Blog - INTERNET MÉDICA

Síndrome de Reiter Online (Reiter Syndrome)

Por Paulo Leite 15/10/2018

¨A artrite reativa, antes chamada de síndrome de Reiter, é condição rara, de distribuição universal, caracterizada por uretrite, conjuntivite (ou, mais raramente, uveíte), lesões mucocutâneas e artrite asséptica. Acomete preferencialmente indivíduos adultos do sexo masculino. Caracteriza-se por poliartrite periférica soronegativa, com duração mais longa do que um mês, manifestando-se geralmente após quadro infeccioso disentérico ou urogenital. Acometimentos mucocutâneo, ungueal e ocular são comuns. A síndrome de Reiter faz parte de um grupo de doenças denominadas espondiloartropatias soronegativas, que exibem predisposição hereditária associada à presença do antígeno do complexo de histocompatibilidade maior (HLA-B27) e têm em comum graus variáveis de manifestações artrocutâneas e oculares. Sua etiopatogenia não está completamente compreendida, porém a consistente associação com o HLA-B27. Há duas formas epidemiológicas distintas: uma endêmica ou venérea, iniciada por uretrite inespecífica, cujo agente infeccioso mais importante é a Chlamydia trachomatis, sendo também implicados o Ureaplasma e o Mycoplasma como possíveis agentes; outra epidêmica ou pós-disentérica, na qual se inclui o paciente em questão, em seguimento após uma infecção intestinal por microorganismos Gram negativos chamados artritogênicos, incluindo os gêneros Shigella, Salmonella, Yersinia, Campylobacter e Clostridium. Não há cura para a síndrome de Reiter. Aproximadamente dois terços dos pacientes apresentam remissão do quadro em seis meses. Recorrências são freqüentes, com 40% dos pacientes apresentando um segundo episódio, como observado no paciente em questão. Na fase aguda, repouso e antiinflamatório não hormonal podem ser úteis.¨

■ Case: Bacillus Calmette-Guerin (BCG)-induced Reiter syndrome with an attempt at repeat BCG induction

D C Cheung, A L Millman, R J Hamilton

Can Urol Assoc J 2018, vol 12 (1): E37-E39

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783707/

■ Seronegative spondylarthritis

A Jagpal, S S Vinod, S L Bridges Jr

Orthopedic Suergery Clerkship Springer, Cham 2017: 729-734

https://link.springer.com/chapter/10.1007/978-3-319-52567-9_150

■ Circinate balanitis as the presenting symptoms of sexually-acquired reactive arthritis: a case report

R Carney, T Buhary, L S The, S Gayed

Br J Gen Pract 2015, vol 65 (634): 266-267

https://bjgp.org/content/65/634/266

■ Syphilis associated with paretic neurosyphilis mimicking Reiter’s syndrome in HIV-infected patients.

Bastos, Thales Costa et al.

An. Bras. Dermatol., June 2015, vol.90, no.3, suppl.1, p.212-215

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962015000700212&lng=pt&nrm=iso

■ A case of reactive arthritis: a great masquerader

C M Ngaruiya, I B K Martin

The American Journal of Emergency Medicine 2013, vol 31 (1): 226.e5-266.e7

https://www.ajemjournal.com/article/S0735-6757(12)00183-0/fulltext

■ Bilateral multifocal posterior pole lesions in Reiter syndrome

A M Mansour, M O Jaroudi, W A medawaar, Z A Tabbarah

BMJ Case Rep 2013, 2013: cr2013009253

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645110/

■ Reactive arthritis due to Shigella infection after a visit to Egypt: a late complication of an intestinasl infection

Case Reports in Gastrointestinal Medicine 2012, Article ID 972517, 3 pages

https://www.hindawi.com/journals/crigm/2012/972517/

■ Treating reactive arthritis: insights for the clinician

J D Carter

Ther Adv Musculoskelet Dis 2010, vol 2 (1): 45-54

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383466/

■ The epidemiology of infectious gastroenteritis related reactive arthtritis in US military personnel: a case-control study

J A Curry, M S Riddle, R P Gormley et al

BMC Infectious Diseases 2010, vol 10: 266

https://bmcinfectdis.biomedcentral.com/articles/10.1186/1471-2334-10-266

■ Keratoderma blenorrhagicum in a patient with Reiter syndrome

V Dimmitroval, V Valtchev, I Yordanooval et al

Journal of IMAB – Annual Proceeding (Scientific Papers) 2008, vol 14

https://www.journal-imab-bg.org/statii-08/vol08_1_68-71str.pdf

■ When is arthritis reactive

S S Hamdulay, S J Glynne, A Keat

Postgrad Med J 2006, vol 82 (969): 446-453

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2563769/

■ Spondyloarthropathies

R K Kataria, L H Brent

Am Fam Physician 2004, vol 69 (12): 2853-2860

https://www.aafp.org/afp/2004/0615/p2853.html

■ Reiter syndrome – a case report and review of literature

C O Alebiosu, T Raimi, A I Basru et al

Afr Health Sci 2004, vol 4 (2): 136-138

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2141619/

■ Reiter´s syndrome as a manifestation of an immune reconstitution syndrome in an HIV-infected patient: successful treatment with doxycycline

S Neumann, F Kreth, S Schubert et al

Clinical Infectious Diseases, 2003, vol 36 (12): 1628-1629

https://academic.oup.com/cid/article/36/12/1628/299283

■ Síndrome de Reiter: relato de caso

Sousa, Ana Elisabete Simões de et al.

An. Bras. Dermatol., Jun 2003, vol.78, no.3, p.323-33

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962003000300009&lng=pt&nrm=iso

■ Reiter’s Syndrome associated with the acquired immunodeficiency syndrome: a case report

Malta, J.B.N.S. et al.

Braz J Infect Dis, Feb 2002, vol.6, no.1, p.40-44

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000100006&lng=pt&nrm=iso

by Dr Paulo Fernando Leite

■ Cardiologia/Prevenção Cardiovascular

■ Estratificação de Risco Cardiovascular

Av Contorno 8351 – Conj 01

Belo Horizonte/MG/Brasil

Tel: 31 32919216 2917003 3357229

(- consulta particular –)

CRMMG: 7026

Email: pfleite1873@gmail.com

Vitiligo Online (Vitiligo)

Por Paulo Leite 14/10/2018

¨O vitiligo se caracteriza por manchas acrômicas relacionadas à perda de melanócitos da epiderme e folículo piloso, em qualquer área da pele, que não têm melanócitos. Incide em qualquer idade, em ambos os sexos e acomete até 2% da população em algumas regiões. Vitiligo é um transtorno de pigmentação freqüente na população mundial. Alguns fatores precipitantes para essa doença são: estresse físico e emocional, traumas mecânicos e substâncias químicas, como derivados do fenol. Doenças auto-imunes, principalmente as tireoidianas, podem estar associadas ao vitiligo. O vitiligo é dermatose de difícil tratamento e de significativo impacto psicossocial. Seu tratamento ainda oferece resultados limitados em alguns pacientes. Novas terapias têm sido propostas, como o uso de imunomoduladores tópicos, aliadas àquelas já consolidadas, como os psoralenos e os corticosteróides; o sucesso terapêutico, entretanto, está estritamente relacionado à qualidade da relação médico/paciente. Nos casos de vitiligo estável clinicamente, o transplante de melanócitos torna se uma opção terapêutica, sendo a técnica de enxertos autólogos por punch empregada com boa resposta na repigmentação. ¨

■ Clinical and molecular aspects of vitiligo treatments

Anuradha Bishnoi, Davinder Parsad

Int J Mol Sci. 2018 May; 19(5): 1509

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983813/

■ Vitiligo: patients stories, self-esteem, and the psychological burden of disease

P.E. Grimes, M.M. Miller

Int J Womens Dermatol. 2018 Mar; 4(1): 32–37

www.ncbi.nlm.nih.gov/pmc/articles/PMC5986114/

■ A case series pilot study on the combination of 5-aminolevulinic acid and photodynamic therapy (ALA-PDT) for treatment of vitiligo.

Zhang, YunJie et al.

An. Bras. Dermatol., Aug 2018, vol.93, no.4, p.539-545

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962018000400008&lng=en&nrm=iso

■ Macrophage migration inhibitory factor as an incriminating agent in vitiligo

Farag, Azza Gaber Antar et al.

An. Bras. Dermatol., Mar 2018, vol.93, no.2, p.191-196

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S036

05962018000200191&lng=en&nrm=iso

■ Vitiligo appearing after oral isotretinoin therapy for acne

A A Kokandi

Case Reports in Dermatological Medicine 2018, Article ID 3697260, 3 pages

https://www.hindawi.com/journals/cridm/2018/3697260/

■ Vitiligo patients show significant up-regulation of aryl hydrocarbon receptor transcription factor

Behfarjam, Farinaze and Jadali, Zohreh

An. Bras. Dermatol., Mar 2018, vol.93, no.2, p.302-303

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962018000200302&lng=en&nrm=iso

■ A study of the association of glutathione S-transferase M1/T1 polymorphisms with susceptibility to vitiligo in Egyptian patients

Aly, Dalia Gamal et al.

An. Bras. Dermatol., Feb 2018, vol.93, no.1, p.54-58

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962018000100054&lng=en&nrm=iso

■ Phototherapy for vitiligo: a systematic review and meta-analysis

Jung Min Bae, Han Mi Jung, Bo Young Hong et al

JAMA Dermatol. 2017 Jul; 153(7): 666–674

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817459/

■ Advances in vitiligo: an update on medical and surgical treatments

Alexander B. Dillon, Andrew Sideris, Ali Hadi, Nada Elbuluk

J Clin Aesthet Dermatol. 2017 Jan; 10(1): 15–28

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300730/

■ Vitiligo pathogenesis and emerging treatments

Mehdi Rashighi, John E. Harris

Dermatol Clin. 2017 Apr; 35(2): 257–265

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362109/

■ Adult onset vitiligo: multivariate analysis suggest the need for a thyroid screening

Lazzeri, R. Colucci, A. Cammi, F. Dragoni, S. Moretti

Biomed Res Int. 2016; 2016: 806576

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055927/

■ Anemia perniciosa en una paciente con artritis reumatoide y vitiligo

Rivas-de Noriega, JP, Ontañon-Zurita, D and Turrent-Carriles, A

Med. interna Méx., Ago 2017, vol.33, no.4, p.522-525

http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0186-48662017000400522&lng=es&nrm=iso

■ Prevalence and clinical characteristics of itch in vitiligo and its clinical significance

Vasanop Vachiramon, Woranit Onprasert, Sarawin Harnchoowong, Kumutnart Chanprapaph

Biomed Res Int. 2017; 2017: 5617838

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554571/

■ Vitiligo and autoimmune thyroid disorders

Enke Baldini, Teresa Odorisio, Salvatore Sorrenti et al

Front Endocrinol (Lausanne) 2017; 8: 29

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663726/

■ Optimizing suction blister epidermal graft technique in the surgical treatment of vitiligo

Dellatorre, Gerson, Bertolini, Wagner and Castro, Caio Cesar Silva de

An. Bras. Dermatol., Dec 2017, vol.92, no.6, p.888-890

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962017000600888&lng=en&nrm=iso

■ Insight into natural history of congenital vitiligo: a case report of a 23-year-old with stable congenital vitiligo

C Casey, S E Weis

Case Reports in Dermatological Medicine 2017, Article ID 5172140, 3 pages

https://www.hindawi.com/journals/cridm/2017/5172140/

■ Chemical-induced vitiligo

John E. Harris

Dermatol Clin. 2017 Apr; 35(2): 151–161

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362111/

■ Prepubertal and postpubertal vitiligo: a multivariate comparative study in 375 patients

Khurrum, Huma and AlGhamdi, Khalid M

An. Bras. Dermatol., Dec 2017, vol.92, no.6, p.811-815

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962017000600811&lng=en&nrm=iso

■ Evaluation of treatment response to autologous transplantation of noncultured melanocyte/keratinocyte cell suspension in patients with stable vitiligo

Ramos, Mariana Gontijo, Ramos, Daniel Gontijo and Ramos, Camila Gontijo

An. Bras. Dermatol., June 2017, vol.92, no.3, p.312-318

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962017000300312&lng=en&nrm=iso

■ Vitiligo blood transcriptomics provides new insigts into disease mechanisms and identifies potential novel therapeutic targets

Rama Dey-Rao, Animesh A. Sinha

BMC Genomics. 2017; 18: 109

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5273810/

■ Trends in regenerative medicine: repigmentation in vitiligo through melanocyte stem cell mobilization

Stanca A. Birlea, Gertrude-E. Costin, Dennis R. Roop, David A. Norris

Med Res Rev. 2017 Jul; 37(4): 907–93

https://www.ncbi.nlm.nih.gov/pmc/ticles/PMC5466503/

■ Increased risk of metabolic syndrome in patients with vitiligo

Hatice Ataş, Müzeyyen Gönül

Balkan Med J. 2017 May; 34(3): 219–225.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450861/

■ Knowledge, beliefs, and perceptions of Turkish vitiligo patients regarding their condition

Topal, Ilteris Oguz et al.

An. Bras. Dermatol., Dec 2016, vol.91, no.6, p.770-775

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962016000600770&lng=en&nrm=iso

■ Understanding mechanisms of autoimmunity through translational research in vitiligo

James P Strassner, John E Harris

Curr Opin Immunol. 2016 Dec; 43: 81–88

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292941/

■ Nail abnormalities in patients with vitiligo

Topal, Ilteris Oguz et al.

An. Bras. Dermatol., Aug 2016, vol.91, no.4, p.442-445

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962016000400442&lng=en&nrm=iso

■ Effectiveness and safety of topical tacrolimus monotherapy for repigmentation in vitiligo: a comprehensive literature review.

Sisti, Andrea, Sisti, Giovanni and Oranges, Carlo Maria

An. Bras. Dermatol., Apr 2016, vol.91, no.2, p.187-195

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962016000200187&lng=en&nrm=iso

■ Understanding autoimmunity of vitiligo and alopecia areata

Jillian F. Rork, Mehdi Rashighi, John E. Harris

Curr Opin Pediatr. 2016 Aug; 28(4): 463–46

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957563/

■ Immunological parameters associated with vitiligo treatment: a literature review based on clinical studies

A C G Abreu, G G Duarte, J Y P Miranda, D G Ramos et al

Autoimmune Disease 2015, Article ID 196537, 5 pages

https://www.hindawi.com/journals/ad/2015/196537/

■ Translation, cross-cultural adaptation and validation of the vitiligo-specifi c health-related quality of life instrument (VitiQoL) into Brazilian Portuguese.

Boza, Juliana Catucci et al.

An. bras. dermatol., June 2015, vol.90, no.3, p.358-362

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962015000300358&lng=en&nrm=iso

■ Oxidative stress and immune system in vitiligo and thryroid diseases

Roberta Colucci, Federica Dragoni, Silvia Moretti

Oxid Med Cell Longev. 2015; 2015: 631927

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370195/

■ Epidermal curettage technique (ECT) for tissue harvest from the donor area for melanocyte autologous grafting in cases of vitiligo

Machado Filho, Carlos D’ Apparecida Santos and Timoner, Fabio Roismann

An. bras. dermatol., July 2014, vol.89, no.4, p.681-683

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962014000400681&lng=en&nrm=iso

■ Survey and online discussion groups to develop a patient-rated outcome measure on acceptability of treatment response in vitiligo

Selina K Tour, Kim S Thomas, Dawn-Marie Walker et al

BMC Dermatol. 2014; 14: 10

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075774/

■ Vitiligo – Part 1.

Tarlé, Roberto Gomes et al.

An. Bras. Dermatol., June 2014, vol.89, no.3, p.461-470

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962014000300461&lng=en&nrm=iso

■ Vitiligo – Part 2 – classification, histopathology and treatment.

Faria, Adriane Reichert et al.

An. bras. dermatol., Sept 2014, vol.89, no.5, p.784-790

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962014000500784&lng=en&nrm=iso

■ Concise review of recent studies in vitiligo

Mohamed Allam, Hassan Riad

Qatar Med J. 2013; 2013(2): 1–19

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080492/

■ Non-cultured melanocyte/keratinocyte transplantation for the treatment of stable vitiligo on the face: report of two cases

Ramos, Mariana Gontijo et al.

An. bras. dermatol., Oct 2013, vol.88, no.5, p.811-813

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962013000500811&lng=en&nrm=iso

■ Surgical intervations for vitiligo: na evidence-based review

S V Mulekar, P Isedeh,

British Journal of Dermatology 2013, vol 169 (3): 57-66

https://onlinelibrary.wiley.com/doi/10.1111/bjd.12532

■ Guidelines for the management of vitiligo: the European Dermatologu Forum consensus

A Taieb, A Alomar, M Böhm et AL

British Journal of Dermatology 2013, vol 168 (1): 5-19

https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2133.2012.11197.x

■ Clinical epidemiological profile of vitiligo in children and adolescents

Marinho, Flauberto de Sousa, Cirino, Pablo Vitoriano and Fernandes, Nurimar C.

An. bras. dermatol., Dec 2013, vol.88, no.6, p.1026-1028

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962013000601026&lng=en&nrm=iso&tlng=en

■ VIEWPOIN – Vitiligo and alopecia areata: Apples and oragnes?

John E. Harris

Exp Dermatol. 2013 Dec; 22(12): 10.1111/exd.1226

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867815/

■ Action of topical mometasone on the pigmented halos of micrografting in patients with vitiligo

Saldanha, Karine Dantas Diógenes, Machado Filho, Carlos D’Apparecida Santos and Paschoal, Francisco Macedo

An. Bras. Dermatol., Oct 2012, vol.87, no.5, p.685-69

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962012000500002&lng=en&nrm=iso&tlng=en

■ Pomada de tacrolimo 0,1% no tratamento de vitiligo: série de casos.

Tamler, Carla et al.

An. Bras. Dermatol., Fev 2011, vol.86, no.1, p.169-172

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962011000100034&lng=en&nrm=iso

■ Vitiligo y terapia con inmunoglobulina intravenosa: a propósito de un paciente con síndrome de Sjögren

Badilla P, Alejandro and Díaz G, Carolina

Rev. méd. Chile, Abr 2011, vol.139, no.4, p.484-48

https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000400011&lng=es&nrm=iso

■ Perfil epidemiológico dos pacientes com vitiligo e sua associação com doenças da tireóide

Nunes, Daniel Holthausen and Esser, Ligia Maria Hademann

An. Bras. Dermatol., Abr 2011, vol.86, no.2, p.241-248

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962011000200006&lng=en&nrm=iso

■ Vitiligo is na independent favourable prognosis factor in stage III and IV metastatic melanoma patients: results from a single-institution hospital-based observational cohort study

P Quaglino, F Marenco, S Osella-Abate et AL

Annals of Oncology 2010, vol 21 (2): 409-414

https://academic.oup.com/annonc/article/21/2/409/326023

■ Factores psicobiológicos en vitiligo infantil: Posible rol en su génesis e impacto en la calidad de vida.

Schwartz, Rodrigo, Sepúlveda, Juan Enrique and Quintana, Teresa

Rev. méd. Chile, Ene 2009, vol.137, no.1, p.53-62

https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000100008&lng=es&nrm=iso

■ Guideline for the diagnosis and management of vitiligo

D J Gawkrodger, A D Ormerod L Shaw et al

British Journal of Dermatology 2008, vol 159 (5): 1051-1076

https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2133.2008.08881.x

by Dr Paulo Fernando Leite