Blog - INTERNET MÉDICA

Trombofilia Online (Thrombophilia)

Por Paulo Leite 06/11/2019

A trombofilia é definida como tendência à trombose decorrente de alterações hereditárias (deficiência de proteína C, S e antitrombina; mutação do fator V de Leiden − FVL; e mutação do gene da protrombina) ou adquiridas da coagulação (síndrome antifosfolípide), que levam a estado pró-trombótico, o qual predispõe a tromboses venosas ou arteriais. A etiologia da trombose (oclusão arterial ou venosa do vaso sanguíneo por um coágulo) é multifatorial, e a presença de uma alteração laboratorial genética ou adquirida de trombofilia é apenas um dos muitos fatores que determinam seu risco, tendo pouca prevalência na população geral. As principais trombofilias hereditárias em ordem decrescente de prevalência são: Fator V de Leiden, Mutação do fator II (protrombina), Deficiência de anitrombina, Deficiência de proteína C, Deficiência de proteína S, Disfibrinogenemia e Homocistinúria homozigótica.

■ Consenso sobre a investigação de trombofilia em mulheres e manejo clínico.

Nascimento, Claudia Mac Donald Bley et al

Einstein (São Paulo), 2019, vol.17, no.3

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082019000300900&lng=pt&nrm=iso&tlng=pt (portuguese)

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082019000300900&lng=pt&nrm=iso&tlng=en (english)

■ American Society of Hematology 2018 guidelines for management of venous thromboembolism: venous thromboembolism in the contex of pregnancy

Shannon M. Bates, Anita Rajasekhar, Saskia Middeldorp et al

Blood Adv. 2018 Nov 27; 2(22): 3317–3359

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258928/

■ Inherited thrombophilia and portal vein thrombosis in cirrhosis: a systematic review and meta-analysis

Steven D. Ma, Jennifer Wang, Dmitri Bezinover et al

Res Pract Thromb Haemost. 2019 Oct; 3(4): 658–667.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781918/

■ Testosterone therapy, thrombophilia, venous thromboembolism, and thrombotic events

Charles J. Glueck, Naila Goldenberg, Ping Wang

J Clin Med. 2019 Jan; 8(1): 11

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352146/

■ The obstetric complications in women with hereditary thrombophilia

Diana Mitriuc, Olga Popuşoi, Rodica Catrinici, Valentin Friptu

Med Pharm Rep. 2019, vol 92(2): 106–110

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510366/

■ Hereditary thrombophilia by factor V Leiden G1691A (heterozygous) and FII prothrombin G20210A (homozygous) mutations in a patient with ischemic cerebrovascular accident

Ruiz, Leonardo G. P. et al.

Bras. Patol. Med. Lab., Apr 2018, vol.54, no.2, p.92-94

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442018000200092&lng=pt&nrm=iso&tlng=en

■ Thrombosis in children: Which test to whom, when and how much necessary?

Tiraje Celkan, Gürcan Dikme

Turk Pediatri Ars. 2018 Mar; 53(1): 1–9

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070222/

■ Maternal thrombophilia and recurrent miscarriage – Is there evidence that heparin is indicated as prophylaxis against recurrence?

Ana-Luisa Stefanski, Christoph Specker, Rebecca Fischer-Betz et al

Geburtshilfe Frauenheilkd. 2018 Mar; 78(3): 274–282

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862552/

■ Use of current thrombophilia screening in young patients with stroke and TIA

Vafa Alakbarzade, Alice Taylor, Marie Scully, Robert Simister, Arvind Chandratheva

Stroke Vasc Neurol. 2018 Dec; 3(4): 231–236

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312074/

■ Therapeutic options in pregnancy women with thrombophilia depending on the genetic mutations- a prospective study

J G Nacea, I Rotary, A M Patrascu, N Cern

Curr Health Sci J. 2018 Jul-Sep; 44(3): 288–29

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311225/

■ Pregnancy, thrombophilia, and the risk of a first venous thrombosis systematic review and bayesian meta-analysis

F Nanne Croles, Kazem Nasserinejad, Johannes J Duvekot et al

BMJ. 2017; 359: j445

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657463/

■ ¨To test or not to test¨ the arguments for and against thrombophilia testing in obstetrics

Laura Ormesher, Louise E Simcox, Clare Tower, Ian A Greer

Obstet Med. 2017 Jun; 10(2): 61–66

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480652/

■ Preventing venous thromboembolism during pregnancy and postpartum: crossing the threshold

Leslie Skeith

Hematology Am Soc Hematol Educ Program. 2017 Dec 8; 2017(1): 160–167

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142533/

■ Marcadores Séricos para Trombofilia em Gestantes com Lúpus Eritematoso Sistêmico.

Oliveira, Vanessa Marcon de et al

Rev. Bras. Saude Mater. Infant., Dec 2017, vol.17, no.4, p.833-842

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292017000400833&lng=pt&nrm=iso&tlng=pt (portuguese)

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292017000400833&lng=pt&nrm=iso&tlng=en (english)

■ Tromboprofilaxia e desfechos materno-fetais de mulheres com marcadores séricos para trombofilias hereditárias e antecedentes de complicações obstétricas.

Ferreira, Cristiane Munaretto et al

Rev. Bras. Saude Mater. Infant., Dec 2017, vol.17, no.4, p.693-698.

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292017000400693&lng=pt&nrm=iso&tlng=pt (portuguese)

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292017000400693&lng=pt&nrm=iso&tlng=en (english)

■ Guidance for the evaluation and treatment of hereditary and acquired thrombophilia

Scott M. Stevens, Scott C. Woller, Kenneth A. Bauer et al

J Thromb Thrombolysis. 2016; 41: 154–164

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715840/

■ Assessment of algorithms to identify patients with thrombophilia following venous thromboembolism

Thomas Delate, Wendy Hsiao, Benjamin Kim et al

Thromb Res. 2016 Jan; 137: 97–102

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123887/

■ Hereditary risk factors for thrombophilia and probability of venous thromboembolism during pregnancy and the puerperium

Andrea Gerhardt, Rüdiger E. Scharf, Ian A. Greer, Rainer B. Zotz

Blood. 2016 Nov 10; 128(19): 2343–2349

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813719/

■ Prevalence of factor V Leiden in patients with venous thrombosis.

Michel, Cristiane Aparecida et al.

Bras. Patol. Med. Lab., Sept 2016, vol.52, no.4, p.227-232

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442016000400227&lng=pt&nrm=iso&tlng=en

■ Thrombophilia testing patterns among patients with acute venous thromboembolism

M R Meyer, D M Witt, T Dilate et al

Thromb Res 2015, vol 16 (6): 1160-1164

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727748/

■ Manejo obstétrico de la deficiencia hereditaria de antitrombina durante el embarazo y puerperio. Dos casos clínicos

Martínez, Milagros Cruz et al.

Rev. Bras. Saude Mater. Infant., Dic 2015, vol.15, no.4, p.441-446

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-38292015000400441&lng=pt&nrm=iso

■ Resultados gestacionais e trombofilias em mulheres com história de óbito fetal de repetição

Barros, Venina Isabel Poço Viana Leme de et al.

Rev. Bras. Ginecol. Obstet., Fev 2014, vol.36, no.2, p.50-55

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032014000200050&lng=pt&nrm=iso

■ Clinical profile, common thrombophilia markers and risk factors in 85 young Indian patients with arterial thrombosis.

Mishra, Mahendra Narain, Kalra, Ravi and Rohatgi, Shalesh

Sao Paulo Med. J., 2013, vol.131, no.6, p.384-388

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802013000600384&lng=pt&nrm=iso&tlng=en

■ Analysis of factor V Leiden and prothrombin mutations in patients with suspected thrombophilia in São Paulo state-Brazil

Herkenhoff, Marcos Edgar et al.

Bras. Patol. Med. Lab., June 2013, vol.49, no.3, p.169-173

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442013000300003&lng=pt&nrm=iso&tlng=en

■ Eficácia de intervenção com enoxaparina baseada em sistema de pontuação nos desfechos perinatais de gestantes com trombofilia

Figueiró-Filho, Ernesto Antonio et al

Rev. Bras. Ginecol. Obstet., Out 2012, vol.34, no.10, p.459-465.

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032012001000005&lng=pt&nrm=iso

■ Marcadores séricos de trombofilias hereditárias e anticorpos antifosfolípides em gestantes com antecedentes de pré-eclâmpsia grave.

Figueiró-Filho, Ernesto Antonio et al.

Rev. Bras. Ginecol. Obstet., Jan 2012, vol.34, no.1, p.40-46

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032012000100008&lng=pt&nrm=iso

■ Análise da mutação G20210A no gene da protrombina (fator II) em pacientes com suspeita de trombofilia no sul do Brasil.

Herkenhoff, Marcos Edgar et al.

Bras. Patol. Med. Lab., Abr 2012, vol.48, no.2, p.85-89

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442012000200003&lng=pt&nrm=iso

■ Hemofilia Online (Hemophilia) no Blog Internet Médica

https://internetmedica.com.br/hemofilia-online-hemophilia/

■ Hemoblobinúria Paroxística Noturna Online (Paroxysmal Nocturnal Hemoglobinúria) no Blog Internet Médica

https://internetmedica.com.br/hemoglobinuria-paroxistica-noturna-online-paroxysmal-nocturnal-hemoglobinuria/

■ Hematologia: Diretrizes Médicas Online (Hematology: Guidelines)

https://internetmedica.com.br/hematologia-diretrizes-medicas-online-hematology-guidelines/

■ Hematologia: Organizações Médicas Online (Hematology: Medical Organizations) no Blog Internet Médica

https://internetmedica.com.br/hematologia-organizacoes-medicas-online/

■ Dr Paulo Fernando Leite

Cardiologia/Prevenção Cardiovascular

Estratificação de Risco Cardiovascular

Consultório: Rua Padre Rolim 815/sala 601

Tel: 33245518

CRMMG: 7026

Email: pfleite1873@gmail.com

Data: nov 2019

Síndrome Metabólica Online (Metabolic Syndrome)

Por Paulo Leite 05/11/2019

A sídrome metabólica (SM) é um distúrbio multifatorial representado por um conjunto de fatores de risco cardiovascular usualmente relacionados à deposição central de gordura e à resistência à insulina. Para diagnóstico da SM, o indivíduo deve apresentar a combinação de pelo menos três dos cinco componentes: circunferência abdominal elevada, hipertrigliceridemia, redução do HDL colesterol, hipertensão arterial sistêmica e hiperglicemia. A associação da SM com a doença cardiovascular eleva a mortalidade geral em aproximadamente 1,5 vezes e a cardiovascular em 2,5 vezes. A associação entre adiposidade abdominal e aterosclerose subclínica foi documentada em diferentes populações. O diagnóstico de síndrome metabólica requer a presença de três ou mais dos critérios abaixo mencionados:

– Obesidade abdominal: (circunferência abdominal > 94 cm – homens; e > 80 cm – mulheres)

-Triglicérides: > 150 mg/dL

– HDL-colesterol: < 40 mg/dL (homens) e < 50 mg/dL (mulheres)

– Pressão arterial sistólica: 130 mmHg ou tratamento para hipertensão arterial

– Pressão arterial diastólica: > 85 mmHg ou tratamento para hipertensão arterial

– glicemia de jejum: 100 mg/dL

■ Epidemiological study of metabolic syndrome in Brazilian soldiers.

Fortes, Marcos de Sá Rego et al.

Arch. Endocrinol. Metab., Aug 2019, vol.63, no.4, p.345-350

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972019000700345&lng=en&nrm=iso

■ Effects of a new approach of aerobic interval training on cardiac autonomic modulation and cardiovascular parameters of metabolic syndrome subjects

Vanzella, Laís Manata et al.

Arch. Endocrinol. Metab., Apr 2019, vol.63, no.2, p.148-156

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972019000200148&lng=en&nrm=iso

■ Indicadores de Adiposidade Abdominal e Espessura Médio-Intimal de Carótidas: Resultados do Estudo Longitudinal de Saúde do Adulto – ELSA-Brasil

Eickemberg, Michaela et al

Arq. Bras. Cardiol., Mar 2019, vol.112, no.3, p.220-227

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2019000300220&lng=pt&nrm=iso&tlng=pt (Portuguese)

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2019000300220&lng=pt&nrm=iso&tlng=en (English)

■ Anthropometric measurements as a potential non-invasive alternative for the diagnosis of metabolic syndrome in adolescents.

Mastroeni, Silmara Salete de Barros Silva et al.

Arch. Endocrinol. Metab., Jan 2019, vol.63, no.1, p.30-3

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972019000100030&lng=en&nrm=iso

■ Physical activity, cardiorespiratory fitness, and the metabolic syndrome

Jonathan Myers, Peter Kokkinos, Eric Nyelin

Nutrients. 2019 Jul; 11(7): 1652

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683051/

■ Mechanisms underlying metabolic syndrome-related sarcopenia and possible therapeutic measures

María Esther Rubio-Ruiz, Verónica Guarner-Lans, Israel Pérez-Torres, María Elena Soto

Int J Mol Sci. 2019, vol 20(3): 647

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387003/

■ The liver in children with metabolic syndrome

Ebe D’Adamo, Valeria Castorani, Valerio Nobili

Front Endocrinol (Lausanne) 2019; 10: 514

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687849/

■ Serum uric acid to HDL-cholesterol ratio is a strong predictor of metabolic syndrome in type 2 diabetes mellitus

Kocak, M. Zahid et al.

Rev. Assoc. Med. Bras., Jan 2019, vol.65, no.1, p.9-15

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000100009&lng=pt&nrm=iso&tlng=en

■ Potential protective effect of oleanolic acid on the components of metabolic syndrome: a systematic review

Ángel Fernández-Aparicio, Jacqueline Schmidt-RioValle, Javier S. Perona et al

J Clin Med. 2019, vol 8(9): 1294

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780804/

■ The Prevalence of Metabolic Syndrome in the Different Phenotypes of Polycystic Ovarian Syndrome

Tavares, Aleide and Barros, Romualda Castro Rêgo

Rev. Bras. Ginecol. Obstet., Jan 2019, vol.41, no.1, p.37-43

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032019000100037&lng=pt&nrm=iso&tlng=en

■ Detection of metabolic syndrome burden in healthy young adults may enable timely introduction of disease prevention

Anja Šoštarič, Barbara Jenko, Nada Rotovnik Kozjek, et al

Arch Med Sci. 2019 Sep; 15(5): 1184–1194

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764305/

■ Practical guidance for interventions in adults with metabolic syndrome: diet and exercise vs changes in body composition

Enrique Albert Pérez, Marina Poveda González, Rosa María Martínez-Espinosa, Mariola D Molina Vila, Manuel Reig García-Galbis

Int J Environ Res Public Health. 2019, vol 16(18): 3481

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765968/

■ Evidências científicas sobre a associação entre burnout e síndrome metabólica: revisão integrativa

Merces, Magno Conceição das et al.

Acta paul. enferm., Ago 2019, vol.32, no.4, p.470-476

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-21002019000400470&lng=en&nrm=iso

■ Cardiovascular risk and obesity

C Cercato, F A Fonseca

Diabetol Metab Syndr 2019, vol 11: 74

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712750/

■ Metabolic syndrome components are associated with oxidative stress in overweight and obese patients

Morelli, Nayara Rampazzo et al.

Arch. Endocrinol. Metab., May 2018, vol.62, no.3, p.309-318

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972018000300309&lng=en&nrm=iso

■ Síndrome Metabólica e Resistência Insulínica pelo Homa-IR no Climatério

Fonseca, Érika Joseth Nogueira da Cruz et al

Int. J. Cardiovasc. Sci., May 2018, vol.31, no.3, p.201-208

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472018000300201&lng=en&nrm=iso&tlng=pt (portuguese)

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472018000300201&lng=en&nrm=iso&tlng=en (english)

■ Long-term weight loss and metabolic health in adults concerned with maintaining or losing weight: findings from NHANES

G Knell, Q Li, K P Gabriel, K Shuval

Mayo Clin Proc 2018 vol 93 (11): 1611-1616

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526934/

■ Poor sleep quality is associated with insulin resistance in postmenopausal women with and without metabolic syndrome

Christopher E. Kline, Martica H. Hall, Daniel J. Buysse, et al

Metab Syndr Relat Disord. 2018 May 1; 16(4): 183–189.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931175/

■ Diagnostic imaging in the management of patients with metabolic syndrome

Seo Rin Kim, Lilach O. Lerman

Transl Res. 2018 Apr; 194: 1–18

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839955/

■ Metabolic syndrome and psoriasis: a study in 97 patients.

Ferdinando, Lana Bassi et al.

Rev. Assoc. Med. Bras., Apr 2018, vol.64, no.4, p.368-373

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302018000400368&lng=pt&nrm=iso&tlng=en

■ Características Relacionadas à Síndrome Metabólica em Indivíduos com Hipertensão Controlada e Hipertensão Resistente.

Catharina, Arthur Santa et al

Arq. Bras. Cardiol., June 2018, vol.110, no.6, p.514-521

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018000600514&lng=pt&nrm=iso&tlng=pt (Portuguese)

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018000600514&lng=pt&nrm=iso&tlng=en (English)

■ Prevalência e Fatores Associados com a Síndrome Metabólica na População Adulta Brasileira: Pesquisa Nacional de Saúde – 2013

Ramires, Elyssia Karine Nunes Mendonça et a

Arq. Bras. Cardiol., May 2018, vol.110, no.5, p.455-466

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018000500455&lng=pt&nrm=iso&tlng=pt

■ Prevalência de Síndrome Metabólica e Escore de Risco de Framingham em Homens Vegetarianos e Onívoros Aparentemente Saudáveis

Navarro, Julio Cesar Acosta et al

Arq. Bras. Cardiol., May 2018, vol.110, no.5, p.430-437

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018000500430&lng=pt&nrm=iso&tlng=pt (portuguese)

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018000500430&lng=pt&nrm=iso&tlng=en (english)

■ Síndrome Metabólica e Resistência Insulínica pelo Homa-IR no Climatério

Fonseca, Érika Joseth Nogueira da Cruz et al

Int. J. Cardiovasc. Sci., May 2018, vol.31, no.3, p.201-208

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472018000300201&lng=pt&nrm=iso&tlng=pt (Portuguese)

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472018000300201&lng=pt&nrm=iso&tlng=pt (English)

■ The global epidemic of the metabolic syndrome

M G Saklayen

Curr Hypertens Rep 2018, vol 20 (2): 12

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866840/

■ Metabolic syndrome and the skin: a more than superficial association. Reviewing, the association between skin diseases and metabolic syndrome and a clinical decision algorithm for high risk patients

E C Stefanadi, G Dimitrakakes, C Antoniou et al

Diabetol Metab Syndr 2018, vol 10: 9

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822485/

■ Impact of self-reported fasting duration on lipid profile variability, cardiovascular risk stratification and metabolic syndrome diagnosis.

Janovsky, Carolina Castro Porto Silva et al.

Arch. Endocrinol. Metab., Mar 2018, vol.62, no.2, p.187-192

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972018000200187&lng=en&nrm=iso

■ Metabolic syndrome and masked hypertension among Africans Americans: The Jackson Heart Study

Lisandro D. Colantonio, D. Edmund Anstey, April P. Carson et al

J Clin Hypertens (Greenwich). 2017 Jun; 19(6): 592–600

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697142/

■ Establishing post mortem criteria for the metabolic syndrome: an autopsy based cross-sectional study

M R Christensen, A Bugge, M E Malik et al

Diabetol Metab Syndr 2018, vol 10: 36

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918842/

■ Lifestyle recommendations for the prevention and management of metabolic syndrome: an international panel recommendation

Pablo Pérez-Martínez, Dimitri P. Mikhailidis, Vasilios G. Athyros et al

Nutr Rev. 2017 May; 75(5): 307–326

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914407/

■ Preditores de síndrome metabólicac em idosos: uma revisão

C C de Oliveira, E D da Costa, A K C Roriz et al

International Journal of Cardiovascular Sciences 2017, vol 30 (4): 343-353

http://www.onlineijcs.org/sumario/30/pdf/v30n4a09.pdf

■ Predictor of 25-hydroxyvitamin D status among individuals with metabolic syndrome: a cross-sectional study

S L S Aquino, A T O da Cunha, H T Pereira et al

Diabetol Metab Syndr 2018, vol 10: 45

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987652/

■ Predictors of Metabolic Syndrome in the Elderly: A Review

Oliveira, Carolina Cunha de et al.

Int. J. Cardiovasc. Sci., Aug 2017, vol.30, no.4, p.343-353

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472017000400343&lng=en&nrm=iso&tlng=pt

■ Peripheral polyneuropathy in severely obese patients with metabolic syndrome but without diabetes: Association with low HDL-cholesterol.

Nienov, Otto Henrique et al.

Rev. Assoc. Med. Bras., Apr 2017, vol.63, no.4, p.324-331

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000400324&lng=pt&nrm=iso

■ Caracterização da variabilidade da frequência cardíaca em indivíduos com síndrome metabólica

Rodrigues, Jhennyfer Aline Lima et al.

Rev Bras Med Esporte, Maio 2017, vol.23, no.3, p.208-21

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-86922017000300208&lng=pt&nrm=iso

■ Relationships between adiponectin levels, the metabolic syndrome, and type 2 diabetes: a literature review.

Frankenberg, Anize Delfino von, Reis, André F. and Gerchman, Fernando

Arch. Endocrinol. Metab., Dec 2017, vol.61, no.6, p.614-622

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972017000600614&lng=en&nrm=iso

■ Systematic review of metabolic syndrome biomarkers: a panel for early detection, management, and risk stratification in the West Virginian population

K Srikanthan, A Feyh, H Visweshwaar et al

Int J Med Sci 2016, vol 13 (1); 25-38

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716817/