Arquivo Blog Internet Médica – fevereiro 2021

https://internetmedica.com.br/doenca-inflamatoria-intestinal-diretrizes-medicas-inflammatory-bowel-disease-guidelines/

■ Doença inflamatória intestinal: Organizações Médicas (Inflammatory Bowel Disease: Medical Organizations)

Arquivo Blog Internet Médica – julho 2020

https://internetmedica.com.br/doenca-inflamatoria-intestinal-organizacoes-medicas-online-inflammatory-bowel-disease-medical-organizations/

■ Artrite Psosiásiva: Artigos de Revisão (Psoriatic Arthritis: Reviews)