Blog - INTERNET MÉDICA

Cardiopatia Carcinóide (Carcinoid Heart Disease)

Por Paulo Leite 15/07/2022

– A síndrome carcinoide pode causar reações desmoplásicas nos tecidos próximos. Quando envolve o coração, causa doença cardíaca carcinoide (DAC) ou síndrome de Hedinger e geralmente envolve as válvulas cardíacas do lado direito, causando insuficiência tricúspide e estenose pulmonar (TIPS) e, eventualmente, levando à insuficiência cardíaca do lado direito.

– As manifestações clínicas são as de valvopatia cardíaca direita e incluem edema periférico, ascite e hepatomegalia pulsátil. A cardiopatia consiste em depósitos de tecido fibroso no endocárdio, nos folhetos valvares, nos átrios e nos ventrículos.

– Seu diagnóstico imediato e tratamento precoce são primordiais, pois a cardiopatia carcinóide está associada ao aumento da morbidade e mortalidade. A cardiopatia carcinóide pode ser encontrada em até 60% dos pacientes com tumores carcinóides metastáticos.

– O manejo de pacientes com cardiopatia carcinóide é complexo, pois tanto a doença maligna sistêmica quanto o envolvimento cardíaco precisam ser abordados.

■ Hedinger syndrome: a rare cardiac manifestation of carcinoid syndrome

Hayk Ghukasyan

Cureus. 2022 Jul; 14(7): e26528

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250807/

■ Ablation of typical atrial flutter as therapeutic c omponent in carcinoid heart disease: a case report

Susann Groschke, Rolf Weinert, Björn Beckeret al

J Med Case Rep. 2022; 16: 41

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808965/

■ Elevated serotonina andd NT-proBNP levels predict and detect carcinoid heart disease in a large validation study

Sonja Levy, Aoife B. Kilgallen, Catharina M. Korse et al

Cancers (Basel) 2022 May; 14(10): 2361

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139809/

■ Insuficiência cardíaca por un síndrome carcinóide: un reto diagnóstico. Reporte de caso

L F Durán, K Buitrago-Toro, S Jiménez-Salazar et al

Rev Fac Med 2020, vol 68 (4)

http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-00112020000400644

■ Carcinoid heart disease: How to diagnose and treat in 2020?

Barbara Bober, Marek Saracyn, Maciej Kołodziej et al

Clin Med Insights Cardiol. 2020; 14: 117954682096810

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597558/

■ Multidisciplinary team management of carcinoid heart disease

Richard P Steeds, Vandana Sagar, Shishir Shetty, et al

Endocr Connect. 2019 Dec; 8(12): R184–R199

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933832/

■ Hedinger syndrome: first experience and two-year follow-up in patients with carcinoid heart disese

Mohamed El Gabry, Sharaf-Eldin Shehada, Fanar Mourad, et al

J Thorac Dis. 2019 Aug; 11(8): 3234–3240

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753413/

■ Carcinoid heart disease: review of current knowledge

Pradhum Ram, Jorge L. Penalver, Kevin Bryan U. Lo, Janani Rangaswami, Gregg S. Pressman

Tex Heart Inst J. 2019 Feb; 46(1): 21–27

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378997/

■ The 1,2,3,4 of carcinoid heart disease: comprehensive cardiovascular imaging is the mainstay of complex surgical treatment

Dinu Valentin Balanescu, Teodora Donisan, Juan Lopez-Mattei, et al

Oncol Lett. 2019 May; 17(5): 4126–413

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444330/

■ A case of carcinoid syndrome due to malignant metastatic carcinoid tumor with carcinoid heart disease involving four cardiac valves

Brianna J. Shinn, Laura J. Tafe, Pantila Vanichakarn

Am J Case Rep. 2018; 19: 284–288

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865407/

■ Cases in a series of carcinoid syndrome and carcinoid heart disease

R Matshela Mamotabo

Cardiovasc J Afr. 2018 Jul-Aug; 29(4): e1–e7

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421557/

■ Serial surveillance of carcinoid heart disease: factors associated with echocardiographic progression and mortality

R Dobson, M I Burgess, J W Valle et al

Br J Cancer. 2014 Oct 28; 111(9): 1703–1709

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453728/

■ The association of a panel of biomarkers with the presence and severity of carcinoid heart disease: a cross-sectional study

Rebecca Dobson, Malcolm I. Burgess, Melissa Banks et al

PLoS One. 2013; 8(9): e73679

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771983/

■ Síndrome carcinóide (Carcinoid Syndrome)

Arquivos Blog Internet Médica – janeiro 2019

https://internetmedica.com.br/sindrome-carcinoide-online-carcinoid-syndrome/

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■ Médico Responsável: Dr Paulo Fernando Leite

CRMMG: 7026

Belo Horizonte/MG/Brasil

Email: pfleite1873@gmail.com

Julho 2022

Câncer Gástrico: Artigos de Revisão (Stomach Cancer: Reviews)

Por Paulo Leite 14/07/2022

– Dentre os cânceres, o câncer gástrico é uma das principais neoplasias malignas do mundo e ocupa a quinta posição em relação à incidência e a terceira em relação ao índice de mortalidade. No Brasil, é o quarto em incidência nos homens e o sexto nas mulheres

-O tipo histológico mais comum (mais de 90% dos casos) é o adenocarcinoma. Linfomas gástricos, sarcomas e GIST (tumor estromal gastrointestinal), tumores neuroendócrinos e outros mais raros apresentam diferentes potenciais evolutivos e tratamentos. Os tumores gástricos são predominantemente malignos, e aproximadamente 90% a 95% são adenocarcinomas.

– São observados também com menor frequência linfomas, especialmente linfomas não Hodgkin tipo MALT (linfomas associados à mucosa), e os sarcomas, como o leiomiossarcoma.

– A maioria dos tumores estromais gastrointestinais (GIST) foi associada às mutações ativadoras no gene C-kit.

– As neoplasias gástricas benignas incluem os leiomiomas, os tumores carcinóides e os lipomas

■ Epidemiology of stomach cancer

Milena Ilic, Irena Ilic

World J Gastroenterol. 2022 Mar 28; 28(12): 1187–1203.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968487/

■ Desempenho do escore prognóstico no câncer gástrico

H F Fiqueiredo, R D Da Rosa, L B M Fujimoto et al

Medicina (Ribeirão Preto) 2021, vol 54 (4): e-174590

https://www.revistas.usp.br/rmrp/article/view/174590/180451

■ New developments in gastric neuroendocrine neoplasms

Klaire Exarchou, Nathan A. Stephens, Andrew R. Moore, Nathan R. Howes, D. Mark Pritchard

Curr Oncol Rep. 2022; 24(1): 77–88

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831276/

■ Currents updates and future directions in diagnosis and management of gastroenteropancreatic neuroendocrine neoplasms

Andrew Canakis, Linda S Lee

World J Gastrointest Endosc. 2022 May 16; 14(5): 267–290

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9157694/

■ Therapeutic strategies for gastroenteropancreatic neuroenddocrine neoplasmas: state-of-the-art and future perspectives

Elettra Merola, Andrea Michielan, Umberto Rozzanigo, et al

World J Gastrointest Surg. 2022 Feb 27; 14(2): 78–106

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908345/

■ Gastric neuroendocrine neoplasms and precursor lesions: case reports and literature review

Alina Boeriu, Daniela Dobru, Crina Fofiu, Olga Brusnic, Danusia Onişor, Simona Mocan

Medicine (Baltimore) 2022 Jan 14; 101(2): e28550

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8757942/

■ Real-world challenge for clinicians treating advanced gastroesophageal adenocarcinoma

Mark A. Baxter, Russell D. Petty, Daniel Swinson, Peter S. Hall, Shane O’Hanlon

Int J Oncol. 2021 May; 58(5): 22

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7979263/

■ Multimodal treatment in oligometastatic gastric cancer

M Chevallay, C Wassmer, P Iranmanesh et al

World J Gastrointest Oncol 2022,j vol 14 (2): 434-449

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919006/

■ Dietary factors associated with gastric cancer – a review

N S Richa, G Sageena

Translational Medicine Communication 2022, vol 7 (7)

https://transmedcomms.biomedcentral.com/articles/10.1186/s41231-022-00111-x

■ Korean Gastric Cancer Association – Led Nationwide survey on surgically treatedd gastric cancer in 2019

The Information Committee of the Korean Gastric Cancer Association

J Gastric Cancer 2021, vol 2021, vol 21 (3)

https://jgc-online.org/search.php?where=aview&id=10.5230/jgc.2021.21.e27&code=1100JGC&vmode=FULL

■ Diet and risk of gastric cancer: an umbrela review

Emmanouil Bouras, Konstantinos K. Tsilidis, Marianthi Triggi, et al

Nutrients. 2022 May; 14(9): 1764

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105055/

■ Advances in the surgical management of gastric and gastroesophageal junction cancer

R R Narayan, G A Poultsides

Transl Gastroenterol Hepatol 2021, vol 6: 16

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7724174/

■ Identifying the pre-malignant stomach: from guidelines to practice

Jonathan R. White, Matthew Banks

Transl Gastroenterol Hepatol. 2022; 7: 8

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826400/

■ Shifting sands: the role of radiotherapy for patients with gastric and gastroesophageal adenocarcinoma

E B Ludmir, P Das

Trans Gastroenterol Hepatol 2021, vol 6: 50

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343419/

■ What you alway wanted to know about gastric MALY-lymphoma: a focus on recente developments

M Raderer, B Kiesewetter

Ther Adv Med Oncol 2021, vol 13: 17588359211033825

https://journals.sagepub.com/doi/full/10.1177/17588359211033825

■ Ripretinib in gastrointestinal stromal tumor: the long-awaited step forward

M J Lostes-Bardaji, D García-Illescas, C Valverde, C Serrano

Ther Adv Med Oncol 2021, vol 13: 1758835920986498

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797597/

■ Consenso brasileiro sobre câncer gástrico: diretrizes para o câncer gástrico no Brasil

B Zilberstein, C Malheiros, C Weston et al

ABCD, arq bras. Cir. Ddig 2013, vol 26 (1)

https://www.scielo.br/j/abcd/a/XTdWK8dWcJzgJ3DkNn8y95R/?lang=pt