Síndrome POEMS Online (POEMS Syndrome)

¨A síndrome de POEMS é uma entidade clínica única definida pela presença concomitante de doença monoclonal de plasmócitos, polineuropatia periférica e outras manifestações paraneoplásicas tais como organomegalias, endocrinopatias, alterações cutâneas, papiledema, lesões osteoescleróticas e sobrecarga de volume extravascular. Para o diagnóstico da doença não é necessária a presença de todas as manifestações relacionadas e o reconhecimento precoce desta patologia é importante para reduzir a morbidade. A síndrome de POEMS também é conhecida como mieloma osteoesclerótico, síndrome de Crow-Fukase e síndrome de Takatsuki. A causa da síndrome de Poems é desconhecida. Para o diagnóstico da doença não é necessária a presença de todas as manifestações relacionadas; por outro lado, nenhuma prova laboratorial pode ser considerada como patognomônica isoladamente. Após uma revisão sistemática das três maiores séries publicadas sobre a síndrome de Poemsreunindo um total de 226 pacientes, propuseram em 2003 a adoção de um sistema de critérios para o diagnóstico da síndrome de Poems baseado na freqüência e na relevância dos achados clínicos e laboratoriais que compõe esta patologia. O tratamento padrão da síndrome de POEMS ainda não está estabelecido e as principais opções são radioterapia, corticosteróides e agentes alquilantes, inclusive na forma de quimioterapia de altas doses com transplante autólogo de células-tronco hematopoiéticas.¨

■ An update on the diagnosis and management of the polyneuropathy of POEMS syndrome

Federica Cerri, Yuri Matteo Falzone, Nilo Riva, Angelo Quattrini

J Neurol. 2019; 266(1): 258–267

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343023/

■ POEMS syndrome: clinical update

Rachel Brown, Lionel Ginsberg

J Neurol. 2019; 266(1): 268–277

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342878/

■ Síndrome de POEMS incompleto asociado a enfermedad de Castleman multicéntrica y amiloidosis

González de la Aleja, P et al

Anales Sis San Navarra 2017, vol 40 (3)

http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1137-66272017000300475

■ POEMS syndrome and idiopathic portal hypertension: a possible association

Campos, Sara, Agostinho, Cláudia and Cipriano, Maria Augusta

Rev Esp Enferm Dig 2017, vol 109 (5): 393

http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082017000500026&lng=es&nrm=iso

■ Endocrine manifestations in POEMS syndrome: a case report and literature review

Hui Li, Yumeng Huang, Yan Li, Baozhong Zheng, Jingqiu Cui, Ming Liu

BMC Endocr Disord. 2019; 19: 33

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431048/

■ Positron emission tomography-computed tomography in a case of POEMS syndrome

Jose Rafael Infante, Lucía García, Juan Ignacio Rayo et al

Indian J Nucl Med. 2019 Jan-Mar; 34(1): 66–6

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352633/

■ Frequent central nervous system, pachymeningeal and plexus MRI changes in POEMS syndrome

Oliver J. Ziff, Chandrashekar Hoskote, Stephen Keddie et al

J Neurol. 2019; 266(5): 1067–1072

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469836

■ High-dose therapy and autologous stem cell transplantation in patients with POEMS syndrome: a retrospective study of the plasma cell disorder sub-committee of the chronic malignancy working party of the European Society for Blood & Marrow Transplantation

Gordon Cook, Simona Iacobelli, Anja van Biezen et al

Haematologica. 2017 Jan; 102(1): 160–16

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210246/

■ Raised VEGF: high sensitivity and specificity in the diagnosis of POEMS syndrome

Morgane Pihan, Stephen Keddie, Shirley D’Sa, Andrew J. Church, Kwee L. Yong, Mary M. Reilly, Michael P. Lunn

Neurol Neuroimmunol Neuroinflamm. 2018 Sep; 5(5): e486

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117193/

■ POEMS syndrome: an update

Andrea Nozza

Mediterr J Hematol Infect Dis. 2017; 9(1): e2017051

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584767/

■ Nerve pathologic features differentiate POEMS syndrome from CIDP

Ezequiel A. Piccione, Janean Engelstad, Peter J. Dyck et al

Acta Neuropathol Commun. 2016; 4: 11

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088652/

■ Pulmonary morbidity improves after autologous stem cell transplantation in POEMS syndrome

Satish Chandrashekaran, Angela Dispenzieri, Stephen S. Cha, Cassie C. Kennedy

Respir Med. 2015 Jan; 109(1): 122–130

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758677/

■ An occult malignancyt behing a demyelinatingj disease: POEMS syndrome

Saberio Lo Presti, Prashanth Kanagarajah, Daniela Pirela, Diana Morlote, Mike Cusnir

J Investig Med High Impact Case Rep. 2016 Oct-Dec; 4(4): 2324709616673389

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072185/

■ Longitudinal bioimpedance assessments to evaluate hydration in POEMS syndrome

Amara Callistus Nwosu, Lauren Morris, Catriona Mayland et al

BMJ Support Palliat Care. 2016 Sep; 6(3): 369–372

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013159/

■ POEMS syndrome: complex factors contributing to a delayed diagnosis

Rebecca Caroline Robey, Craig Campus, Beverly Ringuette, Mark Shumate

BMJ Case Rep. 2015; 2015: bcr2015213123

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680602/

■ Polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes (POEMS syndrome): a paraneoplastic syndrome

Sunil Kumar, Shruti Sharma

Oxf Med Case Reports. 2015 Mar; 2015(3): 237–240

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664845

■ POEMS syndrome, calciphylaxis and focal segmental glomerulosclerosis – VEGF as a possible link

Dorothee Heck, Miriam Mergen, Athina Ganner et al

BMC Neurol. 2014; 14: 210.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226878/

■ Outcomes of patients with POEMS syndrome treated initially with radiation

Michael S. Humeniuk, Morie A. Gertz, Martha Q. Lacy, et al

Blood. 2013 Jul 4; 122(1): 68–73

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067496/

■ POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, multiple myeloma and skin changes) with cranial vault plasmocytoma and the role of surgery in its management: a case report

Julio Plata Bello, Victor Garcia-Marin

J Med Case Rep. 2013; 7: 24

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016595/

■ Long-term therapy with lenalidomide in a patient with POEMS syndrome

Benjamin F. Chu, Arwa Shana’ah, Craig C. Hofmeister et al

Eur J Case Rep Intern Med. 2014; 1: 2014_000093

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326104/

■ Alcohol misuse link to POEMS syndrome in a patient

John Neary, Susan E. Goodwin, Lawrence B. Cohen, Manuela G. Neuman

Cancers (Basel) 2017 Oct; 9(10): 129

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664068/

■ How I treat POEMS syndrome