¨O tremor essencial (TE) é o mais comum entre os transtornos do movimento. Ele é muito mais comum do que a doença de Parkinson. Tem sido descrito como postural, cinético e até como um tremor esporádico em repouso. Geralmente é bilateral, está presente com diferentes tarefas e interfere nas atividades da vida diária. Embora o tremor essencial possa se manifestar no início da vida adulta, a maioria dos pacientes não apresenta tratamento até 60 anos. Após 69 anos de idade tende a progredir lentamente.  Uma história de tremor aparentemente autossômica dominante é com frequência observada no TE. O tremor envolvendo a cabeça é mais típico de TE. Em geral, o TE é um achado isolado de tremor, enquanto a doença de Parkinson está associada a uma postura inclinada, marcha arrastada e perda de memória. Diferente da doença de Parkinson, o TE não leva a complicações graves. O tremor essencial frequentemente melhora com doses baixas de álcool. A base do tratamento do tremor essencial são os betabloqueadores ou a primidona. Casos grave de TE podem necessitar cirurgia, como a colocação de um estimulador cerebral profundo.¨

 

Consensus statement on the classification of tremors. From the Task Force on Tremor of the International Parkinson and Movement Disorder Society

Kailash P. Bhatia, Peter Bain, Nin Bajaj, et al

Tremor Task Force of the International Parkinson and Movement Disorder Society

Mov Disord. 2018 Jan; 33(1): 75–87

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530552/

 

Tremor: sorting through the differential diagnosis

P Crawford, E E Zimmerman,

Am Fam Physician 2018, vol 97 (3): 180-186

https://www.aafp.org/afp/2018/0201/p180.html

 

Genetic testing preference of individuals in families with essential tremor

Kelly V. Naranjo, Jemin Park, Karen P. Chen et al

Tremor Other Hyperkinet Mov (N Y) 2018; 8: 545

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876471/

 

Essential tremor

L N Clark, E D Louis

Handb Clin Neurol 2018, vol 147: 229-239

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898616/

 

Essential tremor and Parkinson´s disease: exploring the relationship

Arjun Tarakad, Joseph Jankovic

Tremor Other Hyperkinet Mov (N Y) 2018; 8: 589

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329774/

 

Etiologic links betweens environmental and lifestyle factor and essential tremor

Yi‐Lin Ong, Xiao Deng, Eng‐King Tan

Ann Clin Transl Neurol. 2019 May; 6(5): 979–989

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529929/

 

Conditions associated with essential tremor in veterans: a potential role for chronic stress

Adrian Handforth, Gail A. Parker

Tremor Other Hyperkinet Mov (N Y) 2018; 8: 517

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026277/

 

Transient, isolated head tremor in ¨unaffected¨ individuals: Is essential tremor and even more prevalent disease than we suppose?

Elan D. Louis, James H. Meyers, Ashley D. Cristal et al

Front Neurol. 2018; 9: 57

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053923/

 

Magnetic resonance-guided focused ultrasound neurosurgery for essential tremor: A Health Technology Assessment

Health Quality Ontario

Ont Health Technol Assess Ser. 2018; 18(4): 1–141

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963668/

 

Diffusion MRI tractography for improved transcranial MRI-guided focused ultrasound thalamotomy targenting for essential tremo

Qiyuan Tian, Max Wintermark, W. Jeffrey Elias et al

Neuroimage Clin. 2018; 19: 572–580

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029558/

 

The potential value of probabilistic tractography-based for MR-guided focused ultrasound thalamotomy for essential tremor

Evangelia Tsolaki, Angela Downes, William Speier et al

Neuroimage Clin. 2018; 17: 1019–1027

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842733/

 

A widespread visually-sensitive functionalnetwork relates to symptoms in essential tremor

Derek B Archer, Stephen A Coombes, Winston T Chu et al

Brain. 2018 Feb; 141(2): 472–485

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815566/

 

Could wearable and mobile technology improve the management of essential tremor?

Jean-Francois Daneault

Front Neurol. 2018; 9: 257

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916972/

 

Differential diagnosis between Parkinson´s disease and essential tremor using the smartphone´s accelerometer

Sergi Barrantes, Antonio J. Sánchez Egea, Hernán A. González Rojas et al

PLoS One. 2017; 12(8): e018384

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571972/

 

Emerging strategies in the management of essential tremor

Peter Hedera

Ther Adv Neurol Disord. 2017 Feb; 10(2): 137–148

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367648/

 

Intermittent cortical involvement in the preservation of tremor in essential tremor

Sarvi Sharifi, Frauke Luft, Rens Verhagen et al

J Neurophysiol. 2017 Nov 1; 118(5): 2628–2635

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672541/

 

Cerebellar pathology in early onset and late onset essential tremor

Sheng-Han Kuo, Jie Wang, William J. Tate et al

Cerebellum. 2017 Apr; 16(2): 473–482

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336493/

 

Does non-invasive brain stimulation reduce essencial tremor? A systematic review and meta-analysis

Nyeonju Kang, James H. Cauraugh

PLoS One. 2017; 12(9): e0185462.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619788/

 

The differentiated networks related to essential tremor onset and its amplitude modulations after alcohol intake

David J. Pedrosa, Christian Nelles, Peter Brown et al

Exp Neurol. 2017 Nov; 297: 50–61

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584663/

 

Familial aggregation of the cerebellar signs in familial essential tremor

Elan D. Louis, Nora Hernandez, Karen P. Chen et al

Tremor Other Hyperkinet Mov (N Y) 2017; 7: 439

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288993/

 

Psychological sufferering in essential tremor: a study of patients and those who are close to them

Joan K. Monin, Jesús Gutierrez, Sarah Kellner et a

Tremor Other Hyperkinet Mov (N Y) 2017; 7: 526

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740226/

 

Is there a premotor phase of essential tremor

Abhishek Lenka, Julian Benito-León, Elan D. Louis

Tremor Other Hyperkinet Mov (N Y) 2017; 7: 498

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633681/

 

The olivary hypothesis of essential tremor: Time to lay this model to rest?

Elan D. Louis, Abhishek Lenka

Tremor Other Hyperkinet Mov (N Y) 2017; 7: 473

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618117/

 

Non-invasive brain stimulation for essential tremor

Ludy C. Shih, Alvaro Pascual-Leone

Tremor Other Hyperkinet Mov (N Y) 2017; 7: 458. Published online 2017 Mar 28. doi: 10.7916/D8G44W01

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374545/

 

Physical therapy for a patient with essential tremor and prolonged deep brain stimulation: a case report

Elizabeth A. Ulanowski, Megan M. Danzl, Kara M. Sims

Tremor Other Hyperkinet Mov (N Y) 2017; 7: 448

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357321/

 

Digitizing tablet and Fahn-Tolosa-Marin rating of Archimedes spirals have compared minimum detectable change in essential tremor

Rodger J Elble, Aaron Ellenbogen

Tremor Other Hyperkinet Mov (N Y) 2017; 7: 481

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618112/

 

Essential pitfalls in ¨essential¨ tremor

AJ Espay, AE Lang, R Erro, A Merola, A Fasano, A Berardelli, KP Bhatia

Mov Disord. 2017 Mar; 32(3): 325–331

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359065/

 

Knowledge gaps and research recommendations for essential tremor

Franziska Hopfner, Dietrich Haubenberger, Wendy R. Galpern et al

Parkinsonism Relat Disord. 2016 Dec; 33: 27–35

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5271603/

 

Non-invasive central and peripheral stimulation: new hope for essential tremor?

Moussa A. Chalah, Jean-Pascal Lefaucheur, Samar S. Ayache

Front Neurosci. 2015; 9: 440.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649015/

 

Movement-related dynamics of corticl oscillations in Parkinson´s disease and essential tremor

Efstathios D. Kondylis, Michael J. Randazzo, Ahmad Alhourani, et al

Brain. 2016 Aug; 139(8): 2211–222

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022700/

 

Head tremor in essential tremor: ¨yes-yes¨, ¨no-no¨, or ¨round and round¨?

Daphne Robakis, Elan D. Loui

Parkinsonism Relat Disord. 2016 Jan; 22: 98–10

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695227/

 

Patients with essential tremor can have manual dexterity and attention deficits with no impairments in other cognitive functions.

Medeiros, Leonardo Mariano Inácio et al.

Arq. Neuro-Psiquiatr., Feb 2016, vol.74, no.2, p.122-12

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000200008&lng=pt&nrm=iso&tlng=en

 

Intrinsic signature of essential tremor in the cerebello-frontal network

Cécile Gallea, Traian Popa, Daniel García-Lorenzo  et al

Brain. 2015 Oct; 138(10): 2920–2933

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747645/

 

Prevalence and correlates of rest tremor in essential tremor: cross-sectional survey of 831 patients across four distinct cohorts

Elan D. Louis, Nora Hernandez, Monika Michalec

Eur J Neurol. 2015 Jun; 22(6): 927–932

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414706/

 

Challenges in essential tremor genetics: Les défis de la génétique du tremblement essential

Lorraine N. Clark, Elan D. Louis

Rev Neurol (Paris). 2015 Jun-Jul; 171(6-7): 466–474

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863985/

 

Tremor in the elderly: essential and aging-related tremor

Günthe Deuschl, Inge Petersen, Delia Lorenz, Kaare Christensen

Mov Disord. 2015 Sep; 30(10): 1327–1334

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779797/

 

Medical treatment of essential tremor

Ali H Rajput, Alex Rajput

J Cent Nerv Syst Dis. 2014; 6: 29–39

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999812/

 

Electrophysiologic characteristics of tremor in Parkinson?s disease and essential tremor

Cichaczewski, Ederson et al.

Arq. Neuro-Psiquiatr., Apr 2014, vol.72, no.4, p.301-306

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000400301&lng=pt&nrm=iso

 

Neuroimaging essential in essential tremor: a systematic review

Sarvi Sharifi, Aart J. Nederveen, Jan Booij, Anne-Fleur van Rootselaar

Neuroimage Clin. 2014; 5: 217–231

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110352/

 

Abnormal climbing fibre-Purkinje cell synaptic conncetions in the essential tremor cerebellum

Chi-Ying Lin, Elan D. Louis, Phyllis L. Faust et al

Brain. 2014 Dec; 137(12): 3149–3159

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240294/

 

¨Essential tremor¨ or ¨the essential tremors¨: Is this one disease or a family of diseases?

Elan D. Louis

Neuroepidemiology. 2014; 42(2): 81–89

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945103/

 

Essential tremor: from bedside to bench and back to bedside

Elan D. Louis

Curr Opin Neurol. 2014 Aug; 27(4): 461–46

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122986/

 

Essential tremor: a neurodegenerative disease?

Julián Benito-León

Tremor Other Hyperkinet Mov (N Y) 2014; 4: 252

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107287/

 

Key issues in essential tremor genetics research: Where are we now and how can we move forward?

Claudia M. Testa

Tremor Other Hyperkinet Mov (N Y) 2013; 3: tre-03-105-1843-

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582856/

 

What is essential tremor?

Rodger J Elble

Curr Neurol Neurosci Rep. 2013 Jun; 13(6): 353

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674100/

 

Differentiation and diagnosis of tremor

P Crawford, E E Zimmerman

Am Fam Physician 2011, vol 83 (6): 697-702

https://www.aafp.org/afp/2011/0315/p697.html

 

Tremor essencial

M A A Leite

Revista HUPE jan/jun 2010

http://revista.hupe.uerj.br/detalhe_artigo.asp?id=147

 

Tremor essencial

A V de Albuquerque

Rev Neurocienc 2010, vol 18 (3): 401-405

http://www.revistaneurociencias.com.br/edicoes/2010/RN1803/377%20revisao.pdf

 

Olfaction and essential tremor

Quagliato, Lucas Barasnevicius et al.

Arq. Neuro-Psiquiatr., Mar 2009, vol.67, no.1, p.21-24

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000100006&lng=pt&nrm=iso

 

The emerging neuropathology of essential tremo

E D Louis, J P G Vonsattel

Mov Disord 2008, vol 23 (2); 174-182

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692583/

 

Vídeos: Essential Tremor

https://www.youtube.com/watch?v=xVRKO-Sz0x4

 

https://www.youtube.com/watch?v=UxZXieU961Q

 

https://www.youtube.com/watch?v=uBPE2-n7Qkw

 

■  Dr Paulo Fernando Leite

Cardiologia/Prevenção Cardiovascular

Estratificação de Risco Cardiovascular

Novo endereço:

Consultório: Rua Padre Rolim 815/sala 815

Tel: 33245518 (Consulta Particular/Unimed)

– Centro Médico Unimed BH/Contagem/Pedro I

Belo Horizonte/MG/Brasil

CRMMG: 7026

Email: pfleite1873@gmail.com