¨A síndrome CREST corresponde à forma limitada da esclerose sistêmica e é caracterizada pelas seguintes alterações: calcinose (C), fenômeno de Raynaud (R), doença esofágica (E), esclerodactilia (S) e telangiectasia (T). Além das alterações dermatológicas características acima mencionadas, os pacientes comumente têm hiperpigmentação, principalmente nas áreas expostas ao sol. A maioria dos pacientes tem anticorpos circulantes contra centrômeros – 80% (ou seja, anticorpos anticentrômeros). Das formas da esclerose sistêmica, a síndrome CREST tem um melhor prognóstico, com uma sobrevida em 10 anos superior a 70%. O envolvimento da pele geralmente é limitado aos dedos das mãos, porções distais dos braços e das pernas e face, e frequentemente começa com o fenômeno de Raynaud. O envolvimento visceral pode incluir doença pulmonar intersticial, hipertensão pulmonar. Estudos subseqüentes demonstraram que embora de evolução clínica lenta, as anormalidades viscerais não são tão raras como se pensava. Alterações pulmonares são freqüentes, principalmente a hipertensão pulmonar. ¨
■ Retinal vasculitis associated with CREST syndrome
Sungjae Yang, Laura J. Kopplin, James T. Rosenbaum
Am J Ophthalmol Case Rep. 2018 Jun; 10: 185–188
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956742/
■ Challenging autopsy finding in a patient with systemic sclerosis with CREST syndrome
A raof A Agha, N Varshney, Z Moussa, V Anandan
American Journal of Clinical Pathology 2018, vol 150 (suppl_1): S58
https://academic.oup.com/ajcp/article/150/suppl_1/S58/5103171
■ Coexistent primary biliary cholangitis with CREST syndrome (Reynolds Syndrome)
A Kivani, S Ursu
American Journal of Medicine2017, vol 130 (11): e501-e502
https://www.amjmed.com/article/S0002-9343(17)30597-1/fulltext
■ Cutaneous calcinosis in a patient with limited scleroderma: CREST syndrome
Nurşen Düzgün
Eur J Rheumatol. 2017 Dec; 4(4): 305–306
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741348/
■ CREST calcinosis affecting the lumbar and cervical spine and the use of minimally-invasive surgery
Kassem Faraj, Kristin Perez-Cruet, Mick Perez-Cruet
Cureus. 2017 Apr; 9(4): e1145
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422109/
■ Assessment and surgical treatment of calcinosis of the shoulder associated with CREST syndrome
- Manohara, S. J. Breusch
Case Rep Rheumatol. 2016; 2016: 9759182
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942620/
■ CREST syndrome- a limited form of systemic scleroderma: a case report and literature review
M Paravina, M Stanojevic, L Spalevic et al
Serbian Journal of Dermatology and Venereology 2016, vol 7 (3): 97-114
https://content.sciendo.com/view/journals/sjdv/7/3/article-p97.xml
■ Assessment and surgical treatment of calcinosis of the shoulder associated with CREST syndrome
R Manohara, S J Breusch
Case Reports in Rheumatology 2016, Article ID 9759182, 4 pages
https://www.hindawi.com/journals/crirh/2016/9759182/
■ Severe digital calcinosis in CREST syndrome
S Anjum, D Howard, P O´Connell
JSM Clin Case Rep 2015, vol 4 (1): 1095
https://www.jscimedcentral.com/CaseReports/casereports-4-1095.php
■ Pulmonary capillary hemangiomatosis associated with CREST syndrome: a case report and review of the literature
F McGuire, T Kennelly, T Tillack, M Robbins
Respiration 2010, vol 80: 435-438
https://www.karger.com/article/FullText/314587
■ Granulomatous uveitis, CREST syndrome, and primary biliary cirrhosis
P Santos, L Olivieira, M Moraes et al
Br J Ophthalmol. 2000 May; 84(5): 546
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1723451/
■ Taxane-induced morphea in a patient with CREST syndrome
Susan M. Bouchard, Melinda R. Mohr, Robert J. Pariser
Dermatol Reports. 2010 Jan 18; 2(1): e9
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211477/
■ Sporadic hemiplegic migraine and CREST syndrome
Martin Pablo Grecco, Miguel Pieroni, Marcela Otero et AL
J Headache Pain. 2010 Apr; 11(2): 171–173
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3452292/
■ Acute central retinal artery occlusion presenting as CREST syndrome
M S A Raja, B J L Burton,
Cases Journal 2009, vol 2: 9
https://link.springer.com/article/10.1186/1757-1626-2-9
■ Adenocarcinoma of the third portion of the duodenum in a man with CREST syndrome
Georgios Anastasopoulos, Athanasios Marinis, Christos Konstantinidis et al
World J Surg Oncol. 2008; 6: 106
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566573/
■ Systemic sclerosis/scleroderma: a treatable multisystem disease
M Hinchcliff, J Varga
Am Fam Physician 2008, vol 78 (8): 961-968
https://www.aafp.org/afp/2008/1015/p961.html
■ Soft-tissue infection and underlying calcinosis of CREST syndrome
Navdeep Tangri, Barbara M. Young
CMAJ. 2006 Oct 24; 175(9): 1059,1061
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1609158/
■ Síndrome de CREST e hipertensão pulmonar – prognóstico sombrio
A C Carneiro, I P Barbosa, F C Chaves
Acta Med Port 2004, vol 17: 409-414
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1103/768
■ Qual o seu diagnóstico?
C M Turtelli, H S L Silva
Radiol Bras 2002, vol 6
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-39842002000600002
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