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¨A síndrome antissintetase (SAS) é caracterizada por miosite, fenômeno de Raynaud, febre, doença pulmonar intersticial, artropatia e mãos de mecânico associados à presença de anticorpos contra a sintetase do RNAt especialmente anti-Jo-1. É uma miopatia inflamatória crônica e idiopática, doença autoimune sistêmica com a presença de anticorpos antissintetase tais como anti-Jo-1. A SAS anti-Jo-1 é caracterizada por envolvimento sistêmico de músculos (miosite), pulmões (doença pulmonar intersticial) e articular (poliartrite crônica), além de febre, fenômeno de Raynaud e “mãos mecânicas”.  É uma doença rara, com incidência na população geral ainda desconhecida e prevalência duas vezes maior no sexo feminino. A Doença Pulmonar Intersticial (DPI) é o principal determinante de morbidade e mortalidade na SAS. O comprometimento pulmonar é encontrado em mais de 60% dos casos e é a principal causa de morbidade. O envolvimento articular afeta 50% dos casos, com artralgia e/ou artrite, com ou sem erosões ósseas. Todos os pacientes apresentaram sintomas articulares no início da doença. Fenômeno de Raynaud é precoce em 2/3 dos pacientes, podendo anteceder à miosite por anos. Mais frequente naqueles anti-Jo-1 positivo. “Mãos de mecânico” é a hiperceratose, descamação e fissura em polpas digitais e parte lateral dos dedos, mais encontrada em antissintesase e doença intersticial pulmonar. Vasculite cutânea também foi descrita. Envolvimento cardíaco não difere em prevalência da polimiosite/dermatomiosite. Glomerulonefrite mesangial proliferativa tem sido observada, mas é rara e tem bom prognóstico. Testes para anti-Jo-1 devem ser feitos em pacientes com doença muscular inflamatória, bem como rastreamento para doença intersticial pulmonar. Pacientes com síndrome antissintetase freqüentemente necessitam de terapia imunossupressora para controlar as manifestações musculares e / ou pulmonares de sua doença. O cuidado de longo prazo desses pacientes exige atenção cuidadosa aos efeitos adversos e complicações da terapia imunossupressora crônica, bem como sequelas relacionadas à doença que podem incluir doença pulmonar intersticial progressiva, necessitando de transplante de pulmão, hipertensão pulmonar, malignidade e diminuição da sobrevida. ¨

 

■ Acute hypoxic respiratory failure secondary to antisynthetase syndrome: a case report and review of literature

Michelle Cancel, Mingchen Song

Respir Med Case Rep. 2019; 26: 288–291

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396011/

 

■ Coronary artery dilation associated with anti-synthetase syndrome in an adolescent

Karim Asi, Anand Gourishankar, Ankur Kamdar

Pediatr Rheumatol Online J. 2019; 17: 3

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329119/

 

■ Antisynthetase syndrome

Eri Noguchi, Akinori Uruha, Shigeaki Suzuki et al

JAMA Neurol. 2017 Aug; 74(8): 992–999.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710328/

 

■ Mechanic´s hands and hiker´s feet in antisynthetase syndrome

Madelaine Wernham, Steven J. Montague

CMAJ. 2017 Nov 6; 189(44): E1365

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675544/

 

■ Acute digital ischemia: a rare presentation of antisynthetase syndrome

Jin Ei Chan, Sandeep Palakodeti, Matthew J. Koster

Eur J Rheumatol. 2017 Mar; 4(1): 63–65

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335890/

 

■ Antysynthetase syndrome: an under-recognized cause of interstitial lung disease

Venkata Nagarjuna Maturu, Arjun Lakshman, Amanjit Bal et al

Lung India. 2016 Jan-Feb; 33(1): 20–26

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748659/

 

■ Antisynthetase syndrome (AAS) presenting as acute respiratory distress syndrome (ARDS) in a patient without myositis features

Venkat Kiran Kanchustambham, Swetha Saladi, Sarah Mahmoudassaf, Setu Patolia

BMJ Case Rep. 2016; 2016: bcr2016217624.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5174888/

 

■ The diagnosis and treatment of antisynthetase syndrome

L J Witt, J J Curran, M E Strek

Clin Pulm Med 2016, vol 23 (5): 218-226

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006392/

 

■ Syndrome in question: antisynthetase syndrome (anti-PL-7)

Ana Cláudia Cavalcante Esposito, Tatiana Cristina Gige, Hélio Amante Miot

An Bras Dermatol. 2016 Sep-Oct; 91(5): 683–685

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087238/

 

■ Antisynthetase syndrome: a case report

Mehwish Asif Qureshi, Edward Hoey, Timothy Fletcher, Zubair Ahmed

Quant Imaging Med Surg. 2016 Apr; 6(2): 207–209

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858466/

 

■ Myocarditis in patients with antisynthetase syndrom: prevalence, presentation, and outcomes

Céline Dieval, Christophe Deligny, Alain Meyer, et al

Medicine (Baltimore) 2015 Jul; 94(26): e798.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504539/

 

■ Síndrome Antissintetase: relato de dois casos e revisão da literatura.

Theilacker, Lívia Regina et al.

Rev. Bras. Reumatol., Abr 2015, vol.55, no.2, p.177-180

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042015000200177&lng=en&nrm=iso

 

■ Mesangial nephropathy and anti-synthetase syndrome: an odd association

E Morales, C Rabasco, N Panizo et al

Nefrologia 2015,vol 35 (4)

https://www.revistanefrologia.com/en-mesangial-nephropathy-anti-synthetase-syndrome-an-odd-association-articulo-S2013251415000723

 

■ Clinical spectrum time course in anti Jo-1 positive antisynthetase syndrome: results from na International Retrospective Multicenter Study

Lorenzo Cavagna, Laura Nuño, Carlo Alberto Scirè,et al

Medicine (Baltimore) 2015 Aug; 94(32): e1144

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616698/

 

■ In antisynthetase syndrome, ACPA are associated with severe and erosive arthritis: an overlapping rheumatoid arthritis and antisynthetase syndrome

Alain Meyer, Guillaume Lefevre, Guillaume Bierry et al

Medicine (Baltimore) 2015 May; 94(20): e523

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602869/

 

■ Fatal cardiac involvement complicating antisynthetase syndrome

Stefen Brady, Sunil Melath, Renata S Scalco, Henry Penn

BMJ Case Rep. 2014; 2014: bcr2014204409

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154036/

 

■ Inflammatory myopathy and interstitial lung disease in antisynthetase syndrome with PL-7 antibody

Sílvia Aguiar Rosa, Paulo Barreto, Marisa Mariano, Isabel Baptista

BMJ Case Rep. 2014; 2014: bcr2014204390

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187429/

 

■ Síndrome antissintetase: anti-PL-7, anti-PL-12 e anti-EJ.

Souza, Fernando Henrique Carlos de et al.

Rev. Bras. Reumatol., Ago 2013, vol.53, no.4, p.352-357

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042013000400007&lng=en&nrm=iso

 

■ Functional outcome and prognostic factors in anti-jo1 patients with antisynthetase syndrome

Isabelle Marie, Pierre-Yves Hatron, Patrick Cherin, et al

Arthritis Res Ther. 2013; 15(5): R149

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978997/

 

■ Doença pulmonar intersticial relacionada a miosite e a síndrome antissintetase.

Solomon, Joshua, Swigris, Jeffrey J and Brown, Kevin K

1. bras. pneumol., Fev 2011, vol.37, no.1, p.100-109

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132011000100015&lng=en&nrm=iso

 

■ The Antisynthetase syndrome

H C Patel, N N Lauder

The American Journal of Medicine 2011, vol 124 (9): e3-4

https://www.amjmed.com/article/S0002-9343(11)00175-6/fulltext

 

■ Síndrome antissintetase anti-Jo-1.

Shinjo, Samuel Katsuyuki and Levy-Neto, Mauricio

Rev. Bras. Reumatol., Out 2010, vol.50, no.5, p.492-50

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042010000500003&lng=en&nrm=iso

 

■ Médico Responsável: Dr Paulo Fernando Leite

Cardiologia – CRMMG: 7026

Centro Médico Unimed BH

Belo Horizonte/Minas Gerais/Brasil

Email: pfleite1873@gmail.com

■ Rheumatoid arthritis: Are psychological factors effective in disease flare?

Volkan Yılmaz, Ebru Umay, İbrahim Gündoğdu et al

Eur J Rheumatol. 2017 Jun; 4(2): 127–132

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473448/

 

■ Is male rheumatoid arthritis an occupational disease? A review

Dan Murphy, David Hutchinson

Open Rheumatol J. 2017; 11: 88–105

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585464/

 

■ Can rheumatoid vasculitis predate a diagnosis of rheumatoid arthritis?

Sarah Sacks, Alan Steuer

Eur J Rheumatol. 2017 Mar; 4(1): 57–58

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335888/

 

■ Is joint pain in patients with arthralgia suspicious for progressionto rheumatoid arthritis explained by subclinical inflammation? – A cross-seccional MRI-study

L.E. Burgers, R.M. ten Brinck, A.H.M. van der Helm-van Mil

Rheumatology (Oxford) 2019 Jan 1; 58(1): 86–93

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319603/

 

■ From patients with arthralgia, pre-RA and recently diagnosed RA: What is the current status of understanding RA pathogenesis?

M Molendijk, H M W Hazes, E Lubberts

RMD Open 2018, vol 4 (1)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822638/

 

■ What is the additional value of MRI of the foot to the hand in undifferentiated arthritis to predict rheumatoid arthritis development?

1. J. Dakkak, D. M. Boeters, A. C. Boer et a

Arthritis Res Ther. 2019; 21: 56

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376768/

 

■ Can baseline ultrasound results help to predict failure to achieve DAS28 remission after 1 year of tight control treatment in early RA patients?

1. F. Ten Cate, J. W. G. Jacobs, W. A. A. Swen et al

Arthritis Res Ther. 2018; 20: 15

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791342/

 

■ Giant cell arteritis, polymyalgia rheumatic, and late-onset rheumatoid arthritis: Can they be components of a single disease process in elderly patients?

Cengiz Korkmaz, Pınar Yıldız

Eur J Rheumatol. 2017 Jun; 4(2): 157–160

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473456/

 

■ The rheumatoid hand in the light of fluorescence: a diagnostic technique of the future?

Paweł Żuchowski, Marzena Waszczak-Jeka, Szymon Kudlicki, Sławomir Jeka

Reumatologia. 2019; 57(1): 45–49

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409828/

 

■ Parasitoses intestinais: efeito protetor na artrite reumatoide?

Oliveira, Sandra Maximiano de et al.

Rev. Bras. Reumatol., Oct 2017, vol.57, no.5, p.461-465

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042017000500461&lng=pt&nrm=iso&tlng=pt (portuguese)

 

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042017000500461&lng=pt&nrm=iso&tlng=en (english)

 

■ A cluster of intracellular parasitic infections among patients on biological DMARDs – the tip of the iceberg

H Hammarström, L Dovetal, A Calander

Rheumatology Advances in Practice 2018, vol 2 (2)

https://academic.oup.com/rheumap/article/2/2/rky048/5220774

 

■ High prevalence of gallstone disease in rheumatoid arthrtitis: A new comorbidity related to dyslipidemia?

M C Garcia-Gómez, E de Lama, S Ordoñez-Palau et al

Reumatol Clin 2018, vol 14: 84-89

http://www.reumatologiaclinica.org/es-high-prevalence-gallstone-disease-in-articulo-S1699258X17301729

 

■ Qué papel juega la actividad de la enfermedad en el riesgo cardiovascular de la artrhritis rheumatoid?

M A R Huaranga, M D M Sánchez, M A Z D de la Espina et al

Reumatol Clin 2018, vol 14: 339-345

http://www.reumatologiaclinica.org/es-que-papel-juega-actividad-enfermedad-articulo-S1699258X17300839

 

■ Valor de la ecografia con Doppler de poder en pacients con arthritis reumatoide en remissión clínica: Reclassificación de la actividad de la enfermedad?

F Vergara, S Ruta, J Rosa et al

Reumatol Clin 2018, vol 14: 202-206

http://www.reumatologiaclinica.org/es-valor-ecografia-con-doppler-poder-articulo-S1699258X17300268

 

■ Is the serum oxytocin level altered by treatment in rheumatoid arthritis patients complicated with depression?

Yusuke Miwa, Hidekazu Furuya, Ryo Yanai et al

Eur J Rheumatol. 2018 Mar; 5(1): 22–26

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895146/

 

■ Tumor-associated antigens in rheumatoid arthritis interstitial lung disease or malignancy

Gökhan SARGIN, Reyhan KÖSE, Taşkın ŞENTÜRK

Arch Rheumatol. 2018 Dec; 33(4): 431–437

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409176/

 

■ What causes a small increase in radiographic progression in rheumatoid arthritis patients tapering TNF inhibitors

C A M Bouman, A A den Broeder, A van der Maas et al

RMD Open 2017, vol 3 (1)

https://rmdopen.bmj.com/content/3/1/e000327

 

■ Right drug, right patient, right time: Aspiration or future promise for biologics in rheumatoid arthritis?

Vasco C. Romão, Edward M. Vital, João Eurico Fonseca, Maya H. Buch

Arthritis Res Ther. 2017; 19: 239

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655983/

 

■ Terapia ocupacional na artrite reumatoide: o que o reumatologista precisa saber?

Almeida, Pedro Henrique Tavares Queiroz de et al.

Rev. Bras. Reumatol., Jun 2015, vol.55, no.3, p.272-280

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042015000300272&lng=pt&nrm=iso

 

■ Médico Responsável: Dr Paulo Fernando Leite

Cardiologia – CRMMG: 7026

Belo Horizonte/Minas Gerais/Brasil

Email: pfleite1873@gmail.com