¨A síndrome de Gradenigo, uma complicação rara de otite média, é caracterizada por otorréia purulenta, paralisia de nervo abducente e dor na área de inervação do nervo trigêmeo. Sua ocorrência está relacionada ao acometimento do ápice da parte petrosa do osso temporal e estruturas vizinhas a essa área. Desde o advento da antibioterapia, passou a ser uma complicação rara da otite média aguda mas potencialmente fatal, requerendo diagnóstico e tratamento precoce. O tratamento para esta afecção constitui grande polêmica na literatura mundial, com muitos autores justificando a intervenção cirúrgica precoce, enquanto outros poucos acreditam que o tratamento conservador consegue reverter os sinais e sintomas desta síndrome e minimizar a ocorrência de seqüelas.¨
■ Gradenigo´s syndrome: a review
M R Gore,
Ann Med Health Sci Res 2018, vol 8: 220-224
https://www.amhsr.org/articles/gradenigos-syndrome-a-review.pdf
■ Gradenigo´s syndrome and labyrinthitis: conservative versus surgical treatment
Ahmad Al-juboori, Amira Nasser Al Hail
Case Rep Otolaryngol. 2018; 2018: 6015385
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091283/
■ Gradenigo´s syndrome in a patient with chronic suppurative otitis media, petrous apicitis, and meningitis
Nicholas Taklalsingh, Franco Falcone, Vinodkumar Velayudhan
Am J Case Rep. 2017; 18: 1039–1043
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629926/
■ Acute otitis media-induced Gradenigo syndrome, a dramatic response to intravenous antibiotic
Tayebeh Kazemi
Iran J Otorhinolaryngol. 2017 May; 29(92): 165–169
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448032/
■ Clivus erosions following Gradenigo´s syndrome-mastoiditis causing VI nerve palsy
Tharsika Karunakaran, Myuran Kaneshamoorthy, Robert Harris
BMJ Case Rep. 2016; 2016: bcr201621460
https://casereports.bmj.com/content/2016/bcr-2016-214604
■ Multidisciplinary care of a paediatric patient with Gradenigo´s syndrome
Noor Janjua, Mohammed Bajalan, Samantha Potter et al
BMJ Case Rep. 2016; 2016: bcr201521433
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769448/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800200/
■ Gradenigo syndrome: unusual consequence of otitis media
Jennie M. Valles, Robert Fekete
Case Rep Neurol. 2014 May-Aug; 6(2): 197–201
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164058/
■ Gradenigo syndrome: an unexpected otitis complication
Catarina, Mendes et al.
Nascer e Crescer, Mar 2014, vol.23, no.1, p.25-28
■ Gradenigo´s syndrome secondary to chronic otitis media on a background of previous radical mastoidectomy: a case report
Yuvatiya Plodpai, Siriporn Hirunpat, Weerawat Kiddee
J Med Case Rep. 2014; 8: 217.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086707/
■ Mastoiditis and Gradenigo´s syndrome with anaerobic bacteria
Chris Ladefoged Jacobsen, Mikkel Attermann Bruhn, Yousef Yavarian, Michael L Gaihede
BMC Ear Nose Throat Disord. 2012; 12: 10
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503843/
■ Conservative management of Gradenigo´s syndrome in a child
Thomas E Rossor, Yvonne C Anderson, Nicholas B Steventon, Lesley M Voss
BMJ Case Rep. 2011; 2011: bcr0320113978
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082063/
■ Gradenigo´s syndrome: beyond the classical triad of diplopia, facial pain and otorrhea
José Luiz Pedroso, Camila Catherine Henriques de Aquino, Agessandro Abrahão et al
Case Rep Neurol. 2011 Jan-Apr; 3(1): 45–47
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072192/
■ Síndrome de Gradenigo: comunicación de un caso
Guedes, Veronica et al
Arch. argent. pediatr., Jun 2010, vol.108, no.3, p.e74-e75
http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0325-00752010000300012&lng=es&nrm=iso
■ Tratamento conservador da síndrome de Gradenigo
Felix, Felippe et al.
Rev. Bras. Otorrinolaringol., Mar 2003, vol.69, no.2, p.256-259
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72992003000200017&lng=pt&nrm=iso
by Dr Paulo Fernando Leite
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