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■ Epidemiological characteristics of an risk factors for breast cancer in the world
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■ Axillary web syndrome following breast cancer surgery: symptoms, complications, and management strategies
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■ Targeting stem cells in the realm of drug-resistant breast cancer
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■ Stain use and breast cancer survival – a Swedish Nationwide study
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■ Preliminary safety and efficacy of first-line pertuzumab combined with trastuzumab and taxane therapy for HER2-positive locally recurrent or metastatic breast cancer (PERUSE)
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■ BEECH: a dose-finding run-in followed by a randomized phase II study assessing the efficacy of AKT inhibitor capivasertib (AZD5363) combined with paclitaxel in patients with estrogen receptor-positive advanced or metastatic breast cancere, and in PIK3CA mutant sub-population
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■ European cancer mortality predictions for the year 2019 with focus on breast cancer
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■ OlympiAD final overall survival and tolerability results: Olaparibib versus chemotherapy treatment of physician´s choice in patients with a germline BRCA mutation and HER2-negative metastatic breast cancer
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■ Genomic alterations in breast cancer: level of evidence for actionability according to ESMO Scale for Clinical Acionability of molecular Targets (ESCAT)
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■ Association of tumor-infiltrating lymphocytes with distant disease-free survival in the ShorHER randomized adjuvant for patients with early HER2+ breast cancer
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■ Loss of function of NF1 is a mechanism of acquired resistance to endocrine therapy in lobular breast cancer
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■ Nine weeks versus 1 year adjuvant transtuzumab in combination with chemotherapy: final results of the phase III randomized Short-HER study
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■ Letrozole and palbociclib versus chemotherapy as neoadjuvant therapy of hign-risk luminal breast cancer
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■ Mutational mechanism of amplifications revealed by analysis of clustered rearrangements in breast cancers
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■ Breast cancer brain metastases show increased levels of genomic aberration-based homologous recombination deficiency scores relative to their corresponding primary tumors
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■ nab-Paclitaxel plus carboplatin or gemcitabine versus gemcitabine plus carboplatin as first-line treatment of patients with triple-negative metastatic breast cancer: results from the tnAcity trial
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■ Platinum-based neoadjuvant chemotherapy in triple-negative breast cancer: a systematic review and meta-analysis
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■ Updated results from MONALEESA-2, a phase III trial of first-line ribociclib plus letrozole versus placebo plus letrozole in hormone receptor-positive, HER2-negative advanced breast cancer
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■ Randomised phase III trial of vinflunine plus capecitabine versus capecitabine alone in patients with advanced breast cancer previously treated with and anthracycline and resistant to taxane
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■ RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer
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■ Recurrent hyperactive ESR1 fusion proteins in endocrine therapy resistant breast cancer
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■ Open-label randomized phase III trial of vinflunine versus and alkylating agent in patients with heavily pretreated metastatic breast cancer
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■ Impact of palbociclib plus letrozole on patient-reported health-related quality of life: results from the PALOMA-2 trial
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■ Unravelling triple-negative breast cancer molecular hereogeneity using an integrative multiomic analysis
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■ Overexpression of BLM promotes DNA damage and increased sensitivity to platinum salts in triple-negative breast and serous ovarian cancers
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■ Polyclonal RB1 mutations and acquired resistance to CDK 4/6 inhibitors in patients with metastatic breast cancer
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■ Pertuzumab, trastuzumab, and standard anthracycline- and taxane-based chemotherapy for the neoadjuvant treatment of patients with HER2-positive localized breast cancer (BERENICE): a phase II, open-label, multicenter, multinational cardiac safety study
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■ Impact of homologous recombination deficiency biomarkers on outcomes in patients with triple-negative breast cancer treated with adjuvant doxorubicin and cyclophosphamide (SWOG S9313)
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■ A randomized phase II study evaluating different maintenance schedules of nab-paclitaxel in the first-line treatment of metastatic breast cancer: final results of the IBCSG 42-12/BIG 2-12 SNAP trial
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■ Clinical considerations of the role of palbociclib in the management of advanced breast cancer patients with an withut visceral metastases
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■ Tracking evolution of aromatase inhibitor resistance with circulating tumor DNA analysis in metastatic breast cancer
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Annals of Oncology 2018, vol 29 (1): 145-153
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■ Veliparib with temozolomide or carboplatin/paclitaxel versus placebo with carboplatin/paclitaxel in patients with BRCA1/2 locally recurrent/metastatic breast cancer: randomized phase II study
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■ A gene signature to predict high tumor-infiltrating lymphocytes after neoadjuvant chemotherapy and outcome in patients with triple-negative breast cancer
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■ A predictive model of pathologic response based on tumor cellularity and tumor-infiltrating lymphocytes (CelTIL) in HER2-positive breast cancer treated with chemo-free dual HER2 blockade
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■ Ten-year results of intense dose-dense chemotherapy show superior survival compared with a conventional schedule in high-risk primary breast cancer: final results of AGO phase III iddEPC trial
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Annals of Oncology 2018, vol 29 (1): 178-185
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■ Influence of patient and tumor characteristics on early therapy persistence with letrozole in postmenopausal women with early breast cancer: results of the prospective Evaluate-TM study with 3941 patients
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Annals of Oncology 2018, vol 29 (1): 186-192
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■ Dr Paulo Fernando Leite
Cardiologia/Prevenção Cardiovascular
Estratificação de Risco Cardiovascular
Novo endereço:
Consultório: Rua Padre Rolim 815/sala 815
Tel: 33245518 (Consulta Particular/Unimed)
– Centro Médico Unimed BH/Contagem/Pedro I
Belo Horizonte/MG/Brasil
CRMMG: 7026
Email: pfleite1873@gmail.com