Disbiose: termo largamente utilizado para nomear o desequilíbrio da microbiota intestinal
Prebióticos: são definidos como ingredientes alimentares não digeríveis que afetam beneficamente o hospedeiro ao estimular seletivamente o crescimento e / ou atividade de uma ou de um número limitado de bactérias no cólon. Os prebióticos são substratos alimentares pertencentes ao grupo das fibras que não apresentam digestão completa, afetando de forma benéfica o hospedeiro através da fermentação que ocorre por bactérias intestinais propiciando proteção ao colón.
Probióticos: segundo a Food and Agriculture Organization e World Health os probióticos podem ser definidos como “microrganismos vivos que, quando administrados em quantidade adequada, conferem benefício para a saúde do consumidor”. As bactérias probióticas usadas em produtos comerciais são majoritariamente membros dos gêneros Lactobacillus e Bifidobacterium
Simbióticos: são alimentos ou suplementos que contêm probióticos e prebióticos. A ingestão dessas substâncias é corroborada por alguns achados que indicam sua capacidade de promover a estimulação seletiva da microbiota intestinal do hospedeiro e sua atividade, reduzindo a atrofia celular, diminuindo a permeabilidade intestinal pelo fortalecimento das junções fechadas e, como conseqüências finais, promovendo melhorias no intestino função e estado inflamatório
■ Effects of synbiotic supplementation on gut functioning and systemic inflammation of community-dwelling elders – secondary analyses from a randomized clinical trial
Valentini Neto, João et al
Arq. Gastroenterol., Feb 2020, vol.57, no.1, p.24-30
https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032020000100024&lng=en&nrm=iso&tlng=en
■ The International Scientific for Probiotic and Prebiotics (ISAPP) consensus statement on the definiton and scope of synbiotics
K S Swanson, G R Gibson, R Hutkins et al
Nat Rev Gastroenterol Hepatol 2020, vol 17 (11): 687-701
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581511/
■ Probiotics: versatile bioactive componentes in promoting human health
J Sharifi-Rad, C F Rodrigues, Z Stojanovic-Radic et al
Medicina (Kaunas) 2020, vol 56 (9): 433
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560221/
■ Probiotics in Medicine: a long debate
E Stavropoulos, E Bezirtzoglou
Front Immunol 2020, vol 11: 2192
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544950/
■ Impacto terapêutico dos probióticos na doença hepática gordurosa não alcoólica em pediatria: uma revisão sistemática
Chaves, Felipe Galvão Batista et al
Rev. paul. pediatr., 2021, vol.39
https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822021000100423&lng=en&nrm=iso&tlng=pt (portuguese)
https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822021000100423 (english)
■ Microbiota intestinal e emprego dos probióticos na constipação intestinal em crianças e adolescentes: revisão sistemática
Gomes, Daiane Oliveira Vale San , Morais, Mauro Batista de
Rev paul. Pediatr.; 2020, vol 38
https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822020000100502&lng=en&nrm=iso&tlng=pt (portuguese)
https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822020000100502&lng=en&nrm=iso&tlng=en (english)
■ Probiotics use for antibiotic-associated diarrhea: a pragmatic participatory evaluation in nursing homes
H A van Wietmarschen, M Busch, A van Oostween et al
BMC Gastroenterol 2020, vol 20: 151
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222499/
■ Effects of synviotic supplementation on gut functioning and systemic inflammation of Community-dwelling elders – secondary analysis from a randomized clinical trial
Valentini Neto, João et al
Arq. Gastroenterol., Feb 2020, vol.57, no.1, p.24-30
https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032020000100024&lng=pt&nrm=iso&tlng=en
■ The effect of synbiotics supplementation on anthropometric indicators and lipid profiles in women with polycystic ovary syndrome: a randomized controlled trial
E Karimi, J Heshmati, N Shirzad et al
Lipids Health Dis 2020, vol 19: 60
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132870/
■ Probiotics, prebiotics, synbiotics and paraprobiotics as a therapeutic alternative for intestinal mucosistis
V L Batista, T F da Silva, L C L de Jesus et al
Front Microbiol 2020, vol 11: 544490
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527409/
■ Health professionals´knowledge of probiotics: an international survey
S Fijan, A Frauwallner, L Varga et al
Int J Environ Res Public Health 2019, vol 16 (17): 3128
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747149/
■ Probiotics for the prevention of pediatric antibiotic-associated diarrhea
Q Guo, J Z Goldenberg, C Humphrey, R El Dib et al
Cochrane Database Syst Rev 2019, 2019 (4): CD002427
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6490796/
■ International Society of Sports Nutrition: Probiotics
R Jäger, A E Mohr, K C Carpenter et al
J Int Soc Sports Nutr 2019, vol 16: 62
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925426/
■ Prebiotics for the prevention of hyperbilirubinaemia in neonates
A M Armanian, S Jahanfar, A Feizi et al
Cochrane Database Syst Ver 2019, vol 8: CD012731
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699678/
■ Suplementação com probióticos e depressão: estratégia terapêutica?
A L Ferreira de Moraes, R G A Leite, M Fuentes-Rojas, A E Costa
Rev Ciênc Méd 2019, vol 28 (1): 31-47
https://docs.bvsalud.org/biblioref/2020/01/1047803/med-4-00_4455.pdf
■ Systematic review: probiotics in the management of lower gastrointestinal symptoms – an update evidence-based international consensus
A P S Hungin, C R Mitchell, P Whorwell et al
Aliment Pharmacol Ther 2018, vol 47 (8): 1054-1070
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900870/
■ Probiotics, prebiotics and synbiotics for chronic kidney disease: protocol for a systematic review and meta-analysis
M Pei, L Wei, S Hu et al
BMJ Open 2018, vol 8 (7): e020863
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067341/
■ Prebiotics, bone and mineral metabolism
C M Whisner, L F Castillo
Calcif Tissue Int. 2018, vol 102 (4): 443-447
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851694/
■ Biological activities of lactose-based prebiotics and symbiosis with probiotics on controlling osteoporosis, blood-lipid and glucose levels
A Nath, M A Molnár, A Csighy et al
Medicina (Kaunas) 2018, vol 54 (6): 98
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306850/
■ Implications of probiotics on the maternal-neonatal interface: gut microbiota, immunomodulation, and autoimmunity
B Swartwout, X M Luo
Front Immunol 2018, vol 9: 2840
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286978/
■ Biological activities of lactose-derived prebiotics and symbiotic with probiotics on gastrointestinal system
A Nath, G Haktanirlar, À Varga et al
Medicina (Kaunas) 2018, vol 54 (2): 18
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037253/
■ Probiotics for gastrointestinal disordes: proposed recommendations for children of the Asia-Pacific region
D Cameron, Q S Hock, M Kadim et al
World J Gastroenterol 2017, vol 23 (45): 7952-7964
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725290/
■ Ação de prebióticos e probióticos em indivíduos com câncer colorretal: revisão integrativa
K L Zene, K C Michalichen, L Molinari et al
Revista Uningá Review 2017, vol 29 (3)
http://revista.uninga.br/index.php/uningareviews/article/view/1983/1578
■ Probiotics for the prevention of Clostridium-difficile-associated diarrhea in adults and children
J Z Goldenberg, C Yap, L Lytvyn et al
Cochrane Database Syst Rev 2017, 2017 (12): CD006095
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486212/
■ Prebiotics: why definitons matter
R W Hutkins, J A Krumbeck, L B Bindels et al
Curr Opin Biotecnol 2016, vol 37: 1-7
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744122/
■ Probiotic and synbiotic therapy in critical illness: a systematic rview and meta-analysis
W Manzanares, M Lemieux, P L Langlois, P E Wischmeyer
Crit Care 2016, vol 2: 262
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991010/
■ Synbiotics and gastrointestinal function-related quality of life after elective colorectal cancer resection
G E Theodoropoulos, N A Memos, K Peitsidou et al
Ann Gastroenterol 2016, vol 29 (1): 56-62
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700848/
■ Probiotics, prebiotics, and synbiotics for the prevention of necrotizing enterocolitis
K C Jonhson-Henry, T R Abrahamsson, R Y Wu, P M Sherman
Adv Nutr 2016, vol 7 (5): 928-93
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015037/
■ The use of probiotics in Pediatric Gastroenterology: a review of the literature and recommendations by Latin-American experts
S Cruchet, R Furnes, A Maruy et al
Paediatr Drugs 2015, vol 17 (3): 199-21
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454830/
■ Dr Paulo Fernando Leite
Cardiologia/Prevenção Cardiovascular
Estratificação de Risco Cardiovascular
Consultório: Rua Padre Rolim 815/sala 601
Tel: 33245518
CRMMG: 7026
Email: pfleite1873@gmail.com
Data: novembro 2020
