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Síndrome de Mounier-Kuhn Online (Mounier-Kuhn syndrome)

Por Paulo Leite 16/07/2018

¨A síndrome de Mounier-Kuhn ou traqueobroncomegalia é uma doença rara, caracterizada por atrofia ou ausência de fibras elásticas e adelgaçamento da musculatura lisa na traqueia, brônquios principais e de primeira à quarta ordem; consequentemente, as vias aéreas flácidas tornam-se bastante alargadas na inspiração e colapsadas na expiração. Os sintomas podem ser variáveis. A doença é caracterizada clinicamente pela presença de infecções respiratórias de repetição, acúmulo de secreção e tosse inefetiva. Observa-se leve predomínio no sexo masculino, na terceira ou quarta décadas de vida, mas a exata prevalência da doença não é conhecida e são poucos os casos relatados na literatura. Acredita-se que a fraqueza do tecido conjuntivo, associada à inalação de poluentes aéreos e fumaça de cigarro, sejam os principais fatores no desenvolvimento desta síndrome. O tratamento geralmente é de suporte ¨

■ Flexible bronchoscopy and mechanical ventilation in managing Mounier-Kuhn syndrome: a case report

Kaya, Aslihan Gürün et al.

Sao Paulo Med. J., May 2018, vol.136, no.3, p.266-269

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802018000300266&lng=pt&nrm=iso&tlng=en

■ Current concepts in severe adult tracheobronchomalacia: evaluation and treatment

Daniel H. Buitrago, Jennifer L. Wilson, Mihir Parikh et al

J Thorac Dis. 2017 Jan; 9(1): E57–E6

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303067/

■ Mounier-Kuhn syndrome: a case of trachel smooth muscle remodeling

Daniel P. Cook, Ryan J. Adam, Mahmoud H. Abou Alaiwa et al

Clin Case Rep. 2017 Feb; 5(2): 93–96

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290513/

■ Congenital tracheobronchomegaly (Mounieer-Kuhn syndrome) in a woman with human immunodeficiency virus: a case report

Amanda Fletcher, Justin Stowell, Socrates Jamoulis

Cureus. 2017 Apr; 9(4): e1136

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418028/

■ Mounier-Kuhn syndrome in an elderly female with pulmonary fibrosis

P Boglou, N Papanas, A Oikonomou et AL

Case Reports in Medicne 2016, Article ID 8708251, 4 pages

https://www.hindawi.com/journals/crim/2016/8708251/

■ Mounier-Kuhn syndrome: more than just a cough

Christine Azzopardi, Joseph Attard, Edith Vassallo, Reuben Grech

BMJ Case Rep. 2014; 2014: bcr201420615

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166130/

■ Mounier-Kuhn syndrome in an elderly female with pulmonary fibrosis

Panagiotis Boglou, Nikolaos Papanas, Anastasia Oikonomou et al

Case Rep Med. 2016; 2016: 870825

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002455/

■ Traqueobroncomegalia: a propósito de un caso clínico-radiológico

Canales F, Luis et al

Rev. chil. enferm. respir., Jun 2015, vol.31, no.2, p.101-104

https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0717-73482015000200005&lng=es&nrm=iso

■ Mounier-Kuhn syndrome: more than Just a cough

Christine Azzopardi, Joseph Attard, Edith Vassallo, Reuben Grech

BMJ Case Rep. 2014; 2014: bcr201420615

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166130/

■ Mounier-Kuhn syndrome: a rare and often overlooked cause of bronchial dilation and recurrent respiratory tract infections

Kapoor, Shailendra.

bras. pneumol., Jan 2014, vol.40, no.1, p.96-9

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132014000100096&lng=pt&nrm=iso

■ A delayed diagnosis of Mounier-Kuhn syndrome

Caroline Gouder, David Bilocca, Peter Fsadni, Stephen Montefort

BMJ Case Rep. 2014; 2014: bcr2014203674

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054406/

■ Mounier-Kuhn syndrome. Imaging and bronchoscopic findings

K El-Kersh, M Yasin, R Cavallazzi, R L Perez

AJRCCM 2014, vol 190 (1)

https://www.atsjournals.org/doi/full/10.1164/rccm.201307-1306IM

■ Are airways structural abnormalities more frequent in children with recurrent lower respiratory tract infections?

M Santiago-Burruchaga, R Zalacain-Jorge, C Vazquex-Cordero

Respiratory Medicine 2014, vol 108, vol 5:800-805

https://www.resmedjournal.com/article/S0954-6111(14)00089-4/fulltext

■ Mounier-Kuhn syndrome or congenital tracheobronchomegaly: a literature review

E Krustins, Z Kravale, A Buls

Respiratory Medicine 2013, vol 107 (12): 1822-1828

https://www.resmedjournal.com/article/S0954-6111(13)00361-2/fulltext

■ Infección respiratoria causada por Alcaligenes xylosoxidans en un paciente con síndrome de Mounier-Kuhn

Arroyo-Cózar, Marta et al.

Rev. chil. infectol., Oct 2012, vol.29, no.5, p.570-571

https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-10182012000600019&lng=es&nrm=iso

■ Mounier-Kuhn syndrome: the role of bronchiectasis in clinical presentation

Edson Marchiori, Arthur Sousa Sousa, Jr, Gláucia Zanetti, Bruno Hochhegger

Ann Thorac Med. 2012 Jan-Mar; 7(1): 51

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277044/

■ Mounier-Kuhn syndrome: anesthetic experience

D S Ushakumari, N Grewal, M Green

Case Reports in Anesthesiology 2012, Article ID 674918, 2 pages

https://www.hindawi.com/journals/cria/2012/674918/

■ Mounier-Kuhn syndrome

B Celik, S Bilgin, C Yuksel

Texas Heart Inst J 2011,vol 38 (2):: 194-196

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066798/

■ Síndrome de Mounier-Kuhn: achados radiológicos e apresentação clínica

Bastos, Andréa de Lima and Brito, Isabela Lage Alves

Radiol Bras, Jun 2011, vol.44, no.3, p.198-200

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-39842011000300016&lng=pt&nrm=iso

■ Síndroma de Mounier-Kuhn, uma causa rara de infecções respiratórias de repetição

A Marques, M Félix, F Barata et al

Revista Portuguesa de Pneumologia 2007, vol XIII N.5, set-out2007

http://www.elsevier.pt/en/revistas/revista-portuguesa-pneumologia-320/pdf/S2173511507703664/S300/

■ Pulmonary transplantation in Mounier-Kuhn syndrome: a case report

S S Shah, D Karnak, D Mason et al

Journal of Thoracic and Cardiovascular Surgery 2006, vol 131 (3): 757-758

https://www.jtcvs.org/article/S0022-5223(05)01998-7/fulltext

■ Síndrome de Mounier-Kühn

Fortuna, Fabrício Piccoli et al.

bras. pneumol., Abr 2006, vol.32, no.2, p.180-183

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132006000200015&lng=pt&nrm=iso

■ Traqueobroncomegalia (síndrome de Mounier-Kuhn): relato de caso e revisão da literatura

Nóbrega, Bruno Barcelos da et al.

Radiol Bras, Jun 2002, vol.35, no.3, p.187-189

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-39842002000300012&lng=pt&nrm=iso

■ by Dr Paulo Fernando Leite

Cardiologia – Centro Médico Unimed BH

Rua Gonçalves Dias 202

Belo Horizonte/MG/Brasil

31 30033306 / 40204020

CRMMG: 7026

Email: pfleite1873@gmail.com

Diretor da MWS – www.mwsedumed.com.br

Síndrome de Meigs Online (Meigs´s syndrome)

Por Paulo Leite 16/07/2018

¨A síndrome de Meigs é a tríade caracterizada por tumor pélvico benigno, ascite e efusão pleural – ou hidrotórax – concomitantes, associada à cura da doença após a exérese da tumor. Em outras publicações, descreve-se a síndrome de Meigs como a presença de um tumor ovariano benigno em associação com ascite e hidrotórax. Níveis elevados de CA 125 sérico em mulheres pós-menopáusicas com massa anexial sólida, ascite e derrame pleural são muito sugestivos de tumor ovariano maligno. Logo, pacientes com síndrome de Meigs podem apresentar níveis elevados de CA 125.¨

■ Hydrothorax, ascites, and an abdominal mass: not always signsof a malignancy – Three cases of Meigs´s syndrome

Kim E Kortekaas, Harold MP Pelikan

J Radiol Case Rep. 2018 Jan; 12(1): 17–26

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965394/

■ Large twisted ovarian fibroma associated with Meigs´s syndrome, abdominal pain and severe anemia treated by laparoscopic surgery

Antonio Macciò, Clelia Madeddu, Paraskevas Kotsonis et al

BMC Surg. 2014; 14: 38

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074309/

■ A case of Meigs´s syndrome with preceding pericardial effusion in advance of pleural effusion

Kenichi Okuda, Satoshi Noguchi, Osamu Narumoto et al

BMC Pulm Med. 2016; 16: 71

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862177/

■ Pleural effusion in Meigs´s syndrome – transudate or exudate?

R Krenke, M Maskey-Warzechowska, P Korczynski et al

Medicine (Baltimore) 2015, vol 94 (49): e2114

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008483/

■ Postmenopausal Meig´s syndrome in elevated CA-125: a case report

Jung-Woo Park, Jong Woon Bae

J Menopausal Med. 2015 Apr; 21(1): 56–59

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452815/

■ Meigs´s syndrome with elevated CA-125 and HE-4: a case of luteinized fibrothecoma

Jaroslaw Danilos, Wojciech Michał Kwaśniewski, Diana Mazurek et al

Prz Menopauzalny. 2015 Jun; 14(2): 152–154

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498034/

■ Large twisted ovarian fibroma associated with Meig´s syndrome, abdominal pain and severe anemia treated by laparoscopic surgery

A Maccio, C Madeddu, P Kotsonis et al

BMC Surg 2014,vol 14: 38

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074309/

■ Meigs syndrome presenting with axillary vein thrombosis and lymphadenopathy: a case report

Ridhima Iyer, Jason Chow, Mona El-Bahrawy, Philip Savage

J Med Case Rep. 2013; 7: 182

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750274/

■ Tumor estromal esclerosante de ovário associado à síndrome de Meigs e gestação: relato de caso

Gomes Sobrinho, David Barreira et al.

Rev. Bras. Ginecol. Obstet., Jul 2013, vol.35, no.7, p.331-335

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032013000700008&lng=pt&nrm=iso

■ Meigs´s syndrome

D J Quinlan,

JOJC 2012, vol 34 (4): 311

https://www.jogc.com/article/S1701-2163(16)35204-5/abstract

■ Severe edema and elevated CA 125 in a 56-year-old woman

N S Tan, S W Hwang

CMAJ 212, vol184 (6): 671-673

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314038/

■ Meigs´s syndrome with elevated serum CA125: case report and review of the literature

Mongkol Benjapibal, Suthi Sangkarat, Somsak Laiwejpithaya et al

Case Rep Oncol. 2009 Jan-Apr; 2(1): 61–66

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918831/

■ A case of Meigs syndrome mimicking metastatic breast carcinoma

Sophocles Lanitis, Sivahamy Sivakumar, Kasim Behranwala et al

World J Surg Oncol. 2009; 7: 10.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633000/

■ Meigs’ syndrome with elevated CA 125: case report.

Vieira, Sabas Carlos et al.

Sao Paulo Med. J., 2003, vol.121, no.5, p.210-212

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802003000500007&lng=pt&nrm=iso&tlng=en