– A hemoglobinúria paroxística noturna é um distúrbio da medula óssea caracterizado por hemólise intravascular e hemoglobinúria. Leucopenia, trombocitopenia, tromboses arteriais e venosas são comuns.  Ocorre por uma mutação do gene PIG-A, responsável pela síntese de moléculas que ancoram as proteínas CD59 e CD55 à membrana do eritrócito. A ausência dessas proteínas suscetibiliza os eritrócitos à lise pelo sistema do complemento. O diagnóstico requer citometria de fluxo.

 

■ Paroxysmal nocturnal hemoglobinuria in the context of a myeloproliferative neoplasm: a case report and review of the literature

Juri Alessandro Giannotta, Bruno Fattizzo, Wilma Barcellini

Front Oncol.2021; vol 11: 756589

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8632248/

 

■ Hemoglobinúria paroxística noturna: relato de caso clínico com pancitopenia

D R Almeida, L M Cichota, L M Bottega, L V P Silva

Hematology, Transfusion and Cell Therapy 2020, vol 42: S2

http://www.htct.com.br/en-hemoglobinuria-paroxistica-noturna-relato-de-articulo-S2531137920302996

 

■ Relato de caso: hemoglobinúria paroxística noturna

J F L M da Silva, K M N Reis, B A Gandra et al

Revista Científica FAGOC – Saúde 2020, vol 5 (2)

https://revista.unifagoc.edu.br/index.php/saude/article/view/662/608

 

■ Treatment of paroxysmal nocturnal hemoglobinuria in pregnancy with eculizumab: a case report

Michael J. Fassett, Adrian L. Hernandez Lopez

Case Rep Womens Health.2021vol 30: e00294

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7903290/

 

■ Severe hemolysis in a COVID-19 patient with paroxysmal nocturnal hemoglobinuria

Steve Biko Otieno, Alaa Altahan, Fnu Kaweeta et al

Case Rep Hematol.2021; 2021: 6619177

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8285198/

 

■ COVID-19 infection presenting as paroxysmal nocturnal hemoglobinuria

Adam Hines, Nausheen Hakim, Jacqueline Barrientos

Clin Case Rep.2021vol 9(8): e04636

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8380091/

 

■ A case report: paroxysmal nocturnal hemoglobinuria and systemic lupus erythmetosus association

Istemi Serin, Aslıhan Bayir, Hasan Goze, Osman Yokus

Int J Hematol Oncol.2021, vol 10(1): IJH3

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8191648/

 

■ Coombs-positive paroxysmal nocturnal haemoglobinuria

S Kalam, R Beale, D Hughes, et al

Oxf Med Case Report mar 2020

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7104188/

 

■ Prolonged remission of cancer of unknown primary following initiation of eculizumab therapy for paroxysmal nocturnal hemoglobinuria

Ming Y. Lim, Keith E. Volmar, Nigel S. Key

Case Rep Hematol.2019; 2019: 2587597

https://www.hindawi.com/journals/crihem/2019/2587597/

 

■ Autosplenectomy in a patient with paroxysmal nocturnal hemoglobinuria (PNH)

Ethan Burns, Kartik Anand, Gonzalo Acosta et al

Case Rep Hematol.2019; 2019: 3146965

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6390241/

 

■ Hemoglobinuria Paroxística Noturna (Paroxismal Nocturnal Hemoglobinuria)

Arquivos Blog Internet Médica – julho 2018

https://internetmedica.com.br/hemoglobinuria-paroxistica-noturna-online-paroxysmal-nocturnal-hemoglobinuria/

 

■ Dr Paulo Fernando Leite

Cardiologia/Prevenção Cardiovascular

Consultório: Rua Padre Rolim 815/sala 601 – Belo Horizonte/MG/Brasil

Tel: 33245518

CRMMG: 7026

Email: pfleite1873@gmail.com

Blog Internet Médica – www.internetmedica.com.br

Data: dezembro 2021