Blog - INTERNET MÉDICA

Câncer de Próstata: Mednews II (Prostate Cancer: Reviews II)

Por Paulo Leite 19/01/2023

■ Câncer de próstata tem novo tratamento com radioterapia reduzida

Ludmilla Souza! Agência Brasil! São Paulo – novembro 2022

https://agenciabrasil.ebc.com.br/saude/noticia/2022-11/cancer-de-prostata-tem-novo-tratamento-com-radioterapia-reduzida

■ Brasil registrou 44 mortes por câncer de próstata por dia em 2021

Agência Brasil! São Paulo – outubro 2022

https://agenciabrasil.ebc.com.br/saude/noticia/2022-10/brasil-registrou-44-mortes-por-cancer-de-prostata-por-dia-em-2021

■ Brasil deve registrar 215 mil novos casos de câncer de próstata no próximo triênio, aponta o INCA

Snif Doctor – dez 2022

https://snifdoctor.com.br/noticias.php?id=12012

■ U.S. cancer deaths decline overall, but prostate cancer make rebound

Medical X Press – january 2023

https://medicalxpress.com/news/2023-01-cancer-deaths-decline-prostate-cancers.html

■ National prostate cancer trial currently testing therapy based on molecular discovery

Medical X Press – january 2023

https://medicalxpress.com/news/2023-01-national-prostate-cancer-trial-therapy.html

■ Social determinants of health affect racial disparity in prostate cancer mortality

Medical XPress – january 2023

https://medicalxpress.com/news/2023-01-social-health-affect-racial-disparity.html

■ Study uncovers potential therapeutic approach for advanced prostate cancer

Medical X Press – december 2022

https://medicalxpress.com/news/2022-12-uncovers-potential-therapeutic-approach-advanced.html

■ Study finds providers use prostate cancer screening tests, even when provide little value to patients

Medical XPress – january 2023

https://medicalxpress.com/news/2023-01-prostate-cancer-screening-patients.html

■ Genomic testing can identify African American prostate cancer patients wtho have high-risk disease

Moffitt Cancer Center – september 2022

https://www.newswise.com/articles/genomic-testing-can-identify-african-american-prostate-cancer-patients-who-have-high-risk-disease

■ Mayo Clinic researchers identify drug resistance factors for advanced prostate cancer

Mayo Clinic – september 2022

https://www.newswise.com/articles/mayo-clinic-researchers-identify-drug-resistance-factors-for-advanced-prostate-cancer

■ Early prostate cancer can harbor agressive tumor cells

Duke University School of Medicine – january 2022

https://pathology.duke.edu/news/early-prostate-cancers-can-harbor-aggressive-tumor-cells

■ Family history, gene variants put black men at risk for early prostate cancer

Duke University School of Medicine – november 2022

https://medschool.duke.edu/news/family-history-gene-variants-put-black-men-risk-early-prostate-cancer

■ Drug triggers immune cells to attach prostate cancer

Julia Evangelou Strait ! Whasington University of School of Medicine in St Louis – november 2022

https://medicine.wustl.edu/news/drug-triggers-immune-cells-to-attack-prostate-cancer/

■ Prostate cancer: zapping metastatic tumors with radiation improves survival

Health Harvard Blog – november 2022

https://www.health.harvard.edu/blog/prostate-cancer-zapping-metastatic-tumors-with-radiation-improves-survival-202211072843

■ A novel strategy to suppress prostate cancer growth

Baylor College of Medicine News – october 2022

https://www.bcm.edu/news/a-novel-strategy-to-suppress-prostate-cancer-growth

■ What are the chances that prostate cancer will return after surgery?

Health Harvard Blog – january 2023

https://www.health.harvard.edu/blog/what-are-the-chances-that-prostate-cancer-will-return-after-surgery-202301122874

■ Prostate cancer: How long should hormonal therapy last?

Health Harvard Blog – december 2022

https://www.health.harvard.edu/blog/prostate-cancer-how-long-should-hormonal-therapy-last-202212052860

■ Câncer de próstata: Mednews I 2022 (Prostate Cancer: Mednews I 2022)

Arquivos Blog Internet Médica – setembro 2022

https://internetmedica.com.br/cancer-de-prostata-mednews-2022-prostate-cancer-mednews-2022/

■ Câncer de Próstata: Artigos de Revisão II (Prostate Cancer: Reviews II)

Arquivos Blog Internet Médica – outubro 2021

https://internetmedica.com.br/cancer-de-prostata-artigos-de-revisao-ii-prostate-cancer-reviews-ii/

■ Câncer de Próstata: Artigos de Revisão I (Prostate Cancer: Reviews I)

Arquivos Blog Internet Médica – outubro 2019

https://internetmedica.com.br/cancer-de-prostata-artigos-de-revisao-online-prostate-cancer-reviews/

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■ Médico Responsável: Dr Paulo Fernando Leite

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Belo Horizonte/MG/Brasil

Email: pfleite1873@gmail.com

Janeiro 2023

Tumor Estromal Gastrointestinal (Gastrointestinal Stromal Tumor – GISTs)

Por Paulo Leite 17/01/2023

O Tumor estromal gastrointestinal (Gastrointestinal stromal tumor – GIST) é a neoplasia mesenquimal mais comum do trato digestivo, possui comportamento biológico variado e a principal forma de tratamento é a ressecção cirúrgica.

– Tumores Estromais Gastrointestinais (GISTs) são raros tumores do trato gastrointestinal. No mundo, apresenta incidência 1,5 a 1/100.000/ano e, no Brasil, estima-se que existam 1.800 novos casos a cada ano. Apresenta maior frequência entre a faixa etária de 60 a 65 anos e localização mais comum no estômago (40-70%), seguido do intestino delgado (20-40%), do colo/reto (5%) e do esôfago (5%). A localização do tumor influencia o seu comportamento biológico, sendo os tumores gástricos os que apresentam melhor prognóstico que os outros sítios cometidos.

– Seu diagnóstico é baseado no quadro clínico, nas características morfológicas, mas, sobretudo, pela presença da proteína c-KIT (CD117) detectada por método imunoistoquímico. Na maioria das vezes, são assintomáticos, descobertos incidentalmente por exames de imagem.

– Os fatores prognósticos mais importantes são o tamanho do tumor e o índice mitótico.

– A ressecção cirúrgica é a terapia de escolha e o quimioterápico mesilato de imatinibe, que está indicado nos casos de irressecabilidade ou doença metastática.

■ Laparoscopic versus open surgery in gastric gastrointestinal stromal tumors larger than 5 cm: a systematic review and meta-analysis

F A Pita Araújo, V N N Lopes, J P C V L Barbosa et al

ABCD arq. Bras. Cir. Dig 2023, vol 35

https://www.scielo.br/j/abcd/a/qYnRzYQWy8K8JSfPpvGytmD/

■ Gastrointestinal stromal tumor: outcomes of the past decade in a reference institution in Southern Brazil

E M Everling, D Marchet, N Marchet De-Antoni et al

ABCD, arq bras cir. Dig 2022 (35)

https://www.scielo.br/j/abcd/a/7BbYtjy4bMZCGCJ7MQWGRTP/citation/?lang=en

■ Gastrointestinal stromal tumors: a comprehensive radiological review

Akitoshi Inoue, Shinichi Ota, Michio Yamasaki, et al

Jpn J Radiol. 2022; 40(11): 1105–1120

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616766/

■ Diagnosing gastrointestinal stromal tumors: the utility of fine-needle aspiration cytology versus biopsy

Yifan Zhang, Sara Renberg, Andri Papakonstantinou, et al

Cancer Med. 2022 Jul; 11(14): 2729–2734

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9302265/

■ Treatment of gastrointestinal stromal tumors (GISTs): a focus on younger patients

Monika Dudzisz-Śledź, Anna Klimczak, Elżbieta Bylina, Piotr Rutkowski

Cancers (Basel) 2022 Jun; 14(12): 2831

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221273/

■ Latest advances in the management of pediatric gastrointestinal stromal tumors

Marta Andrzejewska, Jakub Czarny, Katarzyna Derwich

Cancers (Basel) 2022 Oct; 14(20): 498

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599787/

■ The role of neoadjuvant imatinib in gastrointestinal stromal tumor patients: 20 years of experience from a tertial referral center

Sara Renberg, Yifan Zhang, Fredrik Karlsson et al

Int J Cancer. 2022 Sep 15; 151(6): 906–913

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545454/

■ The GIST of advances in treatment of advanced gastrointestinal stromal tumor

Inga-Marie Schaefer, Ronald P. DeMatteo, César Serrano

Am Soc Clin Oncol Educ Book. 2022 Apr; 42: 1–15

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113521/