Blog - INTERNET MÉDICA

Toxoplasmose Online (Toxoplasmosis)

Por Paulo Leite 26/06/2018

¨A toxoplasmose é uma das principais zoonoses mundiais transmitidas por alimentos, principalmente pela ingestão de carne crua ou mal cozida. Seu agente etiológico, Toxoplasma gondii, é um protozoário intracelular que acomete o ser humano e os animais de produção e selvagens; entretanto, seu ciclo sexuado ocorre somente nos felinos, que são seus hospedeiros definitivos. Estes animais liberam oocistos no ambiente por meio de suas fezes, contaminando o solo e a água, e infectando o homem e os animais de produção. A maioria das infecções causadas pelo Toxoplasma é assintomática. Didadicamente, as formas clínicas podem ser assim divididas: infecção primária em imunocompetentes (toxoplasmose ganglionar), toxoplasmose em pacientes imunocomprometidos, toxoplasmose congênita e coriorretinite isolada (toxoplasmose ocular. A toxoplasmose congênita pode-se apresentar com formas graves ou com sequelas graves tardias, mesmo em crianças assintomáticas ao nascimento. O diagnóstico oportuno da infecção permite o tratamento adequado da gestante, capaz de reduzir a gravidade das sequelas da toxoplasmose no feto. A prevenção da toxoplasmose congênita é de fundamental importância para um melhor controle da infecção evitando as graves seqüelas que podem ocorrer no feto e no recém-nascido (RN). Estima-se que 90% das mulheres que adquirem toxoplasmose durante a gestação são assintomáticas, reforçando a importância da realização de testes sorológicos para confirmação da infecção. Os medicamentos utilizados no tratamento da toxoplasmose são sulfadiazina, sulfametoxazol, pirimetamina, espiramicina e clindamicina. O ácido folínico é adicionados aos esquemas que contenham a pirimetamina devio à mielotoxicidade¨

■ Symptomatic acute toxoplasmosis in returning travelers

A F Henao-Martínez, C Franco-Paredes, A G Palestine, J G Montoya

Open Forum Infectious Diseases 2018, vol 5 (4)

https://academic.oup.com/ofid/article/5/4/ofy058/4925380

■ The association of latent toxoplasmosis and level of serum testosterone in humans

Zouei N, Shojaee S, Mohebali M, Keshavarz H.

BMC Res Notes. 2018 Jun 8;11(1):365

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994116/

■ Sucessful treatment of cerebral toxoplasmosis using pyrimethamine oral solution compounded from inexpensive bulk powder

H A Hodgson, T Sim, H Gonzalez et AL

Open Forum Infectious Diseases 2018, vol 5 (4)

https://academic.oup.com/ofid/article/5/4/ofy055/4976000

■ Avaliação da técnica de ELISA para pesquisa de IgG anti-Toxoplasma gondiiem exsudatos de carnes de sol.

Marciano, Maria Aparecida Moraes, Andrade Junior, Heitor Franco de and Meireles, Luciana Regina

Braz. J. Food Technol., 2018, vol.21

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1981-67232018000100423&lng=en&nrm=iso

■ Toxoplasmosis congénita: Diagnóstico serológico, RPC, aislamiento y caracterización molecular de Toxoplasma gondii.

Carral, Liliana et al.

Rev. chil. infectol., 2018, vol.35, no.1, p.36-40

https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-10182018000100036&lng=es&nrm=iso

■ Diagnosis, treatment, and prevention of congenital toxoplasmosis in the United States

Y A Maldonado, J S Read – Committee on infectious Diseases

Pediatrics 2017, vol 139 (2)

http://pediatrics.aappublications.org/content/139/2/e20163860

■ Recent developments in the diagnosis and treatment of Ocular Toxoplasmosis

C Ozgonul, C G Besirli

Ophthalmic Research 2017, vol 57 (1)

https://www.karger.com/Article/FullText/449169

■ Neurophysiological changes induced by chronic toxoplasma gondii infection

Ellen Tedford, Glenn McConkey

Pathogens. 2017 Jun; 6(2): 19

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488653/

■ Congenital toxoplasmosis: a plea for a neglecte disease

MWallon, F Peyron

Pathogens 2018, vol 7 (1): 25

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874751/

■ Disseminated toxoplasmosis in a patient with advanced acquired immunodeficiency syndrome

Pastorello RG, Costa ADCL, Sawamura MVY, Nicodemo AC, Duarte-Neto AN.

Case Rep. 2018 Mar 16;8(1):e2018012

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861962/

■ Cerebral toxoplasmosis diagnosed by nested-polymerase chain reaction in a patient with rheumatoid arthritis

Matsuura J, Fujii A, Mizuta I, Norose K, Mizuno T.

Intern Med. 2018 May 15;57(10):1463-1468

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995717/

■ Successful treatment of pulmonary and cerebral toxoplasmosis associated with pneumocystic pneumonia in a HIV patient

Rey MF, Mary C, Sanguinetti D, Ranque S, Bartoli C, L’Ollivier C.

Diseases. 2017 Dec 18;5(4). pii: E35

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750546/

■ IgG avidity test in congenital toxoplasmosis diagnoses in newborns

Zulmirene Cardoso Fonseca, Isolina Maria Xavier Rodrigues et AL

Pathogens. 2017 Jun; 6(2): 26

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488660/

■ Alterações auditivas em crianças expostas à toxoplasmose durante a gestação.

Leite Filho, Carlos Alberto et al.

Rev. CEFAC, Jun 2017, vol.19, no.3, p.330-339

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-18462017000300330&lng=en&nrm=iso

■ Is Toxoplasma gondii a trigger of bipolar disorder?

Claudia Del Grande, Luca Galli, Elisa Schiavi, Liliana Dell’Osso, Fabrizio Bruschi

Pathogens. 2017 Mar; 6(1): 3.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371891/

■ Drugs in development for toxoplasmosis: advances, challenges, and current status

P Holland Alday, Joseph Stone Doggett

Drug Des Devel Ther. 2017; 11: 273–293

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5279849/

■ Investigating the determinants of Toxoplasma gondii prevalence in meat: a systematic review and meta-regression

Simone Belluco, Marzia Mancin, Daniele Conficoni, et al

PLoS One. 2016; 11(4): e0153856

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833317/

■ Understanding toxoplasmosis in the United States through ¨large data¨ analyses

Joseph Lykins, Kanix Wang, Kelsey Wheeler et al

Clin Infect Dis. 2016 Aug 15; 63(4): 468–475

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967610/

■ Toxoplasmose gestacional: uma revisão

D L Walcher, B Comparsi, D Pedroso

Revista Brasileira de Análise Clinica 2016

http://www.rbac.org.br/artigos/toxoplasmose-gestacional-uma-revisao/

■ Cerebral toxoplasmosis

R Ozaras, B Karaismailoglu, A Vatan et al

QJM: An International Journal of Medicine 2016, vol 109 (7): 491-492

https://academic.oup.com/qjmed/article/109/7/491/1752932/Cerebral-toxoplasmosis

■ Evaluation of Pregnant and Postpartum Women’s Knowledge about Toxoplasmosis in Rio Grande – RS, Brazil.

Lehmann, Lis Maurente, Santos, Paula Costa and Scaini, Carlos James

Rev. Bras. Ginecol. Obstet., Nov 2016, vol.38, no.11, p.538-544

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032016001100538&lng=en&nrm=iso&tlng=en

■ Avaliação do método Western Blotting para diagnóstico de toxoplasmose congênita

Capobiango, Jaqueline Dario et al

Pediatr. (Rio J.), Dec 2016, vol.92, no.6, p.616-623

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572016000700616&lng=en&nrm=iso&tlng=pt

■ Combined branch retinal vein and artery occlusion in toxoplasmosis.

Aggio, Fabio Bom et al.

Arq. Bras. Oftalmol., June 2016, vol.79, no.3, p.189-191

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492016000300189&lng=en&nrm=iso&tlng=en

■ Toxoplasmose adquirida na gestação e toxoplasmose congênita: uma abordagem prática na notificação da doença.

Capobiango, Jaqueline Dario et al.

Epidemiol. Serv. Saúde, Mar 2016, vol.25, no.1, p.187-194

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2237-96222016000100187&lng=en&nrm=iso

■ Fatores associados ao conhecimento sobre a toxoplasmose entre gestantes atendidas na rede pública de saúde do município de Niterói, Rio de Janeiro, 2013-2015

Moura, Fernanda Loureiro de et al.

Epidemiol. Serv. Saúde, Set 2016, vol.25, no.3, p.655-661

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2237-96222016000300655&lng=en&nrm=iso

■ Human toxoplasmosis outbreaks and the agent infecting form. Findings from a systematic review

Meireles, Luciana Regina et al

Rev. Inst. Med. trop. S. Paulo, Oct 2015, vol.57, no.5, p.369-376

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652015000500369&lng=en&nrm=iso&tlng=en

■ Epidemiology of and diagnostic strategies for toxoplasmosis

Florence Robert-Gangneux, Marie-Laure Dardé

Clin Microbiol Rev. 2012 Apr; 25(2): 264–296

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346298/

■ How to diagnose & treat ocular toxoplasmosis

M Soheilian, a ramezani, R Soheilian

Review of Ophthalmology february 2017

https://www.reviewofophthalmology.com/article/how-to-diagnose-treat-ocular-toxoplasmosis

■ by Dr Paulo Fernando Leite

Cardiologia – Centro Médico Unimed BH

Rua Gonçalves Dias 202

Belo Horizonte/MG/Brasil

31 30033306 / 40204020

Diretor da MedWebServiços – http://mwsedumed.com.br/

CRMMG: 7026

Email: pfleite1873@gmail.com

Oftalmologia: Organizações Médicas Online (Ophthalmolgy online)

Por Paulo Leite 24/06/2018

Acesse online as principais organizações médicas online no campo da Oftalmologia:

■ American Academy of Ophthalmology

https://www.aao.org/

■ American Glaucoma Society

http://www.americanglaucomasociety.net/

■ American Ophthalmological Society

https://www.aosonline.org/

■ American Society of Cataract and Refractive Surgery

http://www.ascrs.org/

■ American Society of Corneal Refractive Surgeons

http://www.escrs.org/

■ American Society of Retina Specialists

https://www.asrs.org/

■ American Uveitis Society

http://www.uveitissociety.org/

■ Asia-Pacific Glaucoma Society

https://www.apglaucomasociety.org/

■ Belgian Retina Society

http://www.ophthalmologia.be/

■ Associação Brasileira de Catarata e Cirurgia Refrativa

http://www.brascrs.com.br/

■ Australian Society of Ophthalmologists

http://www.asoeye.org/

■ American Society of Ophthalmic Plastic and Reconstructive Surgery

https://www.asoprs.org/

■ British Society for Refractive Surgery

http://www.bsrs.co.uk/

■ British OculoPlastic Surgery Society

https://www.bopss.co.uk/

■ Canadian Keratoconus Foundation

http://keratoconuscanada.org/

■ Canadian Ophthalmological Society

http://www.cos-sco.ca/

■ Canadian Retina Society

https://www.crssrc.ca/

■ Canadian Uveitis Society

http://canadianuveitissociety.com/

■ Centro Brasileiro de Estrabismo

■ Conselho Brasileiro de Oftalmologia

http://www.cbo.com.br/

■ Contact Lens Society of America

https://www.clsa.info/

■ Contact Lens Association of Ophthalmologists

http://www.clao.org/

■ Cornea & Contact Lens Society of Australia

https://www.cclsa.org.au/

■ Cornea & Contact Lens Society

http://www.contactlens.org.nz/

■ Corneal Research Foundation

http://www.cornea.org/

■ Corneal Society

http://www.corneasociety.org/

■ European Contact Lens Society of Ophthalmologists

https://www.eclso.eu/

■ European Glaucoma Society

https://www.eugs.org/eng/default.asp

■ European Neuro-Ophthalmology Society

https://www.eunosweb.eu/

■ Euretina

http://www.euretina.org/

■ European Society of Cataract and Refractive Surgeons

http://www.escrs.org/

■ European Society of Ocular and Surface Disease Specialists

http://www.eucornea.org/

■ European Society of Ophthalmology

http://soevision.org/

■ European Vitreo Retinal Society

http://www.evrs.eu/

■ International Council of Ophthalmolgy

http://www.icoph.org/

■ International Glaucoma Association

https://www.glaucoma-association.com/

■ International Keratoconus Academy

https://www.keratoconusacademy.com/

■ International Ocular Inflammation Society

http://iois.memberlodge.org/

■ International Uveitis Study Group

https://www.iusg.net/

■ International Ophthalmology Portal

https://iop.vision/

■ International Society for Genetic Eye Diseases & Retinoblastoma

https://isgedr.com/

■ International Society of Ocular Oncology

http://www.isoo.org/

■ International Society of Ocular Trauma

https://isotonline.org/

■ International Society of Refractive Surgery

https://www.isrs.org/

■ International Thyroid Eye Disease Society

http://thyroideyedisease.org/

■ International Uveitis Study Group

https://www.iusg.net/

■ Irish College of Ophtalmologists

http://www.eyedoctors.ie/

■ Japanese Society of Cataract and Refractive Surgery

https://www.jscrs.org/english/index_en.html

■ Keratoconus.net

http://www.keratocone.net/

■ National Glaucoma Society

https://www.nationalglaucomasociety.org/

■ National Keratoconus Foundation

https://www.nkcf.org/

■ Ophthalmological Society of South Africa

https://www.ossa.co.za/

■ Pan-American Association of Ophthalmology

https://www.paao.org/

■ Pancornea- Sociedad Panamericana de Cornea

http://pancornea.org/

■ Royal College of Ophthalmogists

https://www.rcophth.ac.uk/

■ Royal Australian and New Zealand College of Ophthalmologists

https://ranzco.edu/

■ National Eye Institute

https://nei.nih.gov/

■ New York State Ophythalmolical Society

http://www.nysos.com/

■ North American Neuro-Ophthalmology Society

https://www.nanosweb.org/home.cfm

■ Retina Society

http://www.retinasociety.org/

■ Royal College of Ophthlamology

https://www.rcophth.ac.uk/

■ Sociedad Argentina de Oftalmologia

https://www.sao.org.ar/

■ Sociedad Argentina de Oftalmologia Infantil

http://saoi.org.ar/

■ Sociedad Española de Cirurgia Plástica Ocular y Orbitaria

https://secpoo.com/

■ Sociedad Española de Oftalmologia

https://www.oftalmoseo.com/

■ Sociedad Mexicana de Oftalmologia

https://www.smo.org.mx/index2.php

■ Sociedade Brasileira de Administração em Oftalmologia

http://www.sbao.com.br/

■ Sociedade Brasileira de Cirurgia Plástica Ocular

http://www.sbcpo.org.br/

■ Sociedade Brasileira de Glaucoma

https://www.sbglaucoma.org.br/

■ Sociedade Brasileira de Lentes de Contato, Córnea e Refratometria

http://soblec.com.br/

■ Sociedade Brasileira de Oftalmologia

http://www.sboportal.org.br/

■ Sociedade Brasileira de Oftalmologia Pediátrica

http://www.sbop.com.br/

■ Sociedade Brasileira de Oncologia Oftalmológica

http://www.sboo.com.br/

■ Sociedade Brasileira de Retina e Vítreo

https://www.sbrv.org.br/

■ Sociedade Brasileira de Uveítes

http://www.uveitesbrasil.com.br/

■ Sociedade Brasileira de Visão Subnormal

http://www.visaosubnormal.org.br/

■ Sociedade Portuguesa de Oftalmologia

http://www.spoftalmologia.pt/

■ Società Oftalmologia Italiana

http://www.soiweb.com/

■ Société Française d´Ophtalmologie

http://www.sfo.asso.fr/

■ The Association for Research in Vision and Ophthalmology

https://www.arvo.org/

■ The Macula Society

http://www.maculasociety.org/

■ United Kingdom & Ireland Society of Cataract & Refractive Surgeons

https://www.ukiscrs.org.uk/