– A síndrome SAPHO (sinovite, acne, pustulose, hiperostose e osteíte) é uma condição autoinflamatória rara que descreve a constelação de manifestações inflamatórias da pele, ossos e articulações que resultam em dificuldade diagnóstica e desafio terapêutico. Seu diagnóstico pode ser confirmado correlacionando os sintomas clínicos com os achados radiológicos. Contudo, é um desafio fazê-lo, uma vez que as manifestações clínicas desta doença são diferentes, sem marcador sorológico confirmatório, e as alterações radiológicas podem ser inespecíficas.

 

■ A case of SAPHO syndrome complicated by uveitis with Good response to both TNF Inhibitor and JAKinib

R Baisya, M Gavali, M Tyagi, P K Devarasetti

Case Rep Rheumatol 2023; 2023: 6201887

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876693/

 

■ SAPHO syndrome complicated by lesions of the central nervous system successfully treated with brodalumab

M Funabiki, M Tahara, S Kondo et al

Case Rep Rheumatol 2023;2023: 6005531

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935794/

 

■ Risankizumab efficacy in synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) remission: a case report on rheumatologic and dermatologic disease manifestation with literature review

Mario Ferraioli, Luigi Fiannacca, Elisabetta Greco, et al

Case Reports Immunol. 2024; 2024: 9076852

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10965285/

 

■ Refractory ulcerative colitis with associated synovitis, acne, pustulosis, hyperostosis, osteitis syndrome successfully treated with tofacitinib

Bryan J. Kim, Anna Thiemann, Brett Dietz, Kendall Beck

ACG Case Rep J. 2024 Apr; 11(4): e01342

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11025703/

 

■ Family aggregation and prevalence of other autoimmune disease in SAPHO syndrome

Chen Li, Hesong Wang, Haixu Jiang, et al

Heliyon. 2023 Nov; 9(11): e21541

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654150/

 

■ Treatment and monitoring of SAPHO syndrome: a systematic review

Sophie W S Li, Eve Roberts, Christian Hedrich

RMD Open. 2023; 9(4): e003688.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10753757/

 

■ SAPHO syndrome: pathogenesis, clinical presentation, imaging, comorbidities and treatment: a review

Hanna Przepiera-Będzak, Marek Brzosko

Postepy Dermatol Alergol. 2021 Dec; 38(6): 937–942

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802951/

 

■ SAPHO syndrome presenting with atlo-epistrophic synovitis and left vocal cord paresis: a challenging diagnosis

Beatrice Maranini, Giovanni Ciancio, Rosa Rinaldi,  et a

Clin Med Insights Arthritis Musculoskelet Disord. 2022; 15: 1179544122111891

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459495/

 

■ Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome presenting with a cervical vertebral fracture: a case report

Allen Nedley, Omar Ramos, Craig Zuppan, Yan C. Wongworawat, Olumide Danisa

N Am Spine Soc J. 2021 Mar; 5: 10005

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820063/

 

■ Clinical manifestation and diagnostic challenge of SAPHO syndrome: a case report

T E B Spanevello, L T Rodrigues, M R Scalcon

Brazilian Journal of Case Reports 2024 vol 4 (4)

https://bjcasereports.com.br/index.php/bjcr/article/view/clinical_manifestation_diagnostic_challenges/clinical_manifestation_diagnostic_challenges

 

■ Desafios no diagnóstico e tratamento de um caso de syndrome SAPHO na infância

P C G da Silva, E F de Oliveira, A V Goldenzon et al

Anais Brasileiros de Dermatologia 2011, vol 86 (4): 46-49

https://www.scielo.br/j/abd/a/3CYNwYZbSRgZzYdmbcJ6cBc/?lang=pt (portuguese)

 

https://www.scielo.br/j/abd/a/3CYNwYZbSRgZzYdmbcJ6cBc/?lang=en (Spanish)

 

■ Do you know this syndrome?

G Dellatorre, C C S de Castro

An Bras. Dermatol 2012, vol 87 (1)

https://www.scielo.br/j/abd/a/ynqmFKVsZfBBPBNYmpBJfmx/?lang=en

 

■ Acesso gratuito

■ Um dos Blog de Medicina mais acessado em todo o mundo. Mais de 1300 temas médicos já disponíveis online

■ Use o mecanismo de busca – PESQUISAR na home page.

■ Acesse ARQUIVO e ePncontre os temas incluídos no Blog a cada mês, desde maio 2017

■ Blog Internet Médica – www.internetmedica.com.br

■ Médico Responsável: Dr Paulo Fernando Leite

CRMMG: 7026

Consultório (Novo Endereço): Rua Rio Grande do Norte 23/ 9 andar

Tels 996346835   32438504

Belo Horizonte/MG/Brasil

Email: pfleite1873@gmail.com

Maio 2024