Eosinofilia: Casos Clínicos (Eosinophilia: Case Reports)
■ Eosinofilia & Lupus Eritematoso Sistêmico (Eosinophilia & Systemic Lupus Erythematosus)
– Eosinophilia can be caused by various conditions, parasitic infection being the most common cause.
– Eosinophilia in the absence of coexisting allergy or parasitic infection is rarely seen in SLE patients.
– Eosinophilia with multiple organ/system involvement suggests eosinophilic granulomatosis with polyangiitis (Churg-Strauss vasculitis) as the primary working diagnosis.
Several reports have described eosinophilic vasculitis, eosinophilic gastroenteritis, Loffler’s endocarditis, eosinophilic pruritic cutaneous lesions, and nonerosive arthritis in patients with systemic lupus erythematosus.
■ An unusual case of eosinophilia with systemic lúpus erythematosus: a case report and review of literature
A Mishra, S Kuikel, R Rauniyar et al
Case Rep Med 2022; 2022: 3264002
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901357/
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■ Síndrome Hipereosinofílica (Hypereosinophilic Syndrome)
– Hypereosinophilic syndrome (HES) is an idiopathic, less defined, less known, primary leuco-proliferative disorder associated with peripheral blood eosinophilia and organ damage
– The old definition (1975) included persistent blood eosinophilia ≥ 1.5 × 109/L lasting for > 6 mo, associated with eosinophil-mediated organ damage. However, the new definition (2010) includes more than peripheral blood eosinophilia or duration of symptoms, and the evidence of eosinophil-mediated organ damage is enough for diagnosis of HES.
– The wide spectrum of atypical manifestations of hypereosinophilic syndrome.
– Eosinophilic gastrointestinal disorder can present with involvement of all three layers of the gastrointestinal tract.
– Hypereosinophilic syndrome can also present with splinter hemorrhages. Prompt management of this lethal infiltrative disease provides a cure and avoids organ complications.
■ Hypereosinophilic syndrome presenting as eosinophilic gastroenteritis disorder and splinter hemorrhages: a case report
A Bhasi, I Patnaik, P K Panda, A Singh
World J Gastrointest Pharmacol Ther 2022, vol 13 (2): 23-29
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968508/
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■ Eosinofilia & Doenças Pulmonares (Eosinophilia & Lung Diseases)
– Eosinophilia with pulmonary involvement is characterized by the presence of peripheral blood eosinophilia, typically ≥500 cells/mm3, by pulmonary symptoms and physical examination findings that are nonspecific, and by radiographic evidence of pulmonary disease and is further supported by histopathologic evidence of tissue eosinophilia in a lung or pleura biopsy specimen and/or increased eosinophils in BAL fluid, usually >10%.
– Eosinophilia with pulmonary involvement may be associated with diverse causes: eosinophilic granulomatosis with polyangiitis, granulomatosis with polyangiiitis, microscopic polyangiitis, hyperreosinophilic syndromes, aspirin-exacerbated respiratory disease, chronic eosinophilic pneumonia, acute eosinophilic pneumonia, eosinophilic bronchitis, allergic bronchopulmonary aspergillosis, helminthic infectious, strongyloidiasis, schistosomiasis, fascioliasis, echinococcosis, cocciddioidomycosis, toxocariasis, mycobacterial infections and HIV
– When an underlying cause is not easily attributable, management of eosinophilia with pulmonary involvement largely relies on eosinophil-directed interventions, for which biologic therapies are increasingly being used.
■ Aproach to eosinophilia presenting with pulmonar symptoms
C E Rosenberg, P Khoury
Chest 2021, vol 159 (2): 507-516
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039005/
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■ Eosinofilia (Eosinophilia)
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Maio 2022