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¨Em 1963, Liddle e colaboradores descreveram uma doença renal de caráter familiar, com características clínicas e laboratoriais semelhantes ao hiperaldosteronismo primário, porém com liberação de aldosterona em concentrações mínimas. O quadro caracterizava-se por hipertensão grave, expansão do volume extracelular e hipocalemia. Atualmente, a síndrome é considerada uma doença autossômica dominante, com expressão clínica variável, cuja alteração principal ocorre nos canais de sódio, e é secundária a mutações em suas subunidades beta ou gama. A síndrome de Liddle é caracterizada por uma transmissão autossômica dominante de penetrância variável, que promove o aparecimento de mutações nas sub-unidades b e g do canal epitelial de sódio, deletando a terminação C citoplasmática. A conseqüência das mutações, assim como em outras formas mendelianas de hipertensão, envolve o aumento preferencial no balanço de sal, através de uma excessiva reabsorção de sódio pelo canal epitelial de sódio no túbulo renal distal, podendo ser freqüente o achado de hipocalemia. Neste sentido, o tratamento com inibidores específicos desses canais, como o triantereno e a amilorida, pode reverter tanto a hipocalemia quanto a hipertensão, mas o mesmo não acontece com a espironolactona, um inibidor do receptor mineralocorticóide. Têm sido descritos casos isolados de pacientes com a síndrome de Liddle que se submeteram ao transplante renal como forma de tratamento¨.

 

■ Liddle´s syndrome mechanisms, diagnosis and management

B T Enslow, J D Stockland, J M Berman

Inter Blood Press Control 2019, vol 12: 13-22

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731958/

 

■ Overview of monogenic or mendelian forms of hypertension

Raina R, Krishnappa V, Das A, Amin H, Radhakrishnan Y, Nair NR, Kusumi K.

Front Pediatr. 2019 Jul 1;7:263

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613461/

 

■ Liddle syndrome: review of the literature and description of a new case

M Tetti, S Monticone, P Mulatero

Int J Mol Scie 2018, vol 19 (3): pii: E812

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877673/

 

■ Liddle syndrome due to a novel mutation in the y subunit of the epitelial sodium channel (ENaC) in family from Russia: a case report

Kozina AA, Trofimova TA, Okuneva EG, Baryshnikova NV et al

BMC Nephrol. 2019 Oct 26;20(1):38

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815463/

 

■ A novel frameshift mutation of SCNN1G causing Liddle syndrome with normokalemia

Fan P, Zhao YM, Zhang D, Liao Y et al

Am J Hypertens. 2019 Jul 17;32(8):752-758

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636789/

 

■ A family with Liddle´s syndrome caused by a new c.1721 deletion mutation in the epitelial sodium channel B-subunit

Ding X, Jia N, Zhao C, Zhong Y, et al

Exp Ther Med. 2019 Apr;17(4):2777-2784

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425271/

 

■ Threee reportedly unrelated families with Liddle syndrome inherited from a common ancestor

Pagani L, Diekmann Y, Sazzini M, t a

Hypertension. 2018 Feb;71(2):273-279

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767121/

 

■ Liddle´s syndrome in na African male duet to a novel frameshift mutation in the beta-subunit of the epithelian sodium channel gene

Freercks R, Meldau S, Jones E, Ensor J, et al

Cardiovasc J Afr. 2017 Sep 23;28(4):e4-e6

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730729/

 

■ A missense mutation in the extracelular domain of alpha-ENAC causes Liddle syndrom

Salih M, Gautschi I, van Bemmelen MX, Di Benedetto M, et al

J Am Soc Nephrol. 2017 Nov;28(11):3291-3299

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661275/

 

■ Liddle syndrome in association with aortic dissection

Abbass A, D’Souza J, Khalid S, Asad-Ur-Rahman F, Limback J, Burt J, Shah R.

Cureus. 2017 May 4;9(5):e1225

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453742/

 

■ Liddle syndrome: clinical and genetic profiles

Cui Y, Tong A, Jiang J, Wang F, Li C.

J Clin Hypertens (Greenwich). 2017 May;19(5):524-529

https://onlinelibrary.wiley.com/doi/full/10.1111/jch.12949

 

■ Management of Liddle syndrome in pregnancy: a case report and literature review

Awadalla M, Patwardhan M, Alsamsam A, Imran N.

Case Rep Obstet Gynecol. 2017;2017:627946

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370477/

 

■ A therapeutic challenge: Liddle´syndrome managed with amiloride during pregnancy

A Caretto, L Primerano, M Rondinelli

Case Rep Obst Gynecol 2014, 2014: 156250

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158429/

 

■ A clinical phenotype mimicking essential hypertension in

E Rossi, E Farnetti, D Nicoli et al

Am J Hypertens 2011, vol 24 (8): 930-935

https://academic.oup.com/ajh/article/24/8/930/2282127

 

■ Genetics of hypertensive syndrome

A Martinez-Aguayo, c Fardella

Hormone Research in Pediatrics 2009, vol 71: 253-259

https://www.karger.com/Article/FullText/208798

 

■ A genética das síndromes hipertensivas endócrinas.

Drager, Luciano F. and Krieger, José Eduardo

Arq Bras Endocrinol Metab, Out 2004, vol.48, no.5, p.659-665

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302004000500011&lng=en&nrm=iso

 

■ Síndrome de Liddle: diagnóstico tardio de causa rara de hipertensão arterial.

Silva, Ana Cristina Simões e et al.

1. Pediatr. (Rio J.), 2002, vol.78, no.3, p.251-254

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572002000300015&lng=en&nrm=iso

 

■  Dr Paulo Fernando Leite

Cardiologia/Prevenção Cardiovascular

Estratificação de Risco Cardiovascular

Consultório: Rua Padre Rolim 815/sala 601

Tel: 33245518

CRMMG: 7026

Email: pfleite1873@gmail.com

Data: Jan 2020

■ Sleep-related disorders in Neurology and Psychiatry

Jan Rémi, Thomas Pollmächer, Kai Spiegelhalder, Claudia Trenkwalder, Peter Young

Dtsch Arztebl Int. 2019 Oct; 116(41): 681–688

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6865193/

 

■ Sleep problems in advanced disease

Andrew Davies

Clin Med (Lond) 2019 Jul; 19(4): 302–305

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752246/

 

■ Sleep disorders in pregnancy

Rosalia Silvestri, Irene Aricò

Sleep Sci. 2019 Jul-Sep; 12(3): 232–239

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932848/

 

■ Sleep Medicine: insomnia and sleep

Pradeep C. Bollu, Harleen Kaur

Mo Med. 2019 Jan-Feb; 116(1): 68–75.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390785/

 

■ Role of optimum diagnosis and treatment of insomnia in patientes with hypertension and diabetes: a review

Himanshu Garg

J Family Med Prim Care. 2018 Sep-Oct; 7(5): 876–883

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259555/

 

■ Sueño y sistema inmune

Rico-Rosillo, María Guadalupe and Vega-Robledo, Gloria Bertha

Rev. alerg. Méx., Jun 2018, vol.65, no.2, p.160-170

http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S2448-91902018000200160&lng=es&nrm=iso

 

■ Antidepressant for insomnia in adults

David S Baldwin, Beth Stuart, Gosia Lipinska et al

Cochrane Database Syst Rev. 2018 May; 2018(5): CD010753

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494576/

 

■ Prescribing practices of quetiapine for insomnia at a tertiary care inpatient and adolescente psychiatry unit: a continuous quality improvement Project

Elaine Stephanie Chow, Azadeh Zangeneh-Kazemi, Olabode Akintan, Elizabeth Chow-Tung, Alan Eppel, Khrista Boylan

J Can Acad Child Adolesc Psychiatry. 2017 Jul; 26(2): 98–103

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510938/

 

■ Sleep-disordered breathing in patients with newly diagnosed lung cancer

Michael Dreher, Stefan Krüger, Susanne Schulze-Olden et al

BMC Pulm Med. 2018; 18: 72

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956970/

 

■ Cognitive and behavioral interventions to improve sleep in school-age children and adolescentes: a systematic review and meta-analysis

Lie Åslund, Filip Arnberg, Marie Kanstrup, Mats Lekander

J Clin Sleep Med. 2018 Nov 15; 14(11): 1937–1947

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223553/

 

■ Recent advances in treatment for narcolepsy

Lucie Barateau, Yves Dauvilliers

Ther Adv Neurol Disord. 2019; 12: 1756286419875622

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767718/

 

■ The neurobiological basis of narcolepsy

Carrie E. Mahoney, Andrew Cogswell, Igor J. Koralnik, Thomas E. Scammell

Nat Rev Neurosci. 2019 Feb; 20(2): 83–93

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492289/

 

■ Narcolepsy and emotional experience: a review of the literature

1. Schiappa, S. Scarpelli, A. D’Atri, M. Gorgoni, Luigi De Gennaro

Behav Brain Funct. 2018; 14: 19

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305999/

 

■ Genetics of narcolepsy

Taku Miyagawa, Katsushi Tokunag

Hum Genome Var. 2019; 6: 4.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325123/

 

■ Diagnostic criteria, differential diagnosis, and treatment of minor motor activity and less well-known movement disorders of sleep

Ambra Stefani, Birgit Högl

Curr Treat Options Neurol. 2019; 21(1): 1

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339673/

 

■ Sleep disturbances in patients with amyotrophic lateral sclerosis: current perspectives

Matthias Boentert

Nat Sci Sleep. 2019; 11: 97–111

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701267/

 

■ Impact of spinal cord injury on sleep: current perspectives

Abdulghani Sankari, M Safwan Badr, Jennifer L Martin, Najib T Ayas, David J Berlowit

Nat Sci Sleep. 2019; 11: 219–229

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800545/

 

■ Impact of phenotypic herregoeneity of insomnia on the patients´response to cognitive-behavioral therapy for insomnia: current perspectives

Andrea Galbiati, Marco Sforza, Elisabetta Fasiello, Vincenza Castronovo, Luigi Ferini-Strambi

Nat Sci Sleep. 2019; 11: 367–376

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890191/

 

■ Exploring sleep disorders in patients with chronic kidney disease

Gaurav Nigam, Macario Camacho, Edward T Chang, Muhammad Riaz

Nat Sci Sleep. 2018; 10: 35–43

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797456/

 

■ Alteraciones del sueño más frecuentes en las personas en diálisis

Tenorio Cárcamo, Gabriela and Barrios Araya, Silvia

Enferm Nefrol, Dic 2018, vol.21, no.4, p.317-333

http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S2254-28842018000400317&lng=es&nrm=iso

 

■ Sleep disturbances in women with polycystic ovary syndrome: prevalence, pathophysiology, impact and management strategies

Renae C Fernandez, Vivienne M Moore, Emer M Van Ryswyk et al

Nat Sci Sleep. 2018; 10: 45–64.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799701/

 

■ Sleep problems during the menopausal transition: prevalence, impact, and management challenges

Fiona C Baker, Massimiliano de Zambotti, Ian M Colrain, Bei Bei

Nat Sci Sleep. 2018; 10: 73–95

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810528/

 

■ Sleep-related hypermotor epilepsy: prevalence, impact and management strategies

Veronica Menghi, Francesca Bisulli, Paolo Tinuper, Lino Nobili

Nat Sci Sleep. 2018; 10: 317–326

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186898/

 

■ Impact of traumatic brain injury on sleep: an overview

Raissa Aoun, Himanshu Rawal, Hrayr Attarian, Ashima Sahni

Nat Sci Sleep. 2019; 11: 131–14

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707934/

 

■ An update on dual orexin receptor antagonists and their potential role in insomnia therapeutics

Kayla Janto, J. Roxanne Prichard, Snigdha Pusalavidyasaga

J Clin Sleep Med. 2018 Aug 15; 14(8): 1399–1408

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086961/

 

■ Hypnosis interventions effects on sleep outcomes: a systemic review

Irina Chamine, Rachel Atchley, Barry S. Oke

J Clin Sleep Med. 2018 Feb 15; 14(2): 271–283

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786848/

 

■ Workplace interventions to promote sleep health and na alert, healthy workforce

Nancy S. Redeker, Claire C. Caruso, Sarah D. Hashmi, et al

J Clin Sleep Med. 2019 Apr 15; 15(4): 649–657

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457507/

 

■ The value of digital insomnia therapeutics: What we know and what we need to know

Emerson M. Wickwire

J Clin Sleep Med. 2019 Jan 15; 15(1): 11–13

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329555/

 

■ A review of the relationship between emotional learning and memory, sleep, and PTSD

Peter J. Colvonen, Laura D. Straus, Dean Acheson, Philip Gehrman

Curr Psychiatry Rep. 2019 Jan 19; 21(1): 2

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6645393/

 

■ Insomnia disorder in adolescence: diagnosis, impact and treatment

Massimiliano de Zambotti, Aimee Goldstone, Ian M Colrain, Fiona C Baker

Sleep Med Rev. 2018 Jun; 39: 12–24

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931364/

 

■ Sleep and cognitive aging in the eighth decade of life

Simon R Cox, Stuart J Ritchie, Mike Allerhand et al

Sleep. 2019 Apr; 42(4): zsz019

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448287/

 

■ Sleep and cognition in the older adult

Joseph M. Dzierzewski, Natalie Dautovich, Scott Ravyts

Sleep Med Clin. 2018 Mar; 13(1): 93–106

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841581/

 

■ Insomnia in the elderly: a review

Dhaval Patel, Joel Steinberg, Pragnesh Patel

J Clin Sleep Med. 2018 Jun 15; 14(6): 1017–1024

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991956/

 

■ Auriculotherapy for sleep quality in people with primary insomnia: a protocol for a systematic review and meta-analysis

Runyuan Ren, Jiayuan Zhang, Tingting Zhang et al

Medicine (Baltimore) 2019 Feb; 98(8): e14621

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408129/

 

■ Effectiveness and safety of acupuncture for insomnia: protocol for a systematic review

Mingming Zhang, Jingwei Zhao, Xiao Li et al

Medicine (Baltimore) 2019 Nov; 98(45): e17842

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855569/

 

■ Acupuncture using pattern-identification for the treament of insomnia disorder: a systematic review and meta-analysis of randomized controlled trials

Sang-Ho Kim, Jin-Hyung Jeong, Jung-Hwa Lim, Bo-Kyung Kim

Integr Med Res. 2019 Sep; 8(3): 216–226

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718809/

 

■ Medicina do Sono: Mednews Online (Sleep Medicine: Mednews)

https://internetmedica.com.br/medicina-do-sono-mednews-online-sleep-medicine-mednews/

 

■ Medicina do Sono: Organizações Médicas Online (Sleep Medicine: Medical Organizations)

https://internetmedica.com.br/medicina-do-sono-organizacos-medicas-online-sleep-medicine-medical-organizations/

 

■ Apneia Obstrutiva do Sono & Risco Cardiovascular Online (Obstructive Sleep Apnea & Cardiovascular Risk)

https://internetmedica.com.br/apneia-obstrutiva-do-sono-risco-cardiovascular-online-obstructive-sleep-apnea-cardiovascular-risk/

 

■ Síndrome das Pernas Inquietas Online (Restless Legs Syndrome)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186898/

 

■ Harmonizing work with the treatment and prevention of sleep disordered breathing in commertial motor vehicle drivers: implications for health and productivity management

H Wada, M Kimura, R Shirahama et al

Ind Health 2019, vol 57 (1): 3-9

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363577/

 

■ Sleep problems and workplace violence: a systematic review and meta-analysis

Nicola Magnavita, Enrico Di Stasio, Ilaria Capitanelli et al

Front Neurosci. 2019; 13: 997.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779772/

 

■  Dr Paulo Fernando Leite

Cardiologia/Prevenção Cardiovascular

Estratificação de Risco Cardiovascular

Consultório: Rua Padre Rolim 815/sala 601

Tel: 33245518

CRMMG: 7026

Email: pfleite1873@gmail.com