¨A síndrome de Mounier-Kuhn ou traqueobroncomegalia é uma doença rara, caracterizada por atrofia ou ausência de fibras elásticas e adelgaçamento da musculatura lisa na traqueia, brônquios principais e de primeira à quarta ordem; consequentemente, as vias aéreas flácidas tornam-se bastante alargadas na inspiração e colapsadas na expiração. Os sintomas podem ser variáveis. A doença é caracterizada clinicamente pela presença de infecções respiratórias de repetição, acúmulo de secreção e tosse inefetiva. Observa-se leve predomínio no sexo masculino, na terceira ou quarta décadas de vida, mas a exata prevalência da doença não é conhecida e são poucos os casos relatados na literatura. Acredita-se que a fraqueza do tecido conjuntivo, associada à inalação de poluentes aéreos e fumaça de cigarro, sejam os principais fatores no desenvolvimento desta síndrome. O tratamento geralmente é de suporte ¨
■ Flexible bronchoscopy and mechanical ventilation in managing Mounier-Kuhn syndrome: a case report
Kaya, Aslihan Gürün et al.
Sao Paulo Med. J., May 2018, vol.136, no.3, p.266-269
■ Current concepts in severe adult tracheobronchomalacia: evaluation and treatment
Daniel H. Buitrago, Jennifer L. Wilson, Mihir Parikh et al
J Thorac Dis. 2017 Jan; 9(1): E57–E6
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303067/
■ Mounier-Kuhn syndrome: a case of trachel smooth muscle remodeling
Daniel P. Cook, Ryan J. Adam, Mahmoud H. Abou Alaiwa et al
Clin Case Rep. 2017 Feb; 5(2): 93–96
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290513/
■ Congenital tracheobronchomegaly (Mounieer-Kuhn syndrome) in a woman with human immunodeficiency virus: a case report
Amanda Fletcher, Justin Stowell, Socrates Jamoulis
Cureus. 2017 Apr; 9(4): e1136
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418028/
■ Mounier-Kuhn syndrome in an elderly female with pulmonary fibrosis
P Boglou, N Papanas, A Oikonomou et AL
Case Reports in Medicne 2016, Article ID 8708251, 4 pages
https://www.hindawi.com/journals/crim/2016/8708251/
■ Mounier-Kuhn syndrome: more than just a cough
Christine Azzopardi, Joseph Attard, Edith Vassallo, Reuben Grech
BMJ Case Rep. 2014; 2014: bcr201420615
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166130/
■ Mounier-Kuhn syndrome in an elderly female with pulmonary fibrosis
Panagiotis Boglou, Nikolaos Papanas, Anastasia Oikonomou et al
Case Rep Med. 2016; 2016: 870825
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002455/
■ Traqueobroncomegalia: a propósito de un caso clínico-radiológico
Canales F, Luis et al
Rev. chil. enferm. respir., Jun 2015, vol.31, no.2, p.101-104
https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0717-73482015000200005&lng=es&nrm=iso
■ Mounier-Kuhn syndrome: more than Just a cough
Christine Azzopardi, Joseph Attard, Edith Vassallo, Reuben Grech
BMJ Case Rep. 2014; 2014: bcr201420615
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166130/
■ Mounier-Kuhn syndrome: a rare and often overlooked cause of bronchial dilation and recurrent respiratory tract infections
Kapoor, Shailendra.
- bras. pneumol., Jan 2014, vol.40, no.1, p.96-9
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132014000100096&lng=pt&nrm=iso
■ A delayed diagnosis of Mounier-Kuhn syndrome
Caroline Gouder, David Bilocca, Peter Fsadni, Stephen Montefort
BMJ Case Rep. 2014; 2014: bcr2014203674
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054406/
■ Mounier-Kuhn syndrome. Imaging and bronchoscopic findings
K El-Kersh, M Yasin, R Cavallazzi, R L Perez
AJRCCM 2014, vol 190 (1)
https://www.atsjournals.org/doi/full/10.1164/rccm.201307-1306IM
■ Are airways structural abnormalities more frequent in children with recurrent lower respiratory tract infections?
M Santiago-Burruchaga, R Zalacain-Jorge, C Vazquex-Cordero
Respiratory Medicine 2014, vol 108, vol 5:800-805
https://www.resmedjournal.com/article/S0954-6111(14)00089-4/fulltext
■ Mounier-Kuhn syndrome or congenital tracheobronchomegaly: a literature review
E Krustins, Z Kravale, A Buls
Respiratory Medicine 2013, vol 107 (12): 1822-1828
https://www.resmedjournal.com/article/S0954-6111(13)00361-2/fulltext
■ Infección respiratoria causada por Alcaligenes xylosoxidans en un paciente con síndrome de Mounier-Kuhn
Arroyo-Cózar, Marta et al.
Rev. chil. infectol., Oct 2012, vol.29, no.5, p.570-571
https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-10182012000600019&lng=es&nrm=iso
■ Mounier-Kuhn syndrome: the role of bronchiectasis in clinical presentation
Edson Marchiori, Arthur Sousa Sousa, Jr, Gláucia Zanetti, Bruno Hochhegger
Ann Thorac Med. 2012 Jan-Mar; 7(1): 51
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277044/
■ Mounier-Kuhn syndrome: anesthetic experience
D S Ushakumari, N Grewal, M Green
Case Reports in Anesthesiology 2012, Article ID 674918, 2 pages
https://www.hindawi.com/journals/cria/2012/674918/
■ Mounier-Kuhn syndrome
B Celik, S Bilgin, C Yuksel
Texas Heart Inst J 2011,vol 38 (2):: 194-196
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066798/
■ Síndrome de Mounier-Kuhn: achados radiológicos e apresentação clínica
Bastos, Andréa de Lima and Brito, Isabela Lage Alves
Radiol Bras, Jun 2011, vol.44, no.3, p.198-200
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-39842011000300016&lng=pt&nrm=iso
■ Síndroma de Mounier-Kuhn, uma causa rara de infecções respiratórias de repetição
A Marques, M Félix, F Barata et al
Revista Portuguesa de Pneumologia 2007, vol XIII N.5, set-out2007
http://www.elsevier.pt/en/revistas/revista-portuguesa-pneumologia-320/pdf/S2173511507703664/S300/
■ Pulmonary transplantation in Mounier-Kuhn syndrome: a case report
S S Shah, D Karnak, D Mason et al
Journal of Thoracic and Cardiovascular Surgery 2006, vol 131 (3): 757-758
https://www.jtcvs.org/article/S0022-5223(05)01998-7/fulltext
■ Síndrome de Mounier-Kühn
Fortuna, Fabrício Piccoli et al.
- bras. pneumol., Abr 2006, vol.32, no.2, p.180-183
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132006000200015&lng=pt&nrm=iso
■ Traqueobroncomegalia (síndrome de Mounier-Kuhn): relato de caso e revisão da literatura
Nóbrega, Bruno Barcelos da et al.
Radiol Bras, Jun 2002, vol.35, no.3, p.187-189
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-39842002000300012&lng=pt&nrm=iso
■ by Dr Paulo Fernando Leite
Cardiologia – Centro Médico Unimed BH
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