Blog - INTERNET MÉDICA

Síndrome de Melkersson-Rosenthal Online (Melkersson-Rosenthal Syndrome)

Por Paulo Leite 25/11/2018

¨A síndrome de Melkersson-Rosenthal (SMR) caracteriza-se por edema orofacial, paralisia facial recorrente e língua plicada. A tríade completa é incomum, com freqüência variando de 8 a 25%, sendo que a apresentação mais comum é a presença de somente um sintoma. A queixa mais freqüente é o edema facial e/ou no lábio. As formas oligossintomáticas constituem a maior porcentagem dos casos, destacando-se a queilite granulomatosa ou de Miesher como a forma clínica predominante. É uma síndrome rara e multidisciplinar com incidência de 1:1250 e patotênese desconhecida. Episódios recorrentes de erisipela, herpes simplex ou furúnculo do lábio superior são diagnósticos errôneos comuns. Os pacientes freqüentemente sofrem com o progresso crônico e espasmódico da doença. A histopatologia tipicamente demonstra uma queilite granulomatosa não caseosa. Terapeuticamente uma terapia tópica com esteroides intralesionais ou triancinolona pode ser tentada. No caso de falta de sucesso, pode-se administrar uma terapia com clofazimina, sulfonamidas, ácido acetilsalicílico, cloroquina, dapsona ou esteróides sistêmicos. Para a maioria das opções terapêuticas, os resultados clínicos alcançados são insatisfatórios. Para os lábios inchados e persistentes, uma terapia cirúrgica ou de radiação tem sido discutida.¨

■ Melkersson-Rosenthal syndrome

J M Placke, M Moelleken, J Dissemond

QJM: An International Journal of Medicine 2018, vol 111 (3)

https://academic.oup.com/qjmed/article/111/3/199/4568571

■ Melkersson-Rosenthal syndrome still a mystery: a case report and suggested guideline investigations

M Alsabbagh, A Kassin

Journal of Medical Cases 2018, vol 9 (9): 303-308

https://www.journalmc.org/index.php/JMC/article/view/3121/2467

■ Melkersson-Rosenthal syndrome: a rare cause of recurrent facial nerve palsy and acute respirator distress syndrome

Kosovali BD, Yavuz A, Yesiler FI, Bayar MK.

Case Rep Neurol Med. 2018 Jun 10;2018:137358

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015706/

■ Melkersson Rosenthal Syndrome.

Sepúlveda, Carolina, Sousa, Marta de and Ambrósio, Isabel

Medicina Interna, Dec 2017, vol.24, no.4, p.301-30

http://www.scielo.mec.pt/scielo.php?script=sci_arttext&pid=S0872-671X2017000400011&lng=pt&nrm=iso

■ Melkersson-Rosenthal syndrome – delay in the diagnosis of an early-onset oligosymptomatic variant

F Carolino, M Fernandes, J L Plácido

Porto Biomedical Journal 2016, vol 1 (1)

http://www.elsevier.es/en-revista-porto-biomedical-journal-445-articulo-melkersson-rosenthal-syndrome-delay-in-S244486641600012X

■ Successful treatment of Melkesson-Rosenthal syndrome (MRS) with hydroxychloroquine

I Puxddu, A Pucci, I Del Corso et AL

Clinical Dermatology 2015, vol 3 (2)

https://www.clinicaldermatology.eu/common/php/portiere.php?ID=e8350fb50e10e5cadb0e66d93eda13c8

■ Melkersson-Rosenthal syndrome as an early manifestation of mixed connective tissue disease

Dorota Jasinska, Jerzy Boczon

Eur J Med Res. 2015; 20: 100

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690344/

■ A rare syndrome in the differential diagnosis for angioedema

Z C Sozener, S Ozguclu, O Aydin et al

Journal of Medical Cases 2014, vol 5 (11): 579-582

https://www.journalmc.org/index.php/JMC/article/view/1543/1335

■ Isolated eyelid edema in Melkersson-Rosenthal syndrome: a case series

N G Rawlings, A A Valenzuela, L H Allen, J G Heathcote

Eye (Lond) 2012 Jan; 26(1): 163–166

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259600

■ Melkersson-Rosenthal syndrome: a forgotten

M D Karon, A A Valenzuela

Vision Panamerica 2012, vol 11 (1)

http://journals.sfu.ca/paao/index.php/journal/article/view/4/pdf

■ Successful treatment of Miescher´s cheilitis in Melkersson-Rosenthal syndrome with betamethasone injections and doxycycline

Lamia Oudrhiri, Soumiya Chiheb, Farida Marnissi, Soumaya Zamiati, Hakima Benchikhi

Pan Afr Med J. 2012; 13: 75

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567407/

■ . Corrección de “labio ondulado” en el síndrome de Melkersson-Rosenthal

Gutiérrez Gómez, C. et al

Cir. plást. iberolatinoam., Mar 2009, vol.35, no.1, p.79-84

http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0376-78922009000100015&lng=es&nrm=iso

■ Corrección de “labio ondulado” en el síndrome de Melkersson-Rosenthal

Gutiérrez Gómez, C. et al.

Cir. plást. iberolatinoam., Mar 2009, vol.35, no.1, p.79-8

http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0376-78922009000100015&lng=es&nrm=iso

■ Melkersson-Rosenthal syndrome with partial oculomotor nerve palsy

Mehmet Ufuk Aluclu, Ugur Keklikci, Aslan Guzel, Kaan Unlu, Mehmet Tatli

Ann Saudi Med. 2008 Mar-Apr; 28(2): 135–137

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6074525/

■ Síndrome de Melkersson Rosenthal: reporte de un caso y revisión de la literatura

Cosmelli Maturana, R., Bravo Ahumada, R. and Cordova Jara, L.

Rev Esp Cirug Oral y Maxilofac, Oct 2008, vol.30, no.5, p.348-352

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■ Síndrome de Melkersson-Rosenthal.

Gallego López, L., Llorente Pendás, S. and López-Arranz, J.S.

Rev Esp Cirug Oral y Maxilofac, Feb 2007, vol.29, no.1, p.57-63

http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-05582007000100007&lng=es&nrm=iso

■ Queilite granulomatosa associada à síndrome de Melkersson-Rosenthal

Gonçalves, Denise Utsch et al.

Rev. Bras. Otorrinolaringol., Fev 2007, vol.73, no.1, p.138-139

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72992007000100023&lng=en&nrm=iso

■ Queilitis granulomatosa de Miescher: Presentación de cinco casos.

Camacho Alonso, Fabio, Bermejo Fenoll, Ambrosio and López Jornet, Pía

Med. oral patol. oral cir. bucal (Ed.impr.), Dic 2004, vol.9, no.5, p.425-429

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■ Síndrome de Melkersson-Rosenthal: a propósito de un caso con parálisis facial bilateral.

López González, R. et al.

An. Med. Interna (Madrid), Mayo 2004, vol.21, no.5, p.55-56

http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-71992004000500013&lng=es&nrm=iso

■ Síndrome de Melkersson-Rosenthal: a propósito de un caso familiar.

Belló González, C. et al.

An. Med. Interna (Madrid), Ago 2002, vol.19, no.8, p.36-38.

http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-71992002000800006&lng=es&nrm=iso

■ Síndrome de Melkersson-Rosenthal: relato de casos e revisão da literatura.

Vilela, Daniela Salgado Alves et al

Rev. Bras. Otorrinolaringol., Out 2002, vol.68, no.5, p.755-760

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72992002000500024&lng=en&nrm=iso

■ Síndrome de Melkersson-Rosenthal: estudo clínico-patológico de um caso.

Lívia Maria Bittencourt, Nossa, Costa, Andrea Leone and Marback, Roberto Lorens

Arq. Bras. Oftalmol., Nov 2001, vol.64, no.6, p.573-57

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492001000600014&lng=en&nrm=iso

by Dr Paulo Fernando Leite

■ Cardiologia/Prevenção Cardiovascular

■ Estratificação de Risco Cardiovascular

Av Contorno 8351 – Conj 01

Belo Horizonte/MG/Brasil

Tel: 31 32919216 2917003 3357229

(- consulta particular –)

CRMMG: 7026

Email: pfleite1873@gmail.com

Vitamina D: Artigos de Revisão Online (Vitamin D: review)

Por Paulo Leite 24/11/2018

■ Deficiência da Vitamina D e Doenças Cardiovasculares.

Jorge, Antonio José Lagoeiro et al

Int. J. Cardiovasc. Sci., Aug 2018, vol.31, no.4, p.422-432

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■ Vitamin D supplementation, serum 25 (OH)D concentrations and cardiovascular disease risk factors: a systematic review and meta-analysis

Naghmeh Mirhosseini, Jacqueline Rainsbury, Samantha M. Kimball

Front Cardiovasc Med. 2018; 5: 87

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052909/

■ The impact of vitamin D in the treatment of essential hypertension

Christian Legarth, Daniela Grimm, Markus Wehland, Johann Bauer, Marcus Krüger

Int J Mol Sci. 2018, vol 19(2): 455

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855677/

■ Systematic review of vitamin D and hypertensive disorders of pregnancy

Karen M. O’Callaghan, Mairead Kiely

Nutrients. 2018, vol 10(3): 294

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872712/

■ Vitamina D y riesgo de preeclampsia: revisión sistematica y metaanalisis.

Serrano-Diaz, Norma Cecilia et al.

Biomedica, Mayo 2018, vol.38, suppl.1, p.43-53

http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-41572018000500043&lng=en&nrm=iso

■ Vitaminas antioxidantes en asma

Barrera-Mendoza, Columba Citlalli et al.

Rev. alerg. Méx., Mar 2018, vol.65, no.1, p.61-77

http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S2448-91902018000100061&lng=es&nrm=iso

■ Effects of vitamin D2 supplementation on vitamin D3 metabolism in health and CKD

Zona Batacchi, Cassianne Robinson-Cohen, Andrew N. Hoofnagle et al

Clin J Am Soc Nephrol. 2017 Sep 7; 12(9): 1498–1506

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■ Italian Association of Clinical Endocrinologists (AME) and Italian Chapter of the American Association of Clinical Endocrinologists (AACE) Position Statement: Clinical Management of Vitamin D Deficiency in Adults

Roberto Cesareo, Roberto Attanasio, Marco Caputo et al

on behalf of AME and Italian AACE Chapter

Nutrients. 2018, vol 10(5): 546.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986426/

■ Rationale and plan for vitamin D food fortification: a review and guidance paper

Stefan Pilz, Winfried März, Kevin D. Cashman et al

Front Endocrinol (Lausanne) 2018; vol 9: 373

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056629/

■ Vitamin D genomics: from in vitro to in vivo

Carsten Carlberg

Front Endocrinol (Lausanne) 2018; 9: 250

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974042/

■ Quality assessment of systematic of vitamin D, cognition and dementia

Fariba Aghajafari, Dimity Pond, Nigel Catzikiris, Ian Cameron

BJPsych Open. 2018 , vol 4(4): 238–249

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060489/

■ Is sunlight exposure enough to avoid wintertime vitamin D deficiency in United Kingdom populations groups?

Richard Kift, Lesley E. Rhodes, Mark D. Farrar, Ann R. Webb

Int J Environ Res Public Health. 2018 Aug; 15(8): 1624

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121420/

■ Optimizing calcium and vitamin D intake through diet and supplements

H P Kilim, H Rosen

Cleveland Clinic Journal of Medicine 2018, vol 85 (7): 543-550

https://www.mdedge.com/ccjm/article/168831/endocrinology/optimizing-calcium-and-vitamin-d-intake-through-diet-and

■ El rol de la vitamina D en la prevención de caídas en sujetos con sarcopenia

Fuentes-Barría, Héctor, Aguilera-Eguia, Raúl and González-Wong, Catalina

Rev. chil. nutr., Set 2018, vol.45, no.3, p.279-284

https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0717-75182018000400279&lng=es&nrm=iso

■ The biological activities of vitamin D and its receptor in relation to calcium and bone homeostasis, cancer, immune and cardiovascular systems, skin biology, and oral health

A. G. Khammissa, J. Fourie, M. H. Motswaledi et al

Biomed Res Int. 2018; 2018: 9276380

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987305/

■ Vitamin D in pediatric age: consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians

Giuseppe Saggese, Francesco Vierucci, Flavia Prodam et al

Ital J Pediatr. 2018; vol 44: 5

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941617/

■ Vitamin D and juvenile idiopathic arthritis

Sarah L. Finch, Alan M. Rosenberg, Hassan Vatanparast

Pediatr Rheumatol Online J. 2018; 16: 34

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956785/

■ Nordic walking training causes a decrease in blood cholesterol in elderly women supplemented with vitamin D

Krzysztof Prusik, Jakub Kortas, Katarzyna Prusik et al

Front Endocrinol (Lausanne) 2018; 9: 42

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826219/

■ Vitamin D supplementation guidelines for general population and groups at risk of vitamin D deficiency in Poland – Recommendations of the Polish Society of Pediatric Endocrinology and Diabetes and the Expert Panel with participation of Nationa Specialists Consultants and Representatives of Scientific Societies – 2018 Update

Agnieszka Rusińska, Paweł Płudowski, Mieczysław Walczak et al

Front Endocrinol (Lausanne) 2018; 9: 246

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990871/

■ The role of vitamin D in fertility and during pregnancy and lactation: a review of clinical data

Stefan Pilz, Armin Zittermann, Rima Obeid, et al

Int J Environ Res Public Health. 2018, vol 15(10): 2241

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210343/

■ Health risks of hypovitaminosis D: a review of new molecular insights

Daniela Caccamo, Sergio Ricca, Monica Currò, Riccardo Ientile

Int J Mol Sci. 2018, vol 19(3): 892

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877753/

by Dr Paulo Fernando Leite