¨Criptococose (torulose, blastomicose européia, doença de Busse-Buschke) é micose de natureza sistêmica de porta de entrada inalatória causada por fungos do complexo Cryptococcus neoformans, atualmente com duas espécies: Cryptococcus neoformans e Cryptococcus gattii. Ambas causam meningoencefalite, de evolução grave e fatal, acompanhada ou não, de lesão pulmonar evidente, fungemia e focos secundários para pele, ossos, rins, supra-renal, entre outros. A mortalidade por criptococose é estimada em 10% nos países desenvolvidos chegando a 43% nos paises em desenvolvimento. Cryptococcus neoformans é cosmopolita, ocorre em diversos substratos orgânicos, freqüentemente associa-se a habitat de aves, excretas secas, ricas em fontes de nitrogênio, como uréia e creatinina. Condições favoráveis ao crescimento abundante desta levedura formam microfocos, notadamente em centros urbanos e relacionados a pombos. O ambiente domiciliar, particularmente na poeira doméstica, pode apresentar positividade (50% e 13%). Cryptococcus gattii tem sido isolado do ambiente principalmente em regiões tropicais e subtropicais, mas áreas de clima temperado e frio devem ser incluídas em sua distribuição. A criptococose ocorre como primeira manifestação oportunista em cerca de 4,4% dos casos de aids no Brasil. A criptococose é uma das micoses de mais fácil diagnóstico por apresentar marcado tropismo neurológico, abundância de elementos fúngicos no líquor e nas lesões, presença de cápsula característica, diagnóstico imunológico e coloração tecidual específica. Existem várias formas clínicas e tratamento da criptocosose: comprometimentos pulmonar, neurológico, ósseo, ocular, cutânea, renal, incluindo prostatite criptocóccica.¨

■ Drug development for cryptococcosis treatment: What can patents tell us?

Juliana Santos-Gandelman, Alice Machado-Silva

Mem Inst Oswaldo Cruz. 2019; 114: e180391

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358010/

 

■ Resistance and tolerance to Cryptococal infection: an intricate balance that controls the development of disease

M Shourian, S T Qureshi

Front Immunol jan 2019

https://www.frontiersin.org/articles/10.3389/fimmu.2019.00066/full

 

■ The diagnostic challenge of an infrequent spectrum of Cryptococcus infection

Case Reports in Radiology 2019, Article ID 5970648, 6 pages

https://www.hindawi.com/journals/crira/2019/5970648/

 

■ The status of cryptococcosis in Latin American

Carolina Firacative, Jairo Lizarazo, María Teresa Illnait-Zaragozí et al

Mem Inst Oswaldo Cruz. 2018; 113(7): e170554.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888000/

 

■ The war on cryptococcosis: a review of the antifungal arsenal

A Mourad, J R Perfect

Mem Inst Oswaldo Cruz 2018, vol 113 (7): e17091

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851043/

 

■ Pulmonary cryptococcosis coexisting with adenocarcinoma: a case report and review of the literature

Liyang Li, Liang Zhuang, Jian Zhou, Changzhou Shao

J Med Case Rep. 2018; 12: 327

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214163/

 

■ Disseminated cryptococcosis in Crohn´s disease: a case report

Natthakit Chavapradit, Nasikarn Angkasekwinai

BMC Infect Dis. 2018; 18: 620

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280410/

 

■ Identification of Cryptococcus neoformans by MALDI-TOF mass spectrometry in blood culture

M R B Araújo, Elaine G M Santos, V Wolf, L F Seabra

Clinical & Biomedical Research 2018, vol 38 (2)

https://seer.ufrgs.br/hcpa/article/view/78285/pdf

 

■ Clinical features and radiological characteristics of pulmonary cryptococcosis

Hui Deng, Jie Zhang, Jia Li, Dongxu Wang, Lei Pan, Xinying Xue

J Int Med Res. 2018 Jul; 46(7): 2687–269

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124262/

 

■ Criptococose pulmonar simulando captação neoplásica na PET/CT

L P G de Farias, I G Padilha, M R L Lemos et al

Radiol Bras 2018, vol 51 (1)

http://www.scielo.br/scielo.php?pid=S0100-39842018000100063&script=sci_arttext&tlng=pt

 

■ Cryptococcosis in Colombia: compilation and analysis of data from laboratory-based surveillance

Patricia Escandón, Jairo Lizarazo, Clara Inés Agudelo, Elizabeth Castañeda

J Fungi (Basel) 2018 Mar; 4(1): 32

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872335/

 

■ Case report: a fatal case of cryptococcosis in an immunocompetent patient due to Cryptococcus deuterogatti (AFLP6/VGII)

  1. Bauer, C. Wickenhauser, A. Haak, N. Pazaitis, et al

JMM Case Rep. 2018 Oct; 5(10): e005168

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249430/

 

■ A call to arms: Quest for a cryptococcal vaccine

Marley C. Caballero Van Dyke, Floyd L. Wormley, Jr.

Trends Microbiol. 2018 May; 26(5): 436–446.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910246/

 

■ Epidemiology of cryptococcosis and cryptococcal meningitis in a large retrospective cohort of patients after solid organ transplantation

Ige A. George, Carlos A. Q. Santos, Margaret A. Olsen,

Open Forum Infect Dis. 2017 Winter; 4(1): ofx004

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414000/

 

■ Cryptococcosis in late stage multiple myeloma: conside

it

S J Bowcock, K Yip, K Majumder et al

British Journal of Haematology march 2017: 687-687

https://onlinelibrary.wiley.com/doi/full/10.1111/bjh.14496

 

■ Tuberculosis/cryptococcosis co-infection in China between 1065 an 2016

Wenjie Fang, Lei Zhang, Jia Liu, David W Denning et al

Emerg Microbes Infect. 2017 Aug; 6(8): e73

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583669/

 

■ Refractory and/or relapsing cryptococcosis associated with acquired imune deficiency syndrome: clinical features, genotype and virulence factors of cryptococcus spp. Isolates

Erika Nascimento, Lucia H. Vitali, Ludmilla Tonani et al

Am J Trop Med Hyg. 2016 May 4; 94(5): 975–981

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856629/

 

■ Cryptococcosis in acquired immunodeficiency syndrome patients clinically confirmed and/or diagnosed at necropsy in a teaching hospital in Brazil

Rafael Garcia Torres, Renata Margarida Etchebehere, Sheila Jorge Adad et al

Am J Trop Med Hyg. 2016 Oct 5; 95(4): 781–785

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062772/

 

■ Disseminated cryptococcosis with skin lesions: report of a case series

Marina Zoéga Hayashida, Camila Arai Seque, Victor Pavan Pasin et al

An Bras Dermatol. 2017 Sep-Oct; 92(5 Suppl 1): 69–72

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726682/

 

■ Immunity to Cryptococcus neoformans and C gatti during cryptococcosis

Josie F. Gibson, Simon A. Johnston

Fungal Genet Biol. 2015 May; 78: 76–86

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503824/

 

■ Integrated therapy for HIV and cryptococcosis

Sirawat Srichatrapimuk, Somnuek Sungkanuparph

AIDS Res Ther. 2016; 13: 42

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127046/

 

■ Criptococcosis

E K Maziarz, J R Perfect

Infec Dis Clin North Am 2016, vol30 (1): 179-206

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808417/

 

■ Cryptococcus spp. em excretas de Columba livia (pombos domésticos) provenientes de um hospital universitário no Sul do Brasil.

Lima, Cristiane Tavares de, Klafke, Gabriel Baracy and Xavier, Melissa Orzechowski

Arq. Inst. Biol., 2015, vol.82

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1808-16572015000100321&lng=en&nrm=iso

 

■ Fatal disseminated cryptococcosis with renal involvement in an HIV-infected patient

Daher, Elizabeth De Francesco et al

Rev. Inst. Med. trop. S. Paulo, Aug 2015, vol.57, no.4, p.365-367

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652015000400365&lng=en&nrm=iso&tlng=en

 

■ Cryptococcosis in Colombian children and literature review

Jairo Lizarazo, Patricia Escandón, Clara Inés Agudelo, Elizabeth Castañed

Mem Inst Oswaldo Cruz. 2014 Sep; 109(6): 797–804

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238773/

 

■ Cryptococcus gatti infections

Sharon C.-A. Chen, Wieland Meyer, Tania C. Sorrell

Clin Microbiol Rev. 2014 Oct; 27(4): 980–1024

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187630/

 

■ Approaches to antifungal therapies and their effectiveness among patients with cryptococcosis

Emily W. Bratton, Nada El Husseini, Cody A. Chastain et al

Antimicrob Agents Chemother. 2013 Jun; 57(6): 2485–2495

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716133/

 

■ Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the Infectious Diseases Society of American

John R. Perfect, William E. Dismukes, Francoise Dromer, et al

Clin Infect Dis. 2010 Feb 1; 50(3): 291–322

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826644/

 

■ Cutaneous cryptococcosis due to Cryptococcus gattii in a patient on chronic corticotherapy.

Bellissimo-Rodrigues, Fernando et al.

Rev. Soc. Bras. Med. Trop., Apr 2010, vol.43, no.2, p.211-212

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822010000200022&lng=en&nrm=iso

 

■ Ocorrência de Cryptococcus neoformans em excretas de pombos na cidade de Pelotas, Estado do Rio Grande do Sul.

Faria, Renata Osório de et al

Rev. Soc. Bras. Med. Trop., Abr 2010, vol.43, no.2, p.198-200

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822010000200018&lng=en&nrm=iso

 

■ Consenso em criptococose: 2008

Rev. Soc. Bras. Med. Trop., Out 2008, vol.41, no.5, p.524-544

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822008000500022&lng=en&nrm=iso

 

■ Suscetibilidade a antifúngicos de variedades de Cryptococcus neoformans isoladas de pacientes em hospital universitário.

Silva, Paulo Roberto da et al.

Rev. Soc. Bras. Med. Trop., Abr 2008, vol.41, no.2, p.158-16

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822008000200005&lng=en&nrm=iso

 

■ Paniculite criptocócica em transplantado renal.

Trope, Beatriz M. et al.

An. Bras. Dermatol., Jun 2008, vol.83, no.3, p.233-236

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962008000300007&lng=en&nrm=iso

 

■ Amaurose bilateral por menigoencefalite criptocócica: relato de caso

Aragão, Ricardo Evangelista Marrocos de et al.

Arq. Bras. Oftalmol., Fev 2008, vol.71, no.1, p.101-103

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492008000100021&lng=en&nrm=iso

 

■ Técnicas histopatológicas no diagnóstico de criptococose por Cryptococcus deficiente de cápsula: relato de caso.

Gazzoni, Alexandra Flávia, Pegas, Karla Lais and Severo, Luiz Carlos

Rev. Soc. Bras. Med. Trop., Fev 2008, vol.41, no.1, p.76-78

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822008000100015&lng=en&nrm=iso

 

■ Criptococose: estudo clínico-epidemiológico, laboratorial e das variedades do fungo em 96 pacientes.

Moreira, Tomaz de Aquino et al.

Rev. Soc. Bras. Med. Trop., Jun 2006, vol.39, no.3, p.255-258

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822006000300005&lng=en&nrm=iso

 

■  Dr Paulo Fernando Leite

Cardiologia/Prevenção Cardiovascular

Estratificação de Risco Cardiovascular

Novo endereço:

Consultório: Rua Padre Rolim 815/sala 601

Tel: 33245518 (Consulta Particular/Unimed)

– Centro Médico Unimed BH/Contagem/Pedro I

Belo Horizonte/MG/Brasil

CRMMG: 7026

Email: pfleite1873@gmail.com